A retrospective study on clinical and demographic features of autoimmune vesiculobullous disorders from a rural tertiary care institute in Tamil Nadu

Rajalakshmi Ramalingam, Vikram Kumar Adaikalam Ganapathy, Seethalakshmi Rajanga Chandrasekar, Balasubramanian Narasiman, Deivam Subbaraya Gounder


Background: Autoimmune vesiculobullous disorders are a heterogenous group of skin diseases in which autoantibodies are directed against cell adhesion molecules which are essential for the integrity of skin and oral mucosa. They are clinically characterized by the presence of vesicles, bullae or erosions over the skin and/ or mucosa depending on the antibodies involved. They are divided into intraepidermal and subepidermal based on the location of the bulla. Among intraepidermal bullous disorders, pemphigus vulgaris (PV) is most common. Bullous pemphigoid (BP) is the most common among the subepidermal bullous disorders. Although they occur worldwide, the incidence shows geographical variation. A retrospective study was carried out with the objective to analyse the clinical and demographic profile of patients with autoimmune vesiculobullous disorders among patients attending a tertiary care teaching hospital in a rural setup.

Methods: A total of 137 case sheets were audited from the Medical Records Department of our institute. Details were collected and tabulated, compiled and analysed.

Results: Out of the 137 cases studied, intraepidermal autoimmune vesiculobullous disorders accounted for 63.4% of cases, and subepidermal autoimmune vesiculobullous disorders accounted for 36.6% of cases. Out of the 137 cases, 74 patients (54%) were females, and 63 patients (46%) were males. Majority of the patients were in the age group of 51-60 years (29.9%), followed by 41-50 years (24.1%) and 61-70 years (17.5%).

Conclusions: Pemphigus vulgaris was the most common among the intraepidermal autoimmune vesiculobullous disorders, and bullous pemphigoid was the most common among the subepidermal autoimmune vesiculobullous disorders.


Pemphigus vulgaris, Bullous pemphigoid intraepidermal, Subepidermal

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