A prospective observational study of follicular unit excision grafting for the management of stable vitiligo

Authors

  • Raj Kumar Department of DVL, BRD Medical College, Gorakhpur, Uttar Pradesh, India
  • Sunil Kumar Prajapati Department of DVL, BRD Medical College, Gorakhpur, Uttar Pradesh, India
  • Santosh Kumar Singh Department of DVL, BRD Medical College, Gorakhpur, Uttar Pradesh, India
  • Anil Kumar Gupta Department of DVL, BRD Medical College, Gorakhpur, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20194568

Keywords:

Vitiligo, Leukotrichia, Follicular unit extraction grafting

Abstract

Background: Vitiligo is a common acquired idiopathic and often, familial hypomelanosis, which is characterized by pale white macules that enlarges centrifugally over time. In India, vitiligo is associated with marked social stigma, thus demanding its effective management. Stable vitiligo lesions known to be relatively refractory medical therapy require surgical therapies like skin grafting or grafting of invitro cultured and non-cultured melanocytes or follicular unit excision (FUE) grafting.

Methods: A prospective observational study was done on patients of stable vitiligo. A total of 20 patients were enrolled and underwent FUE grafting for study of effectiveness and complication.

Results: A total of 20 patients of stable vitiligo were studied with or without leukotrichia in which good to excellent response was seen in 13 (65%), fair in 6 (30%) and poor in 1 (5%) patients.

Conclusions: FUE is a superior and upcoming methodology which is cost effective, reliable, less disfiguring, very low morbidity and results in good color match in patients with stable vitiligo.

Author Biography

Sunil Kumar Prajapati, Department of DVL, BRD Medical College, Gorakhpur, Uttar Pradesh, India

Department of DVL

Junior Resident

References

Handa S, Kaur I. Vitiligo: Clinical findings in 1436 patients. J Dermatol. 1999;26:653-7.

Valia AK, Dutta PK. IADVL Text book and Atlas of Dermatology. Bhalani Publishing House: New York; 1996: 500-586.

Taïeb A, Picardo MN. Review Clinical practice. Vitiligo. Engl J Med. 2009;360(2):160-9.

Staricco RG. Amelanotic melanocytes in the outer sheath of the human hair follicle. J Invest Dermatol. 1959;33:295-7.

Ortonne JP, MacDonald DM, Micoud A, Thivolet J. PUVA-induced repigmentation of vitiligo: A histochemical (split-DOPA) and ultrastructural study. Br J Dermatol. 1979;101:1-12.

Cui J, Shen LY, Wang GC. Role of hair follicles in the repigmentation of vitiligo. J Invest Dermatol. 1991;97:410-6.

Arrunátegui A, Arroyo C, Garcia L, Covelli C, Escobar C, Carrascal E, et al. Melanocyte reservoir in vitiligo. Int J Dermatol. 1994;33:484-7.

Grichnik JM, Ali WN, Burch JA, Byers JD, Garcia CA, Clark RE, et al. KIT expression reveals a population of precursor melanocytes in human skin. J Invest Dermatol. 1996;106:967-71.

Na GY, Seo SK, Choi SK. Single hair grafting for the treatment of vitiligo. J Am Acad Dermatol. 1998;38:580-4.

Vanscheidt W, Hunziker T. Repigmentation by outer-root-sheath-derived melanocytes: Proof of concept in vitiligo and leucoderma. Dermatology. 2009;218:342-3.

Kumaresan M. Single-hair follicular unit transplant for stable vitiligo. J Cutan Aesthet Surg. 2011;4:41-3.

Sacchidanand S, Thakur P, Purohit V, Sujaya SN. Follicular unit extraction as a therapeutic option for Vitiligo. J Cutan Aesthet Surg. 2013;6:229-31.

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Published

2019-10-21

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Section

Original Research Articles