DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20170794

A study on histopathological changes in lesions of vitiligo in Karnataka population

Girish V. Nagaral, Karibasappa .

Abstract


Background: Vitiligo is considered to be symptom less and its presentation is boundless varying from isolated focal lesion to bizarre generalized lesions. The present study was undertaken to study the histopathological changes in lesions of vitiligo in south Indian population.

Methods: 150 patients with mild to moderate vitiligo features attending the outpatient department of Dermatology, Venereology and Leprology at Chitageri General Hospital and Bapuji Hospital attached to J.J.M Medical College, Davengere were utilized to study the histopathological features in vitiligo and its association with other diseases.

Results: Destruction of melanocytes at dermo-epidermal junction was noted. We have observed presence of melanocytes in the basal layer of the epidermis on left side of the lesion, whereas decreased melanocytes in the basal layer of the epidermis on the right side of the same lesion in the present study. Dermis with mild perivascular lymphocytic infiltration and acanthosis along with mono nuclear cell infiltration in the upper dermis was observed.

Conclusions: The present study gives better knowledge to the clinicians about the lesions of vitiligo and its pathogenesis.


Keywords


Epidermis, Melanocytes, Vitiligo

Full Text:

PDF

References


Mosher DB, Fitzpatrick TB, Ortonne JP, Hori Y. Hypomelanoses and hypermelanoses. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, Fitzpatrick TB eds. Fitzpatrick’s Dermatology in General Medicine. 5th ed. New York: McGraw-Hill; 1999: 945–1017.

Hann SK, Chun W. Autocytotoxic hypothesis for the destruction of melanocytes as the cause of vitiligo. In: Hann SK, Nordlund J, editors. Vitiligo. Oxford: Blackwell Science Ltd; 2000: 137.

Goldman L, Moraites RS, Kitzmiller KW. White spots in biblical times. A background for the dermatologist for participation in discussions of current revisions of the bible. Arch Dermatol. 1966;93(6):744-53.

Rao DS, Susheela AK. Tissue Sulphydryl Groups and Ascorbic Acid in Vitiligo. Indian Journal of Dermatol Venereol and Leprol. 1979;45(3):214-76.

Dutta AK, Dutta PK, Dhar S. Pigmentary disorders: chemical induced disorders. In: Valia RG, Valia AR, editors. IADVL Textbook and Atlas of Dermatology, 2 nd ed. Mumbai (India): Bhalani Publishing House; 2001: 604-605.

Behl PN, Bhatia RK. 400 cases of vitiligo - A clinicotherapeutic analysis. Indian J Dermatol.1971;17:51–53.

Spielvogel RL, Kantor GR. Pigmentary disorders of the skin. in: D.E. Elder, R. Elenitsas, B.L. Johnson Jr., G.F. Murphy (Eds.) Lever's histopathology of the skin. 9th ed. Lippincott Williams and Wilkins, Philadelphia; 2005: 705–713.

Ortonne JP, Moscher DB, Fitzpatrick TB. Nevusdepigmentosus. In: T.B. Fitzpatrick (Ed.) Vitiligo and other hypomelanoses of hair and skin. Plenum Medical, New York; 1983: 398–411.

Hann SK, Nordlund JJ, editors. 1st ed. Oxford, London: Blackwell Science Ltd. In: Vitiligo: A Monograph on the Basic and Clinical Science; 2000: 1–386.

Pegum JS. Dissociated depigmentation in vitiligo. Significance and therapeutic implications. British journal of Dermatolgy. 1955;67(10):348–350.

Kang S, Sober AJ. Disturbances of melanin pigmentation. In: Moschella SL, Hurley HJ, editors. Dermatology. Philadelphia (PA): WB Saunders; 1992: 1442–1474.

Morohashi M, Hashimoto K, Goodman TF, Jr, Newton DE, Rist T. Ultrastructural studies of vitiligo, Vogt-Koyanagi syndrome, and incontinentia pigmenti achromians. Arch Dermatol. 1977;113(6):755-766.

Mishima, Kawasaki H, Pinkus H. Dendritic cell dynamics in progressive depigmentations. Arch Dermatol. 1972;243:67–87.

Breathnach AS, Bor S, Wyllie LM. Electron microscopy of peripheral nerve terminals and marginal melanocytes in vitiligo. J Invest Dermatol. 1966;47(2):125-40.