Randomised controlled study for comparing the efficacy of tretinoin 0.05% cream alone versus tretinoin combined with microdermabrasion in adult patients of alopecia areata

Authors

  • Navneet Kaur Department of Dermatology, Venerology and Leprosy, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
  • Ankita . Department of Dermatology, Venerology and Leprosy, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
  • Kriti Maheshwari Department of Dermatology, Venerology and Leprosy, Government Institute of Medical Science, Greater Noida, Uttar Pradesh, India
  • Gaurav Menghani Department of Dermatology, Venerology and Leprosy, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
  • Kapil Vyas Department of Dermatology, Venerology and Leprosy, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
  • Kalpana Gupta Department of Dermatology, Venerology and Leprosy, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
  • M. K. Singh Department of Dermatology, Venerology and Leprosy, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20220492

Keywords:

Alopecia areata, Tretinoin, MDA

Abstract

Background:  Alopecia areata is non-scarring autoimmune disease. It is characterized by discrete patches of non-scarring hair loss and may involve scalp, eyebrows, eyelashes, beard, axillary hair and pubic hair. Therapeutic armamentarium is expanding with detailed elucidation of patho-mechanisms and emergence of new drugs like janus kinase inhibitors.

Methods: An interventional prospective study was conducted on the patients which were randomized into two groups (19 patients each) by lottery system, patients of group A were treated with tretinoin 0.05% cream whereas in group B patients microdermabrasion (MDA) was performed at baseline, 3rd, 6th, 9th and 12th weeks in addition to the application of tretinoin 0.05% cream daily.

Results: The mean GPI% in Group A was 6.26±5.13 and group B was 32.63±15.29% which is significantly higher at the end of 2 weeks (p=0.001). At 8 weeks, mean GPI in group A was 10.95±6.79 and in group B was 51.42±12.42 which was also significantly higher (p=0.026) as compared to group A. Similarly mean VAS in group A at 2 weeks and 8 weeks (0.62±0.51 and 1.1±0.67) and in group B was (3.27±1.53 and 5.16±1.26) which was significantly higher with difference in p value at 2 weeks between the two groups was p=0.001 and at 8 weeks was p=0.017. There was significant change in GPI and VAS at 8 weeks, in group A as compared to group B.

Conclusions: This study revealed that tretinoin was more effective than the combination with MDA.

Author Biography

Navneet Kaur, Department of Dermatology, Venerology and Leprosy, Dayanand Medical College and Hospital, Ludhiana, Punjab, India

 PROFESSOR and HEAD OF DEPARTMENT

SKIN,VD & LEPROSY

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Published

2022-02-24

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Original Research Articles