DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20164041

Correlation between clinical, histopathological and direct immunoflourescence findings in cases of cicatricial alopecias

L. SornaKumar, C. Shanmuga Sekar, S. Vignesh

Abstract


Background: Cicatricial (scarring) alopecias form a group of disorders in which permanent hair loss results from replacement of follicles by fibrosis or hyalinized collagen. The aim was to find the correlation between clinical, histopathological and direct immunofluorescence findings in cicatricial alopecias.

Methods: A total of 20 cases were included in our study. Two 4mm punch biopsies were taken for haematoxylin and eosin (H & E) and DIF respectively. Vertical and horizontal section were cut and stained with haematoxylin and eosin.

Results: After histopathological examination 8 (40%) were confirmed as LPP, 6 (30%) as DLE, 2 (10%) as folliculitis decalvans and 1 (5%) each of acne keloidalis, trichotillomania, CTCL and morphea. Out of 8 confirmed cases of LPP 4 (50%) were positive for direct immunofluorescence and in 6 confirmed cases of DLE 4 (67%) were positive for immunofluorescence.

Conclusions: There was no statistical significance regarding the correlation between clinical, histopathological and immunofluorescence findings.


Keywords


Cicatricial alopecias, Histopathological examination, Immunofluorescence

Full Text:

PDF

References


Thappa DM. Disorders of hairs and nails. In: Thappa DM editor. Essentials in dermatology. 2nd edition. Jaypee Brothers Medical Publishers; 2009: 189-197.

Sperling LC, Cowper SE. The histopathology of primary cicatricial alopecia. Semin Cutan Med Surg. 2006;25:41-50.

Olsen EA, Bergfeld WF, Cotsarelis G, Price VH, Shapiro J, Sinclair R, et al. Workshop on Cicatricial Alopecia. Summary of North American Hair Research Society (NAHRS)-sponsored Workshop on Cicatricial Alopecia, Duke University Medical Center, February10 and 11, 2001. J Am Acad Dermatol. 2003;48:103–10.

Rigopoulos D, Stamatios G, Ioannides D. Primary scarring alopecias. Curr Probl Dermatol. 2015;47:76-86.

Solomon AR. The transversely sectioned scalp biopsy specimen: the technique and an algorithm for its use in the diagnosis of alopecia. Adv Dermatol. 1994:9:127–57.

Headington JT. Cicatricial alopecia. Dermatol Clin. 1996:14:773–82.

Templeton SF, Solomon AR. Scarring alopecia: a classification based on microscopic criteria. J Cutan Pathol. 1994:21:97–109.

Annessi G, Lombardo G, Gobello T, Puddu P. A clinicopathologic study of scarring alopecia due to lichen planus: comparison with scarring alopecia in discoid lupus erythematosus and pseudopelade. Am J Dermatopathol. 1999:21:324–31.

Jordon RE. Subtle clues to diagnosis by immunopathology. Scarring alopecia. Am J Dermatopathol. 1980:2:157–9.

Kulthanan K, Jiamton S, Varothai S, Pinkaew S, Sutthipinittharm P. Direct immunofluorescence study in patients with lichen planus. Int J Dermatol. 2007;46:1237-41.

Shahidullah M, Lee YS, Khor CJ, Ratnam KV. Chronic discoid lupus erythematosus: an immunopathological and electron microscopic study. Ann Acad Med Singapore. 1995;24:789–92.

Thakur BK, Verma S, Raphael V. Clinical Trichoscopic and Histopathological features of Primary Cicatricial Alopecias. A Retrospective Observational Study at a Tertiary care center in North East India. Int J Tichology. 2015:7:107-12.