Quality of life of adolescents with facial acne vulgaris before and after treatment in Ibadan, Nigeria


  • Ehiaghe L. Anaba Department of Medicine, 1Lagos State University Teaching Hospital, Lagos, 2University College Hospital, Ibadan,
  • O. O. Adebola Department of Medicine, 1Lagos State University Teaching Hospital, Lagos, 2University College Hospital, Ibadan,




Adolescent, QOL, Acne vulgaris, Nigeria, Treatment


Background: Adolescent facial acne vulgaris impairs their quality of life (QOL). This impairment of QOL in has been documented to improve with treatment. In Nigerian adolescents who have facial acne vulgaris, it is not known if QOL improves with treatment. The aim was to assess QOL improvement with in adolescents who have facial acne vulgaris. To identify the socio-demographic, CADI QOL items and clinical characteristics related to this QOL improvement.

Methods: This was a cross-sectional comparative study. One hundred and nine adolescents aged 15-20 years clinically examined for facial acne vulgaris. Quality of life before and after 6 weeks of treatment with 10% benzoyl peroxide was assessed using the Cardiff acne disability index. Data was analyzed using SPSS 16. The differences in quality of life scores were tested using non-parametric tests. Level of significance of all tests was p<0.05.

Results: Post-treatment, the median CADI score improved to 2 from a pre-interventional score of 4, p<0.001. Improvement was observed in all the components of the CADI especially with the question, “how bad do you think your acne is now” with a percentage reduction from 81.4% to 54.6% and this improvement was in more males with improvement from 92% to 65%. Also, post-treatment, moderate to severe clinical severity of acne improved from 49.1% to 10.3%, p<0.001.

Conclusions: Treatment of adolescent facial acne leads to improvement of QOL especially in the perception of facial skin appearance and the severity of acne.

Author Biography

Ehiaghe L. Anaba, Department of Medicine, 1Lagos State University Teaching Hospital, Lagos, 2University College Hospital, Ibadan,



Reljić V, Maksimović N, Janković J, Mijović B, Perić J, Janković S. Evaluation of the Quality of life in Adolescents with Acne. Vojnosanit Pregl. 2014;71:634-8.

Jankovic S, Vukicevic J, Djordjevic S, Jankovic J, Marinkovic J. Quality of life among Schoolchildren with Acne: Results of a Cross-sectional Study. Indian J Dermatol Venereol Leprol. 2012;78:454-8.

Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, et al. Guidelines of Care for the Management of Acne Vulgaris. J Am Acad Dermatol. 2016;74:945-73.

Mills OH, Klicman AM, Pochi P, Comite H. Comparing 2.5%, 5%, and 10% Benzoyl Peroxide on Inflammatory Acne Vulgaris. Int. J Dermatol. 1986 25:664-7.

Jian VK, Chopra KL, Dayal S. Comparative Evaluation of Topical Benzoyl Peroxide, Metronidazole and Benzoyl Peroxide-clindamycin Combination in Treatment of Acne Vulgaris. Indian J Dermatol Venereol Leprol. 1998;64:71-4.

Kobayashi M, Kabashima K, Nakamura M, Tokura Y. Effects of Oral Antibiotic Roxithromycin on QOL in Acne Patients. J Dermatol. 2009;36:383-91.

Gollnick HP, Friedrich M, Peschen M, Pettker R, Pier A, Streit V, et al. Effect of adapalene 0.1%/benzoyl peroxide 2.5% Topical Gel on Quality of Life and Treatment Adherence during Long-term Application in Patients with Predominantly Moderate Acne with or without Concomitant Medication - additional Results from the Non-interventional Cohort study ELANG. J Eur Acad Dermatol Venereol. 2015;29(4):23-9.

Zaraa I, Belghith I, Ben Alaya N, Trojjet S, Mokni M, Ben Osman A. Severity of Acne and its Impact on Quality of life. Skinmed. 2013;11:148-53.

Feldman SR, Fried RG, Herndon JH Jr, Johnson L, Preston N, Gottschalk RW, et al. Digital videography assessment of patients' experiences using adapalene-benzoyl peroxide gel in the treatment of acne vulgaris. J Drugs Dermatol. 2012;11:919-25.

Hayashi N, Kawashima M. Efficacy of Oral Antibiotics on Acne Vulgaris and their Effects on Quality of Life: a Multicenter Randomized Controlled Trial Using Minocycline, Roxithromycin and Faropenem. J Dermatol. 2011;38:111-9.

Ogedegbe EE, Henshaw EB. Severity and Impact of Acne Vulgaris on the Quality of Life of Adolescents in Nigeria. Clin Cosm Investig Dermatol. 2014;7:329–34.

Yahya H. Acne Vulgaris in Nigerian Adolescents- Prevalence, Severity, Beliefs, Perceptions and Practices. Int J Dermatol. 2009;48:498-505.

Finlay AY. Cardiff Acne Disability Index. Available at: www.dermatology.org.uk. Accessed on 24 July 2009.

Walker N, Lewis-Jones MS. Quality of Life and Acne in Scottish Adolescent School Children: Use of the Children’s Dermatology Life Quality Index And The Cadiff Acne Disability Index. J Eur Acad Dermatol Venereo. 2005;20:45-50.

Tan JKL, Tang J, Fung K et al. Development and Validation of a Comprehensive Acne Severity Scale (CASS). J Cutan Med Surg. 2007;11:211-6.

Statistical Package for Social Sciences (SPSS) Version 16.0 for Windows; Released 2006. Chicago: SPSS Inc. Available at: http://www.spss. en.softonic.com. Accessed on 4 February 2011.

Tasoula E, Gregoriou S, Chalikias J, Lazarou D, Danopoulou I, Katsambas A, et al. The impact of acne vulgaris on quality of life and psychic health in young adolescents in Greece. Results of a Population Survey. An Bras Dermatol. 2012;87:862-9.

Kaymak Y, Taner E, Taner Y. Comparism of Depression, Anxiety and Life Quality in Acne Vulgaris Patients who were Treated with either Isotretinoin Or Topical Agents. Int J Dermatol. 2009;48:41-6.

Law MP, Chuh AA, Lee A, Molinari N. Acne Prevalence and Beyond: Acne Disability and its Predictive Factors among Chinese Late Adolescents in Hong Kong. Clin Exp Dermatol. 2010;35:16-21.






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