DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20192136

Prevalence of metabolic syndrome in patients with psoriasis: a cross-sectional study in a tertiary care hospital of North India

Kamal Aggarwal, Shruti Sharma

Abstract


Background: Psoriasis is a chronic inflammatory disorder of skin, which has been recently linked to metabolic syndrome (MetS) by studies worldwide. Paucity of Indian data in this regard led us to conduct the present study, which aimed to identify the prevalence of metabolic syndrome (and its components) in patients with psoriasis and to determine its association with disease severity and duration.

Methods: This was a hospital-based cross-sectional study conducted over 50 clinically diagnosed patients of chronic plaque psoriasis and 50 age- and sex-matched control subjects. Metabolic syndrome was diagnosed by the South Asian Modified National Cholesterol Education Program Adult Treatment Panel III criteria (SAM-NCEP criteria). Data was analyzed using SPSS (version 17, SPSS Inc. Chicago, Illinois, USA). Descriptive statistics (mean, standard deviation, percentage), student’s t-test, and chi-square test were used.

Results: Metabolic syndrome was more prevalent in psoriasis patients than controls but the difference was not significant statistically (30% vs 16%, p=0.0979). Although psoriasis patients had higher prevalence of hypertrigly-ceridemia, hyperglycemia, hypertension and central obesity than controls, but the difference was statistically insignificant. The prevalence of low high-density lipoprotein (HDL) cholesterol was significantly higher in cases compared to controls (40% vs 18%, OR 3.0370, p=0.0159).

Conclusions: Metabolic syndrome and dyslipidemia are common in psoriasis patients, which signify the need for routine screening of metabolic syndrome in those patients.


Keywords


Psoriasis, Metabolic syndrome, Obesity, Hypertension, Dyslipidemia

Full Text:

PDF

References


Parisi R, Symmons DP, Griffiths CE, Ashcroft DM. Identification and management of psoriasis and associated comorbidity (IMPACT) project team. Global epidemiology of psoriasis: A systematic review of incidence and prevalence. J Invest Dermatol. 2013;133:377-85.

Ali NM, Kuruvila M, Unnikrishnan B. Psoriasis and metabolic syndrome: A case control study. Indian J Dermatol Venereol Leprol. 2014;80:255-7.

Lebwohl M. Psoriasis. Lancet. 2003;361:1197-204.

Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol. 2006;55:829–35.

Aurangabadkar SJ. Comorbidities in psoriasis. Indian J Dermatol Venereol Leprol. 2013;79:10-17.

Wilson PW, D’Agostino RB, Parise H, Sullivan L, Meigs JB. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation. 2005;112:3066-72.

Gelfand JM, Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006;296:1735-41.

Padhi T, Garima. Metabolic syndrome and skin: Psoriasis and beyond. Indian J Dermatol. 2013;58:299-305.

Azfar RS, Gelfand JM. Psoriasis and metabolic disease: Epidemiology and pathophysiology. Curr Opin Rheumatol. 2008;20:416-22.

Nisa N, Qazi MA. Prevalence of metabolic syndrome in patients with psoriasis. Indian J Dermatol Venereol Leprol. 2010;76:662-5.

Lakshmi S, Nath AK, Udayashankar C. Metabolic syndrome in patients with psoriasis. A comparative study. Indian Dermatol Online J. 2014;5:132-7.

Finlay AY. Current severe psoriasis and the rule of tens. Br J Dermatol. 2005;152:861-7.

Cohen AD, Bonneh DY, Reuveni M, Vardy DA, Naggan L, Halevy S. Drug exposure and psoriasis vulgaris: Case–control and case–crossover studies. Acta Derm Venereol. 2005;85:299–303.

Enas EA, Mohan V, Deepa M, Farooq S, Pazhoor S, Chennikkara H. The metabolic syndrome and dyslipidemia among Asian Indians: A population with high rates of diabetes and premature coronary artery disease. J Cardiometab Syndr. 2007;2:267-75.

Gisondi P, Tessari G, Conti A, Piaserico S, Schianchi S, Peserico A, et al. Prevalence of metabolic syndrome in patients with psoriasis: A hospital- based case- control study. Br J Dermatol. 2007;157:68-73.

Kim GW, Park HJ, Kim HS, Kim SH, Ko HC, Kim BS, et al. Analysis of cardiovascular risk factors and metabolic syndrome in Korean patients with psoriasis. Ann Dermatol. 2012;24:11‑5.

Zindanci I, Albayrak O, Kavala M, Kocaturk E, Can B, Sudogan S, et al. Prevalence of metabolic syndrome in patients with psoriasis. Sci World J. 2012;312463.

Salihbegovic EM, Hadzigrahic N, Cickusic AJ. Psoriasis and metabolic syndrome. Med Arch. 2015;69:85-7.

Girisha BS, Thomas N. Metabolic syndrome in psoriasis among urban South Indians: A case control study using SAM-NCEP criteria. J Clin Diagn Res. 2017;11:1-4.