Haematological profile of human immunodeficiency virus infected patients


  • C. L. Chitra Department of Dermatology, Madras Medical College, Tamil Nadu
  • R. Manipriya Department of Dermatology, Madras Medical College, Tamil Nadu
  • K. Deepa Department of Dermatology, Madras Medical College, Tamil Nadu




Human immunodeficiency virus, Hematological profile, Anemia, Leukopenia, Thrombocytopenia, Pancytopenia


Background: In India, approximately 6 million populations are affected by human immunodeficiency virus (HIV). Anemia and leukopenia, especially thrombocytopenia is seen commonly in HIV infections. Low CD4+ count and increased viral load are some of the factors associated with increased risk of thrombocytopenia. The aim of the study was to study the hematological changes that occur in HIV infected patients who attend the Institute of Venereology, before starting HAART.

Methods: This cross-sectional study was conducted in the Institute of Venereology, Madras Medical College/Rajiv Gandhi Government General Hospital, Chennai in 100 treatment-naive HIV infected patients. Detailed history and clinical examination was done. Blood samples were collected. Complete blood count, CD4 count, prothrombin time, activated plasma thromboplastin time, peripheral smear etc., were done. Results were collected and analysed.

Results: Out of 100 patients, 56% were males and 43% females and one transgender. Anaemia was detected in 72%patients. 73.5% males and 76.2% females with CD4 count <350/μl were anemic. The commonest anaemia was normochromic normocytic, seen in 65% patients. 7 male and 7 female patients had leukopenia. 81.25%patients with lymphocytopenia had CD4 count <350/μl. 12% males and 4% females had neutropenia. 17% had neutrophilia. Patients in WHO stage I did not have neutropenia. 23% patients had thrombocytopenia. 47% patients with thrombocytopenia were in stage IV. Maximum number of patients with normal platelet count was in stage I.

Conclusions: Haematological abnormalities are a common occurrence during the course of HIV infection. Identifying and treating the haematological changes have great impact on both the morbidity and mortality of HIV infected patients.


Parinitha SS, Kulkarni MH. Haematological changes in HIV infection with correlation to CD4 count. Australasian Med J. 2012;5(3):157–62.

Attili SV, Singh VP, Rai M, Varma DV, Gulati AK, Sundar S. Haematological Profile of HIV patients in relation to immune status. Turk J Haematol. 2008;25:13–9.

Volberding PA1, Lagakos SW, Koch MA, Pettinelli C, Myers MW, Booth DK, et al, Zidovudine in asymptomatic Human Immunodefiency Virus infection. N Eng Med. 1990;322:941–9.

Mocroft A1, Kirk O, Barton SE, Dietrich M, Proenca R, Colebunders R, et al. Anaemia is an independent predictive marker for clinical prognosis in HIV infected patients from Europe. ADS. 1999;13:943–50.

Holland SM, Gallin J. Disorders of granulocytes and monocytes, Harrison’s principles of internal medicine volume -1. 16th edition. McGraw–Hill professional; USA: 2004: 351.

Treacy M, Lai L, Costello C, Clark A. Peripheral blood and bone marrow abnormalities in patients with HIV related disease. Br J Haematol. 1987;65:289.

Dikshit B, Wanchu A, Sachdeva RK, Sharma A, Das R. Profile of haematological abnormalities of Indian HIV infected individuals. BMC Blood Disorders. 2009;9:5.

Mgogwe H, Semvua H, Msangi R, Mataro C, Kajeguka D, Chilongola J. The evolution of haematological and biochemical indices in HIV patients during a six month treatment period. Afr Health Sci. 2012;12 (1):2–7.

Turbadkar D, Mathur M, Gaikwad S. Prevalence of syphilis among HIV seroreactive patients. IJSTD. 2007;28(2):91-3.

Chawhan SM, Bhat DM, Solanke SM. Dermatological manifestations in human immunodeficiency virus infected patients: Morphological spectrum with CD4 correlation. IJSTD. 2013;34(2):89-94.

Halder S, Banerjee S, Halder A, Pal PR. Skin disease in HIV infected patients: Impact of immune status and histological correlation. IJSTD. 2012;33(1):65-7.

Cleeland CS, Demetri GD, Glaspy J, Cella DF, Portenoy RK, Cremieux P-Y, et al. Identifying haemoglobin level for optimal quality of life:results of incremental analysis. Orean J Hematology 2011;46(4):253-7.

Sullivan PS, Hanson DL, Chu SY, Jones JL, Ward JW. Epidemiology of anaemia in HIV infected persons. Results from the multistate adult and adolescent spectrum of HIV disease surveillance project. The adult / adolescent spectrum of disease group. Blood. 1998;91:301–8.

Treacy M, Lai L, Costello C, Clark A. Peripheral blood and bone marrow abnormalities in patients with HIV disease. British J Haematol. 1987;65:289-94.

World Health Organization (2008). Worldwide prevalence of anaemia 1993–2005. Geneva: World Health Organization; 2009.

Kasthuri AS, Sharma S, Kar PK. A study of haematological manifestations of HIV Infection. Indian J Sex Transm Dis. 2006;27:1-9.

Denue BA, Gashau W, Bello HS, Kida IM, Bakki B, Ajayi B. Relationship between some haematological abnormalities, degree of immunosuppression and viral load in treatment naïve HIV-1 infected patients. East Mediterr Health J. 2013;19(4):14.

Kaloutsi V, Kohlmeyer U, Maschek H, Nafe R, Choritz H, Amor A, et al. Comparison of bone marrow and hematologic findings in patients with human immunodeficiency virus infection and those with myelodysplastic syndromes and infectious diseases. Am J Clin Pathol. 1994;101(2):123-9.

Patwardhan MS, Gowlikar AS, Abhyankar JR, Atre MC. Hematologic profile of HIV positive patients. Ind J Pathol Microbiol. 2002;45(2):147-50.

Costello C. Haematological abnormalities in human immunodeficiency virus (HIV) disease. J Clin Pathol. 1988;41:711-4.

Choi SY, Kim I, Kim NJ, Lee SA, Choi YA, Bae JY, et al. Hematological manifestations of human immune deficiency virus infection and the effect of highly active antiretroviral therapy on cytopenia. Korean J Hematol. 2011;46(4):253–7.

Erhabor O, Ejele OA, Nwauche CA, Buseri FI. Some haematological parameters in human immunodeficiency virus infected Africans. Niger J Med. 2005;14(1):33-8.

Frontiera M, Myers AM. Peripheral blood and bone marrow abnormalities in the acquired immunodeficiency syndrome. West J Med. 1987;147:157-160.

Chug S, Bela N. Hematological manifestation in HIV. Post Graduate Med. 1998;22:58-73.

Bain BA. Pathogenesis and pathophysiology of anaemia in HIV infection. Curr Opin Hematol. 1999;6(2):89-93.






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