DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20193240

Uniqueness of Dr. JRK’s 777 oil and how rancidity distorts Wrightia tinctoria

Aruna Vadivel, Amruthavalli Gatla Venkata, Soundharya Ravi, Gayathri Rajagopal

Abstract


Background: Several oil based AYUSH formulations are available for the treatment of psoriasis. In the recent time the importance given to Wrightia tinctoria has totally side-lined the quality of oil used in such preparation. Therefore, the importance of oil used in the formulation with reference to rancidity and how that would affect the therapeutic effect of Wrightia tinctoria needs to be studied.

Methods: In the present study we have adopted the following methods such as acid value, DPPH assay, nitric oxide inhibition, anti-glycation, CAM assay and fibroblast toxicity. The base oil used was studied for the above then the oil that showed least acid value was incorporated with Wrightia tinctoria extract and then studied by the above methods.

Results: The above study clearly show that the activity of Wrightia tinctoria decrease significantly when it was formulated in oil with high rancidity. Whereas the activity of Wrightia tinctoria was well preserved in oil with least rancidity. The contribution of acid value of oil in decreasing the activity of Wrightia tinctoria was much higher than the effect of acid value in increasing DPPH activity, Nitric oxide production, inducing glycation event and angiogenesis and causing fibroblast toxicity.

Conclusions: The present study clearly concludes that the acid value of base oil would not only worsen psoriasis but also can inactivate and convert the herbal metabolites to toxic elements. Due diligence is necessary in preparing AYUSH drugs where not only the quality of herbs should be considered but also the oil base as well. 


Keywords


Rancid oil, Wrightia tinctoria, 777 oil, Anti-oxidant, Coconut oil

Full Text:

PDF

References


Smith CH. Psoriasis and its management. BMJ. 2006;333(7564):380–4.

Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007;370(9583):263–71.

Ashcroft DM, Li Wan PA, Williams HC, Griffiths CEM. Systematic review of comparative efficacy and tolerability of calcipotriol in treating chronic plaque psoriasis. BMJ. 2000;320:963-7.

Griffiths CE, Clark CM, Chalmers RJ, Li Wan Po A, Williams HC. A systematic review of treatments for severe psoriasis. Health Technol Assess. 2000;4:1-125.

Whan B. Kim, MD. Diagnosis and management of psoriasis. Can Fam Physician. 2017;63(4):278–85.

El-Gammal A, Di Nardo V, Daaboul F, Tchernev G, Wollina U, Lotti J, et al. Is There a Place for Local Natural Treatment of Psoriasis? Open Access Maced J Med Sci. 2018;6(5):839–42.

Wahedi HM, Jeong M, Chae JK, Do SG, Yoon H, Kim SY. Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. Phytomedicine. 2017;28:19–26.

Srivastava R. A review on phytochemical, pharmacological, and pharmacognostical profile of Wrightia tinctoria: Adulterant of kurchi. Pharmacogn Rev. 2014;8(15):36–44.

Sundarrajan S, Lulu S, Arumugam M. Deciphering the Mechanism of Action of Wrightia tinctoria for Psoriasis Based on Systems Pharmacology Approach. J Alternative Complementary Med. 2017;23(11):1-13.

Aruna V, Amruthavalli Gv, Gayathri R. Use of cosmetic products for treating certain diseases- Know the science. J Cosmetic Dermatol. 2018;1-5.

Ullah HMA, Zaman S, Juhara F, Akter L, Tareq SM, Masum EH, et al. Evaluation of antinociceptive, in-vivo & in-vitro anti-inflammatory activity of ethanolic extract of Curcuma zedoaria rhizome. BMC Complement Altern Med. 2014;14:346.

Gunapadam Part 2 Thathu-Jeeva Vagupu. Indian Medicine, Homeopathic Dept., 2004: 65–66.

Aruna V, Rajagopal G. Rancid Oil- The Hidden Villain of Psoriasis. Res Rev: A J Unani, Siddha Homeopathy. 2015;2(2):22–5.

Aruna V, Rajagopal G, Abbas A. Evidence for the Superior Quality and Efficacy of Dr. JRK’s 777 Oil. Res Rev: A J Drug Design Discovery. 2017: 19-21.

Aruna V, Rajagopal G. Secret behind the Safety of the Siddha Products: An Insight from Metal Chelation. Res Rev: A J Unani, Siddha Homeopathy. 2016;3(2):24–7.