DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20190237

Diabetes mellitus and hepatitis c in generalised lichen planus: a case control study

K. Parimalam, R. Sowmiya, S. Mithra

Abstract


Background: Prevalence of lichen planus (LP) and generalised lichen planus (GLP) is about 2.6% and 1% respectively. Various studies have shown higher prevalence of Diabetes Mellitus (DM) and stronger association between Hepatitis-C virus (HCV) and LP. The main objective of this study was to predict the prevalence of DM and HCV in patients with GLP before starting steroids.

Methods: A case-control study was conducted with 33 patients in each group for one year period. Case group included patients with GLP excluding oral LP and drug induced lichenoid dermatitis. Control group included patients with other skin conditions and not on steroids. Preliminary details and history of DM and HCV were collected. Random blood sugar and Anti-HCV were done.

Results: The proportion of patients with GLP was higher in women compared to men (63.6% vs. 36.3%). Highest prevalence was observed in the age group 35-45 years for both genders. On stratification by sex, odds of having GLP in women are 0.76 times lower among diabetics compared to non-diabetics whereas no association in males. There was no association between GLP and HCV in both sexes.

Conclusions: There is no significant association between Diabetes mellitus and Hepatitis-C infection with GLP. Future study is planned with larger sample size for a definite conclusion.


Keywords


Diabetes mellitus, Hepatitis-C, Generalised lichen planus

Full Text:

PDF

References


Gupta S, Jawanda MK. Oral Lichen planus: An update on Etiology, Pathogenesis, Clinical Presentation, Diagnosis and Management. Indian J Dermatol. 2015;60(3):222-9.

Ustaine RP, Tintigan M. Diagnosis and treatment of Lichen planus. Am Fam Physician. 2011;84(1):53-60.

Varma K, Shukla P. Association of diabetes mellitus in patients with Lichen planus. Indian J Clin Experimental Dermatol. 2017;3(1):14-6.

Habib F, Stoebner PE, Picot E, Peyron JL, Meynadier J, Meunier L. Narrow band UVB phototherapy in the treatment of widespread lichen planus. Ann Dermatol Venereol. 2005;132(1):17-20.

Agay-Abensour L, Benamouzig R, deBelilovsky C, Cordoliani F, Halphen M, Rambaud JC. Lichen planus during chronic Hepatitis-C treated with interferon alpha. Gastroenterol Clin Biol. 1992;16(6-7):610-1.

Lowe Nj, Cudwoth AG, Clough SA, Bullen MF. Carbohydrate metabolism in lichen planus. Br J Dermatol. 1976;95:9-12.

Lundstrom IMC, Anneroth GB, Holmberg K. Candida in patients with oral lichen planus. Int J oral Surg 1984;13:226-38.

Bagan JV, Donat JS, Penarrocha M, Milian MA, Sanchis JM. Oral lichen planus and diabetes mellitus. A clinic-pathological study. Bill Group Int Rech Sci Stomatol et Odontol. 1993;36:3-6.

Seyhan M, Zcan HO, Sahin I, Bayram N, Karincaoglu Y. High prevalence of glucose metabolis disturbance in patients with lichen planus. Diabetes Res Clin Pract. 2007;77:198-20.

Romero MA, Seoane J, Varela-Centelles P, Diz-Dios P, Garcia-Pola MJ. Prevalence of diabetes mellitus amongst oral lichen planus patients Clinical and pathological characteristics. Med Oral. 2002;7(2):121-9.

Shengyuan L, Songpo Y, Wen W, Wenjing T, Haitao Z, Binyou W. Hepatitis C virus and lichen planus: a reciprocal association determined by a meta-analysis. Arch Dermatol. 2009;145(9)1040-7.

Mast EE, Alter MJ, Margolis HS. Strategies to prevent and control hepatitis B and C virus infections: a global perspective. Vaccine. 1999;17(13-14):1730-3.

Mozaffari HR, Sharifi R, Sadeghi M. Prevalence of Oral Lichen planus in Diabetes Mellitus: a Meta-Analysis study. Acta Inform Med. 2016;24(6):390-3.

Petrou-Amerikanou C, Maropoulos AK, Belazi M, Karamitsos D, Papanayotou P. Prevalence of oral lichen planus in diabetes mellitus according to the type of diabetes. Oral Dis.1998;4(1):37-40.

Serrano-Sanchez P, Bagan JV, Jimenez-Soriano, Sarrion G. Drug induced oral lichenoid reactions: A literature review. J Clin Exp Dent. 2010;2:71-5.

Bytzer P, Talley NJ, Hammer J, Young LJ, Jones MP, Horowitz M. GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications. Am J Gastroenterol. 2002;97(3):604-11.

Began-Sebastian JV, Milian-Masanet MA, Penarrocha M, Jimenez Y. A clinical study of patients with oral lichen planus. J Oral Maxillofac Surg. 1992;50:116-8.