Correlation of serum calcium levels with severity of psoriasis


  • Sunil Chaudhari Department of Dermatology, Venereology and Leprosy, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
  • Sushil Rathi Department of Dermatology, Venereology and Leprosy, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India



Psoriasis, Serum calcium, Hypocalcemia


Background: Recently it has been observed that psoriasis can be successfully controlled by use of vitamin D. This has attracted the curiosity into research on psoriasis and vitamin D as well as role of calcium supplements in the control of psoriasis. Studies have shown that psoriasis risk factor is hypocalcemia. The objective of the study was to analyse serum calcium levels in patients of psoriasis and correlation with severity of psoriasis in comparison with control subjects without psoriasis.

Methods: This study recruited 80 subjects, of psoriasis (age and sex control subjects without psoriasis) attending Skin and STD department, Government Medical College Amritsar, Punjab. Both patients and controls studied during period of 2 year from June 2015 to May 2017.

Results: Serum calcium levels were significantly lower in psoriasis patients than in controls. Serum calcium levels values in patients of mild severity (PASI <10), moderate severity (PASI: 11-20) and severe (PASI >21) were 9.00±0.20, 8.93±0.24 & 8.98±0.22 respectively.

Conclusions: Serum calcium levels were found lower in psoriasis patients and there were no correlation with severity of psoriasis. Hypocalcemia is a risk factor of psoriasis.


Burns T, Grifiths C, Cox N, Breathnach S. In: Rooks Textbook of Dermatology, 8th ed. Vol: 1; 2010: 1

Christophers E. The immunopathology of psoriasis. Int Arch Allergy Immunol 1996;110:199-206.

Gupta A, Arora T, Jindal A, Bhadoria A. Efficacy of narrowband ultraviolet B phototherapy and levels of serum vitamin D3 in psoriasis: A prospective study. Indian Dermatol Online J. 2016;7(2):87.

Cook J, Thiers B. Serum calcium and phosphorus measurements in patients with psoriasis: a retrospective review. J Eur Acad Dermatol Venereol. 1993;2(1):18–21.

Plavina T, Hincapie M, Wakshull E, Subramanyam M, Hancock WS. Increased plasma concentration of cytoskeletal and Ca2+ -binding proteins and their peptides in psoriasis patients. Clin Chem. 2008;54:1805-14.

Braun GS, Witt M, Mayer V, Schimid H. Hypercalcemia caused by vitamin D3 analogue in psoriasis treatment. Int J Dermatol. 2007;46:1315-7.

Wolters M. Diet and Psoriasis: Experimental Data and Clinical Evidence: Oxidative Stress and Antioxidant. Br J Dermatol. 2005;153(4):706-14.

Duweb G, Alhaddar J, Abuhamida M. Psoriasis vulgaris once –versus twice-daily application of calcitriol cream. Int J Tissue React. 2005;27:155-8.

Morimotos S, Yoshikawa K, Fukuo K, Shiraishi T, Koh E, Imanaka S, et al. Inverse relation between severity of psoriasis and serum 1,25-dihydroxy-vitamin D level. J Dermatol Sci. 1990;1(4):277-82.

Zhai Z, Chen L, Yang H, Yan J, Wang C, Yang J, et al. Can pretreatment serum calcium level predict the efficacy of methotrexate in the treatment of severe plaque psoriasis? J Am Acad Dermatol. 2015;73(6):991-7.e3.

Qadim HH, Goforoushan F, Nejad SB, Goldust M. Studying the Calcium Serum Level in Patients Suffering from Psoriasis. Pak J Biological Sci. 2013;16:291-4.

Stewart AF, Battaglini-Sabetta J, Millstone L. Hypocalcemia-induced pustular psoriasis of von Zumbusch. New experience with an old syndrome. Ann Intern Med. 1984;100(5):677-80.

Lebwohl M, Ortonne JP, Andres P, Briantais P. Calcitriol ointment 3 microg/g is safe and effective over 52 weeks for the treatment of mild to moderate plaque psoriasis. 2009;83(4):205-12.

Kitamura K, Kanasashi M, Suga C, Saito S, Yoshida S, Ikezaqa Z. Cutaneous reactions induced by calcium channel blocker: high frequency of psoriasiform eruptions. J Dermatol. 1993;20(5):279-86.






Original Research Articles