A clinic epidemiological study of cutaneous markers of internal malignancy

Authors

  • Jyothi Sri Teki Department of Civil Surgery, ESI Dispensary, Devapuram, Guntur, Andhra Pradesh, India
  • Satya Sri Teki Department of DVL, Gandhi Medical College, Secunderabad, Telangana, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20202649

Keywords:

Cutaneous markers, Internal malignancy, Carcinoma cervix, Pruritus

Abstract

Background: The skin provides important clues to many systemic diseases. Changes in the skin can be a marker for internal malignancies. If any cutaneous disorder associated with malignancy can be recognized early, it paves way to rapid diagnosis and treatment of the underlying malignancy. we made such an attempt to recognize cutaneous disorders in 40 patients suffering with internal malignancies at government general hospital, Guntur attending dermatology and radiology departments.

Methods: Patients with internal malignancy having specific features were included in our study. Biopsy was done in every patient. The present study lasted for 21 months i.e., from January 2008 to September 2009.

Results: We found that carcinoma cervix was the most common malignancy in females and bronchogenic carcinoma in males associated with cutaneous markers. The markers observed were pruritus, acquired lymphorroids, para neoplastic pemphigus, acquired icthyosis and disseminated granuloma annulare. Cutaneous markers were observed within 6 months from onset of internal malignancies.

Conclusions: Recognition of any para-neoplastic skin disorders should raise suspicion for an internal malignancy which helps in rapid diagnosis and treatment of underlying malignancy.

References

Becker SW, Kahn D, Rothman S. Cutaneous manifestations of internal malignant tumours. Arch Dermatol Syphilol. 1942;45:1069-80.

Curth HO, Aschner BM. Genetic studies on acanthosis nigricans. Arch Dermatol. 1959;79:55.

Sneddon IB. Acquired icthyosis and related conditions. Int J Dermatology. 1984:23(7):458-61.

Niimi Y, Kawana S, Hashimato T. Paraneoplastic Pemphigus Associated With Uterine Carcinoma. J Am Acad Dermatol. 2003;48(5):69-72.

Li A, Hogan DJ, Sansui DI, Smoller BR. Granuloma Annulare and malignant neoplasms. Am J Dermatopath. 2003;25:113-6.

Worth WDL, Carlne V, Susser WS. Dermatologic diseases of the breast and nipple. J Am Acad Dermatol. 2000:43(5):735-51.

Yeh JS, Munn SE, Plunkett TA. Coexistence of acanthosis nigricans and the sign of lesar-trelat in a patient of adenocarcinoma: a case report and literature review. J Am Acad Dermatology. 2000:42:357-62.

Kramer KH, Lee MM, Scotto J. Xeroderma pigmentosum. Cutaneous, ocular and neurologic abnormalities in 830 published cases. Arch Dermatol. 1987;123(2):241-50.

Kramer KH, Lee MM Andrews AD. the role of sunlight and DNA repair in melanoma and non-melanoma skin cancer. The xeroderma pigmentosum paradigm. Arch Dermatol. 1994;130(8)1018-21.

Soubrier MJ, Jacques JD, Sauvezie BJM. POEMS Syndrome: a study of 25 cases and review of literature. Am J Med. 1994:97:543-53.

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Published

2020-06-23

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Section

Original Research Articles