A comparative study of fractional carbon dioxide laser, narrowband ultraviolet B and topical tacrolimus 0.1% ointment versus narrowband ultraviolet B, topical tacrolimus 0.1% ointment in stable vitiligo


  • Anusha Putta Department of DVL, M. R. Medical College, Kalaburagi, Karnataka, India
  • Mohammed Waseem Javed Department of DVL, KBNIMS, Kalaburagi, Karnataka, India




Fractional CO2 laser, NBUVB, Tacrolimus, Vitiligo


Background: Vitiligo, an acquired pigmentary disorder of skin and mucous membrane characterized by well circumscribed depigmented macules that occur secondary to selective destruction of melanocytes. Fractional CO2 laser system is a recent advancement in the treatment of vitiligo which works on the concept of fractional photo-thermolysis, in which microscopic treatment zones are created which help in increasing the penetration of topically applied agent which indirectly improves drug efficacy.

Methods: A comparative study was conducted on 40 patients of stable vitiligo attending OPD, Dept of DVL with fractional CO2 laser, narrowband ultraviolet B (NBUVB) and topical tacrolimus 0.1% vs NBUVB, topical tacrolimus 0.1% for a duration of 4 months and patients were followed up for 12 weeks post treatment.

Results: Patients on Fractional CO2 laser in combination with NBUVB and topical tacrolimus 0.1% ointment showed >50% improvement compared with other group, with duration for initiation of pigmentation being comparatively less.

Conclusions: The treatment protocol with CO2 laser in combination with topical tacrolimus 0.1% cream and NBUVB for stable vitiligo was more effective than NBUVB and topical tacrolimus 0.1% alone and this study demonstrates that adding fractional CO2 laser improves repigmentation rate of vitiliginous lesions.

Author Biographies

Anusha Putta, Department of DVL, M. R. Medical College, Kalaburagi, Karnataka, India

Department Of DVL

Post graduation

Mohammed Waseem Javed, Department of DVL, KBNIMS, Kalaburagi, Karnataka, India

Dept of DVL

Senior Resident


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