DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20195575

A study of clinical course and therapeutic response of sexually transmitted infections in people living with HIV/AIDS

Ram Kanta Halder, Pradeep Balasubramanian

Abstract


Background: Human immunodeficiency virus (HIV) continues to be a major public health problem worldwide. Once a person is infected with HIV, the manifestations of other infections and diseases are altered due to waning of the host immunity.

Methods: This study was carried out in HIV reactive patients in Command Hospital, Pune. The types of sexually transmitted infections (STIs) in those patients and the response to therapy were studied in detail. The statistical data was expressed as number and percentages.

Results: In this study, 52 people living with HIV/AIDS (PLWHA) who were having various STIs were included. Majority of the patients in this study belonged to the age group of 20-34 years (75%). The most common STIs encountered were condyloma acuminata (38.45%) followed by syphilis (30.77%), lymphogranuloma venereum, herpes genitalis, chancroid, molluscum contagiosum, gonorrhea and granuloma inguinale. Resistance to antimicrobial therapy at the standard dosage, requirement of higher dosage, resistance and relapse of infections were observed in the patients with PLWH.

Conclusions: Several STIs coexisted with HIV infected patients. Unusual clinical presentations, clinical course and treatment failure in STI were common in HIV infected individuals. Hence all STI patients should be screened for HIV and vice-versa.


Keywords


Sexually transmitted infections, HIV, Coexistence

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References


Write RG, Orroth KK, Glynn JR, Freeman EE, Bakker R, Habbema JD, et al. Treating curable sexually transmitted infections to prevent HIV in Africa: still an effective control strategy? J Acquir Immune Defic Syndr. 2008;47(3):346-53.

Hayes RJ, Jones DW, Celum C, Wijgert JV, Wasserheit J. Treatment of sexually transmitted infections for HIV prevention: End of the road or new beginning? AIDS. 2010;24(04).

Holmes KK, Levine R, Weaver M. Effectiveness of condoms in preventing sexuall transmitted infections. Bulletin World Health Organization. 2004;82:454-61.

Hutchinson CM, Hook EW, Shepherd M. Altered clinical presentation of early syphilis in patients with HIV infection. Ann Intern Med. 1994;121:94-9.

Zetola NM, Klausner JD. Syphilis and HIV infection: an update. Clin Infect Dis. 2007;44:1222-8.

Koranne RV, Raju PJ. Atypical manifestations of early syphilis. Indian J Dermato Venereol Leprol. 1990;56:37-9.

Lawrence D, Cresswell F, Whetham J, Fisher M. Syphilis treatment in the presence of HIV: the debate goes on. Curr Opin Infect Dis. 2015;28:44-52.

Stewart JA, Reef SE, Pellet PE, Corey L, Whitley RJ. Herpesvirus infections in persons infected with human immunodeficiency virus. Clin Infect Dis. 1995;21:1114-20.

Collis TK, Celum CL. The clinical manifestations and treatment of sexually transmitted diseases in human immunodeficiency virus-positive men. Clin Infect Dis. 2001;32(4):611-22.

von Krog G, Wikstron A, Syrjanen S. Anal and penile condylomas in HIV-negative and HIV-positive men: Clinical, histological and virological characteristics correlated to therapeutic outcome. Acta Derm Venereol. 1995;75:470-4.