Case report of primary cutaneous anaplastic large cell lymphoma of adult female patient visiting dermatology clinic of King Abdul-Aziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia, 2018


  • Hani Saad Al-Mugti Department of Dermatology, King Fahad General Hospital, Jeddah, Saudi Arabia
  • Ola Yaseen Samman Department of Primary Health Care / Community and Preventive Medicine, King Abdullah International Medical Research Centre, King Saud bin Abdul-Aziz University for Health Science, Western Region, Jeddah, Saudi Arabia



Primary cutaneous anaplastic large cell lymphoma, Pyoderma gangrenosum, Lymphoma, Thigh


Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare T-cell cutaneous lymphoma consisting of CD30 positive typically anaplastic-appearing cells. PCALCL had been distinguished from systemic anaplastic large cell lymphoma (ALCL) and lymphomatous papulosis by World Health Organization classification of lymphoid neoplasms. Previous studies have shown PCALCL has an excellent overall survival with few patients dying from disease. This is a case report study design with detailed history, examination of 54-years-old female patient with a painful nodular lesion in the left thigh, which is misdiagnosed as Pyoderma Gangrenosum.


Sauder MB, O'Malley JT, LeBoeuf NR. CD30+ lymphoproliferative disorders of the skin. Hematology/Oncology Clinics. 2017;31(2):317-34.

Willemze R. Cutaneous T-cell lymphoma. Dermatology. Spain: Mosby. 2008: 1867-1886.

Williams HC, Wang HH, Kadin ME. Epidemiology of lymphomatoid papulosis. Cancer. 1993;72(1):297-8.

Bains A, Vedant D, Shanker V, Tegta GR. Primary cutaneous anaplastic large cell lymphoma masquerading as large pyogenic granuloma. Indian Dermatology Online J. 2016;7(6):526.

The portal for rare diseases and orphan drugs: Primary cutaneous anaplastic large cell lymphoma, 2018. Available at cgi-bin/OC_Exp.php?Lng=GB&Expert=300865; Accessed on 8 March 2019.

Sen S, Gangopadhyay A, Chatterjee U, Ray A. Primary cutaneous CD30+ anaplastic lymphoma: a case report and reappraisal. Indian J Dermatol. 2013;58(2):165.

Asha LK, Thomas D, Binitha MP, Nandakumar G. Primary cutaneous multifocal CD 30+ anaplastic large cell lymphoma. Indian J Dermatol Venereol Leprol. 2006;72(5):376.

Krishnan J, Tomaszewski MM, Kao GF. Primary cutaneous CD30‐positive anaplastic large cell lymphoma. Report of 27 cases. Journal of cutaneous pathology. 1993;20(3):193-202.

Kumaran MS, Jithendriya M, Nagaraj P, Tirumalae R, Jayaseelan E. Anaplastic lymphoma kinase-positive primary cutaneous anaplastic large cell lymphoma-Is it a new variant?. Indian J Dermatol Venereol Leprol. 2012;78(3):354.

Campo E, Chott A, Kinney MC, Leoncini L, Meijer CJ, Papadimitriou CS, Piris MA, Stein H, Swerdlow SH. Update on extranodal lymphomas. Conclusions of the Workshop held by the EAHP and the SH in Thessaloniki, Greece. Histopathology. 2006;48(5):481-504.

Tchernev G, Cardoso JC, Arseniev L, Okamoto H. Extrinsic apoptotic pathways: a new potential" target" for more sufficient therapy in a case of cutaneous anaplastic large cd30+ alk-T-cell lymphoma. Indian J Dermatol. 2011;56(1):87-91.