Acute methotrexate toxicity in psoriasis

Authors

  • Peram Karunakar Department of Dermatology, Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Guntur, Andhra Pradesh, India
  • Venkateswara Rao Garimella Department of Dermatology, Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Guntur, Andhra Pradesh, India
  • Chinmai Yerram Department of Dermatology, Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Guntur, Andhra Pradesh, India
  • Anusha Gogula Department of Dermatology, Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Guntur, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20193245

Keywords:

Methotrexate, Psoriasis, Toxicity

Abstract

We describe two cases of low dose methotrexate (MTX) toxicity in patients with psoriasis. Patient was a 49-year-old male, known case of chronic plaque psoriasis from 10 years on and off. He was advised to take MTX 2.5 mg 2 days a week but patient took 2.5 mg twice daily (BD) for 6 continuous days following which he developed ulceration over psoriatic plaques and bone marrow suppression. MTX is safe and effective if adhered to standard treatment guidelines but inadverent use may lead to it’s toxicity.

Author Biographies

Peram Karunakar, Department of Dermatology, Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Guntur, Andhra Pradesh, India

PG in Department of DVL

Venkateswara Rao Garimella, Department of Dermatology, Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Guntur, Andhra Pradesh, India

Professor and HOD, Department of DVL

Chinmai Yerram, Department of Dermatology, Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Guntur, Andhra Pradesh, India

PG in Department of DVL

Anusha Gogula, Department of Dermatology, Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Guntur, Andhra Pradesh, India

PG in Department of DVL

References

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Published

2019-07-24