A study of vitiligo with other coexisting diseases in DVL department of a teaching hospital
Keywords:Vitiligo, Coexisting diseases, Leukotrichia
Background: Vitiligo is characterized by milky-white macules affecting the skin and mucous membranes. It occurs due to the progressive loss of functioning melanocytes from the affected areas. It may affect any age group and gender. Genetic, immunological, neural, and self-destructive mechanisms may be involved in its pathogenesis. Both autoimmune and non-autoimmune disorders have been reported to be associated with vitiligo.
Methods: This is a descriptive study conducted in the Department of DVL of a teaching hospital from August 2020 to November 2021. 50 vitiligo patients were enrolled in the study. Relevant data was recorded using the customized case proforma and analyzed.
Results: Majority of the patients belonged to the age group of 21-30 years (28%). Males (54%) outnumbered females. The mean duration of the disease was 51.6 months. The familial incidence of vitiligo was 18%. Majority of the cases were of vitiligo vulgaris type (50%). Koebnerization was seen in 20% and leukotrichia in 34% of the cases. 14% of cases had other coexisting cutaneous diseases. Urticaria (4%) was the most common followed by alopecia areata, acne, atopic dermatitis and psoriasis. 44% of the study population had systemic comorbidities. Iron deficiency anemia was the most common seen in 20% of cases followed by hypothyroidism, diabetes mellitus, dyslipidemia and hypertension.
Conclusions: A detailed history, comprehensive cutaneous and systemic examination, relevant laboratory workup is mandatory in a newly diagnosed patient with vitiligo. A regular follow-up and psychiatric evaluation is also necessary to reduce the disease burden.
Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: A comprehensive overview. Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011;65(3):473-91.
Anstey AV. Disorders of Skin colour. In: Burns T, Breathnach S, Cox N and Griffiths C, editors. Rook’s Textbook of Dermatology. 8th ed. Oxford: Blackwell Publishing. 2010;58.46-9.
Amer AA, Gao XH. Quality of life in patients with vitiligo: an analysis of the dermatology life quality index outcome over the past two decades. Int J Dermatol. 2016;55:608-14.
Pajvani U, Ahmad N, Wiley A, Levy RM, Kundu R, Mancini AJ, et al. The relationship between family medical history and childhood vitiligo. J Am Acad Dermatol. 2006;55:238-44.
Ezzedine K, Lim HW, Suzuki T, Katayama I, Hamzavi I, Lan CC, et al. Vitiligo Global Issue Consensus Conference Panelists. Pigment Cell Melanoma Res. 2012;25:E1-13.
Poojary SA. Vitiligo and associated autoimmune disorders: A retrospective hospital-based study in Mumbai, India. Allergol Immunopathol (Madr). 2011;39:356-61.
Sehgal VN, Srivastava G. Vitiligo: Compendium of clinico-epidemiological features. Indian J Dermatol Venereol Leprol. 2007;73:149-56.
Pandve HT. Vitiligo: is it just a dermatological disorder? Indian J Dermatol. 2008;53:40-1.
Das AK, Chowdhury AK, Sinha AK. An immunological study of vitiligo. Indian J Dermatol Venereol Leprol. 1997;63(2):91-4.
Arushi D, Ashish D, Maruti K. Systemic and cutaneous associations of vitiligo. MGM Journal of Medical Sciences. 2020;7:22.
Vora RV, Patel BB, Chaudhary AH, Mehta MJ, Pilani AP. A Clinical Study of Vitiligo in a Rural Set up of Gujarat. Indian J Community Med. 2014;39(3):143-6.
Shankar DS, Shashikala K, Madala R. Clinical patterns of vitiligo and its associated co morbidities: A prospective controlled cross-sectional study in South India. Indian Dermatol Online J. 2012;3(2):114-8.
Gopal KV, Rama Rao GR, Kumar YH, Appa Rao MV, Vasudev P. Vitiligo: a part of a systemic autoimmune process. Indian J Dermatol Venereol Leprol. 2007;73:162-5.
Shah H, Mehta A, Astik B. Clinical and sociodemographic study of vitiligo. Indian J Dermatol Venereol Leprol. 2008;74:701.
Mahajan VK, Vashist S, Chauhan PS, Mehta KIS, Sharma V, Sharma A. Clinico-Epidemiological Profile of Patients with Vitiligo: A Retrospective Study from a Tertiary Care Center of North India. Indian Dermatol Online J. 2019;10(1):38-44.
Altaf H, Shah IH, Ahmad QM. Evaluation of thyroid function and presence of antithyroid peroxidase antibodies in patients with vitiligo. Egyptian Dermatol Online J. 2010;6(1):1-12.
Shajil EM, Agrawal D, Vagadia K, Marfatia YS, Begum R. Vitiligo: Clinical profiles in Vadodara, Gujarat. Indian J Dermatol. 2006;51:100-4.
Behl PN, Kotia A, Sawal P. Vitiligo: Age-group related trigger factors and morphological variants. Indian J Dermatol Venereol Leprol. 1994;60:275-9.
Alzolibani A. Genetic epidemiology and heritability of vitiligo in the Qassim region of Saudi Arabia. Acta Dermatoven APA. 2009;18(3):119-25.
Al-Mutairi N, Al-Sebeih KH. Late onset vitiligo and audiological abnormalities: Is there any association? Indian J Dermatol Venereol Leprol. 2011;77:571-6.
Aydin AF, Aydıngöz İE, Doğru-Abbasoğlu S, Vural P, Uysal M. Association of Leukotrichia in Vitiligo and Asp148Glu Polymorphism of Apurinic/ Apyrimidinic Endonuclease 1. Int J Trichol. 2017;9(4):171-6.
Swati G, Vikram M, Karaninders M, Pushpinder C, Mrinal G, Yadav RS et al. Vitiligo and associated disorders including autoimmune diseases: A prospective study of 200 Indian patients. Pigment International. 2015;2:91.
Koranne RV, Sehpgal VN, Sachdeva KG. Clinical Profile of Vitiligo in North India. Indian J Dermatol Venereol Leprol. 1986;52(2):81-2.
Martis J, Bhat R, Nandakishore B, Shetty JN. A clinical study of vitiligo. Indian J Dermatol Venereol Leprol. 2002;68(2):92-3.
Fatani MI, Al Sharif SH, Alfif KA, Khan AS, Hussain WA, Banjar AA. The clinical patterns of vitiligo “hospital-based study” in Makkah region, Saudi Arabia. J Dermatol Dermatol Surg. 2014;18:17-21.