Evaluation of vitamin D status, selenium and C-reactive protein level in psoriasis


  • S. Sumathi Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Pillaiyarkuppam, Puducherry, India
  • S. Vinod Babu Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Pillaiyarkuppam, Puducherry, India
  • K. Karthikeyan Department of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Puducherry, India




C-reactive protein, Vitamin-D, Psoriasis, Selenium


Background: Psoriasis is an inflammatory skin disease associated with a variety of clinical conditions. Study aim to evaluate the association of vitamin D, selenium and C-reactive protein (CRP) levels in psoriasis.

Methods: This hospital-based case-control study involved 50 psoriasis cases and 47 healthy individuals. Serum vitamin D, selenium and CRP levels were measured, and the general demographic values were also recorded.

Results: Statistical analysis revealed that vitamin D levels are significantly lower in psoriasis (p<0.005). Among the demographic parameters, obesity was found more common among psoriasis cases than controls. Serum selenium and CRP levels were not significantly different between the two groups.

Conclusions: Vitamin D deficiency is strongly associated with psoriasis. Vitamin D supplementation can be useful in psoriasis management and also in the reduction of obesity. Serum selenium and CRP levels aren’t significant markers to demonstrate psoriasis.


Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1, 25-dihydroxyvitamin D3, and the immune system. American J Clini Nutr. 2004;80(6):1717S-20S.

Dombrowski Y, Peric M, Koglin S, Kammerbauer C, Göß C, Anz D, et al. Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Sci Trans Med. 2011;3(82):38.

Gisondi P, Rossini M, Di Cesare A, Idolazzi L. Vitamin D status in patients with chronic plaque psoriasis. Br J Dermatol. 2012;166(3):505-10.

Fu LW, Vender R. Systemic role for vitamin d in the treatment of psoriasis and metabolic syndrome. Dermatol Res Pract. 2011: 1-4.

Peric M, Koglin S, Dombrowski Y, Groß K, Bradac E, Büchau A, et al. Vitamin D analogs differentially control antimicrobial peptide/“alarmin” expression in psoriasis. PloS One. 2009;4(7):e6340.

Fu LW, Vender R. Review. Systemic role for vitamin D in the treatment of psoriasis and metabolic syndrome. Derm Res Persp. 2011;2011:ID 276079.

Nisa N, Qazi MA. Prevalence of metabolic syndrome in patients with psoriasis. Ind J Dermatol Venereol Leprol. 2010;76:662-5.

Serwin AB, Wasowicz W, Gromadzinska J, ożena Chodynicka B. Selenium status in psoriasis and its relations to the duration and severity of the disease. Nutr. 2003;19(4):301-4.

Matloob NA. Selenium Level in Lichen Planus and in Psoriasis and Its Relation to Chronicity and Severity of Both Diseases. Iraq J Med Sci. 2011;9(1):11-7.

Jain VK, Lal H. C-reactive protein and uric acid levels in patients with psoriasis. Ind J Clini Biochem. 2011;26(3):309-11.

Donadini A, Fiora C, Regazzini R, Perini D, Minoia C. Selenium plasma levels in psoriasis. Clini Experiment Dermatol. 1992;17(3):214-6.

Naziroglu M, Yildik K, Tamturk B, Erturan I, Flores-Arce M. Selenium and psoriasis. Biol Trace Elem Res. 2012;150(1-3):3-9.

Lowe KE, Norman AW. Vitamin D and psoriasis. Nutrition Rev. 1992;50(5):138-42.

Zuchi MF, Azevedo PD, Tanaka AA, Schmitt JV, Martins LE. Serum levels of 25-hydroxy vitamin D in psoriatic patients. Anais Brasileiros Dermatol. 2015;90(3):430-2.

Marques CD, Dantas AT, Fragoso TS, Duarte ÂL. The importance of vitamin D levels in autoimmune diseases. Revista Brasileira Reumatol. 2010;50(1):67-80.

Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clini Nutr. 2000;72(3):690-3.

Vanlint S. Vitamin D and obesity. Nutr. 2013;5(3):949-56.

Armstrong AW, Harskamp CT, Armstrong EJ. The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies. Nutr Diab. 2012;2(12):e54.

Al-Jebori AA. Serum Selenium in Psoriatic Patients. Iraqi J Commu Med. 2007;20(3):409-13.

Serwin AB, Chodynicka B, Wasowicz W, Gromadzińska J. Selenium nutritional status and the course of psoriasis. Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego. 1999;6(35):263-5.

Vadakayil AR, Dandekeri S, Kambil SM, Ali NM. Role of C-reactive protein as a marker of disease severity and cardiovascular risk in patients with psoriasis. Ind Dermatol Online J. 2015;6(5):322-5.

Farshchian M, Ansar A, Sobhan M, Hoseinpoor V. C-reactive protein serum level in patients with psoriasis before and after treatment with narrow-band ultraviolet B. Anais Brasileiros Dermatologia. 2016;91(5):580-3.

Strober B, Teller C, Yamauchi P, Miller JL, Hooper M, Yang YC, et al. Effects of etanercept on C‐reactive protein levels in psoriasis and psoriatic arthritis. Brit J Dermatol. 2008;159(2):322-30.

Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, et al. C‐reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy. J Euro Acad Dermatol Venereol. 2010;24(7):789-96






Original Research Articles