Scar sarcoidosis: additional involvement of de novo sites and update on immunopathogenesis

Authors

  • Vasudha A. Belgaumkar Department of Skin and VD, B. J. Govt. Medical College and Hospital, Pune, Maharashtra, India
  • Ravindranath B. Chavan Department of Skin and VD, B. J. Govt. Medical College and Hospital, Pune, Maharashtra, India
  • Prernaa R. Suryataley Department of Skin and VD, B. J. Govt. Medical College and Hospital, Pune, Maharashtra, India
  • Pallavi P. Patil Department of Skin and VD, B. J. Govt. Medical College and Hospital, Pune, Maharashtra, India
  • Vijay V. Raut Department of Skin and VD, B. J. Govt. Medical College and Hospital, Pune, Maharashtra, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20194691

Keywords:

Sarcoidosis, Noncaseating granuloma, Great imitator, Scar

Abstract

Cutaneous sarcoidosis is an immune-mediated multisystem granulomatous inflammatory disease of unknown etiology. Noncaseating granuloma in pre-existing scars is an uncommon but specific cutaneous manifestation of sarcoidosis. This great imitator may be an under-diagnosed disease in developing countries like India probably because of the diverse range of clinical presentations. Herein we present a 45-year old female with cutaneous sarcoidosis involving scars in addition to de-novo sites.

References

Warrier S, Muhammed Fassaludeen A, Safia B. Cutaneous sarcoidosis with tuberculoid granuloma. Indian J Dermatol Venereol Leprol. 2002;68(5):300-1.

Sharma S, Mohan A. Sarcoidosis in India: not so rare. J Indian Acad Clin Med. 2004;5(1):12-21.

Nunes, H, Bouvry D, Soler, P, Valeyre D. Sarcoidosis. Orphanet J Rare Dis. 2007;2(46):1-8

Mohanty R, Singh S, Bhattamishra A. Cutaneous sarcoidosis without systemic manifestations. Indian J Dermatol. 2009;54(5):80-2.

Sorabjee S, Garje JR. Reactivation of old scars: Inevitably sarcoid. Postgraduate Med J. 2005;81:60–1.

Wei Sheng Joshua L, Cristan H, Paul S. Sarcoidosis: Immunopathogenesis and Immunological Markers. Int J Chronic Dis. 2013;1:1-14.

Richmond B, Ploetze K, Isom J, Chambers-Harris I, Braun NA, Taylor T, et al. Sarcoidosis Th17 cells are ESAT-6 antigen specific but demonstrate reduced IFN gamma expression. J Clin Immunol. 2013;33(2):446–55.

Chuyen T, Naotomo K, Ikuko U, Hiroyuki O. Serological biomarkers of granuloma progression in sarcoidosis. Trends Immunotherapy. 2018;2(2):720-1.

Chavan R, Belgaumkar V, Gosavi A, Chirame S. Sarcoidosis? A Diagnostic Challenge. Int J Sci Res. 2017;6(3):1126-9.

Zhao S, Wang, Q, Cheng, B, Zhu X. Rare scar sarcoidosis: A case report. Experimental Therap Med. 2017;13(4):1535-7.

Downloads

Published

2019-10-21