Cutaneous manifestations of underlying malignancies presenting to a tertiary care teaching hospital

Authors

  • Krishna Rajesh Kilaru Department of Dermatology Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Andhra Pradesh, India
  • Keerthana Kaja Department of Dermatology Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Andhra Pradesh, India
  • Venkateswara Rao Garimella Department of Dermatology Venereology and Leprosy, NRI Medical College and General Hospital, Chinakakani, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20185512

Keywords:

Cutaneous manifestations, Carcinoma, Internal malignancy, Neoplasm, Paraneoplastic dermatoses

Abstract

Background: The skin is the largest organ in the human body. Many types of cancers can cause lesions to appear on the skin. An association between systemic malignancy and cutaneous manifestations has long been recognized. Recognition of these lesions is important for diagnosis at early stages and hence we analyzed the presentation of various skin manifestations in relation to various malignancies.

Methods: We did a prospective study from June 2016 to November 2017 on 50 confirmed cases of internal malignancy with skin manifestations attending the DVL and Oncology OPD of NRI Medical College and General Hospital and Cancer Institute. Detailed history, cutaneous examination, and investigations were done.

Results: Study population included 23 males and 27 females. The majority of cases (34%) were aged above 60 years. In females, reproductive tract malignancies were the highest (37%). In males, Non-Hodgkin's lymphoma (17.3%) and carcinoma rectum (17.3%) were commonly seen. Generalized pruritus was the major presenting cutaneous manifestation (16.4%). Paraneoplastic dermatoses were the most frequent cutaneous markers (67.2%).

Conclusions: Cutaneous manifestation from an internal malignancy is a relatively uncommon phenomenon. But at times, they may be the only presenting feature. Cutaneous paraneoplastic syndromes are important clinical markers that may precede or occur simultaneously or after the diagnosis of a given neoplasm and recognizing them may lead to a higher chance of cure and better prognosis for the patient.

References

Montagna W. The skin. Sci Am. 1965;212:56-66.

Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol. 1993;29(2):228-36.

Hu SC, Chen GS, Lu YW, Wu CS, Lan CC. Cutaneous metastases from different internal malignancies: a clinical and prognostic appraisal. J Eur Acad Dermatol Venereol. 2008;22(6):735-40.

Wright TS. Cutaneous manifestations of malignancy. Curr Opin Pediatr. 2011;23(4):407-11.

Chopra R, Chhabra S, Samra SG, Thami GP, Punia RP, Mohan H. Cutaneous metastases of internal malignancies: a clinicopathologic study. Indian J Dermatol Venereol Leprol. 2010;76(2):125-31.

Kaplan RP. Specific cutaneous manifestations of internal malignancy. Adv Dermatol. 1986;1:3-42.

Pipkin CA, Lio PA. Cutaneous manifestations of internal malignancies: an overview. Dermatol Clin. 2008;26(1):1-15.

Sariya D, Ruth K, Adams-McDonnell R, Cusack C, Xu X, Elenitsas R, et al. Clinicopathologic correlation of cutaneous metastases: experience from a cancer center. Arch Dermatol. 2007;143(5):613-20.

Rajagopal R, Arora PN, Ramasastry CV, Kar PK. Skin changes in internal malignancy. Indian J Dermatol Venereol Leprol. 2004;70(4):221.

Kleyn CE, Lai-Cheong JE, Bell HK. Cutaneous manifestations of internal malignancy: diagnosis and management. Am J Clin Dermatol. 2006;7(2):71-84.

Badwe RA, Dikshit R, Laversanne M, Bray F. Cancer incidence trends in India. Jpn J Clin Oncol. 2014;44(5):401-7.

IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp; 2013.

Ayyamperumal A, Tharini G, Ravindran V, Parveen B. Cutaneous manifestations of internal malignancy. Indian J Dermatol. 2012;57(4):260-4.

Saeed S, Keehn CA, Morgan MB. Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal. J Cutan Pathol. 2004;31(6):419-30.

Kilic A, Gul U, Soylu S. Skin findings in internal malignant diseases. Int J Dermatol. 2007;46(10):1055-60.

Brownstein MH, Helwig EB. Patterns of cutaneous metastasis. Arch Dermatol. 1972;105(6):862-8.

Kraemer KH, Lee MM, Scotto J. Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol. 1987;123(2):241-50.

Somoano B, Tsao H. Genodermatoses with cutaneous tumors and internal malignancies. Dermatol Clin. 2008;26(1):69-87.

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Published

2019-01-25

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Original Research Articles