Psoriasis and metabolic syndrome: hospital based cross sectional study of prevalence and correlation in a rural south Indian population

Dhanalakshmi Kathirvel, Vaishnavi Dhandapani, Baskaran R., Gladius Jennifer H.


Background: Psoriasis is a chronic inflammatory skin disease that affects 1-3% of the population. Recent studies have reported that psoriasis is associated with metabolic disorders, including obesity, dyslipidaemia and diabetes. The aim of the present study was to investigate the prevalence of metabolic syndrome (MS) in psoriasis and to evaluate the association with severity and duration of psoriasis

Methods: This was a hospital based cross sectional study that involved 60 patients with psoriasis evaluated for MS. Statistical analysis was done by SPSS version 16.0 software. Percentages, mean, standard deviation, correlation, chi-square test, t test were calculated at 5% level of significance.

Results: 20% of patients had MS which is comparable to the normal population. 60% of the patients in our study are obese which is directly correlating with MS. There is significant increase in MS as age (p =0.01), duration of psoriasis (p =0.03), BMI (p =0.0001), waist circumference (p =0.0001) increases.

Conclusions: There is 20% association of psoriasis with MS. There is no gender predisposition and no association between the severity of psoriasis and metabolic syndrome. There is minimal relationship between the duration of psoriasis and metabolic syndrome. Obesity is the commonest factor related to psoriasis, diabetes and MS which should be taken care of by diet, exercise and lifestyle modification. 


Psoriasis, Metabolic syndrome, Dyslipidaemia

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Nisa N, Qazi MA. Prevalence of metabolic syndrome in patients with psoriasis. Indian J Dermatol Venereol Leprol. 2010;76:662-5.

Iizuka T. Psoriasis and metabolic syndrome. Journal of Dermatology. 2012;39:212-8.

Kim GW, Par HJ, Kim HS, Su-Han Kim SH, Ko HC, Kim BS, et al. Analysis of cardiovascular Risk Factors and Metabolic Syndrome in Korean Patients with Psoriasis. Ann Dermatol. 2012;24(1):11-5.

Langan SM, Seminara NM, Shin DB, Troxel AB, Kimmel SE , Mehta NN, et al. Prevalence of metabolic syndrome in patients with psoriasis. A population-based study in the United Kingdom. J Invest Dermatol. 2012;132(3):556–62.

Mehta NN, Yu YD, Pinnelas R, Krishnamoorthy P, Shin DB, Troxel AB, et al. Attributable Risk Estimate of Severe Psoriasis on Major Cardiovascular Events. Am J Med. 2011;124(8):775.

Enas EA, Mohan V, Deepa M, Farooq S, Pazhoor S, Chennikkara H. The metabolic syndrome and dyslipidemia among Asian Indians: A population with high rates of diabetes and premature coronary artery disease. J Cardiometab Syndr. 2007;2:267-75.

Rickson RP, Sangeeta TA, Prema KV. A study of prevalence of diabetes, insulin resistence, lipid abnormalities and cardiovascular risk factors in patients with chronic plaque psoriasis. Indian J Dermatol. 2011;56(5):520–6.

Gisondi P, Tessari G, Conti A. Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case–control study. British Journal of Dermatology. 2007;157:68–73.

Sommer DM, Jenisch S, Suchan M, Christophers E, Weichenthal M. Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res. 2006;298:321-8.

Ramachandran A, Snehalatha C, Satyavani K, Sivasankari S, Vijay V. Metabolic syndrome in urban Asian Indian adults: A population study using modified ATP III criteria. Diabetes Res Clin Pract. 2003;60:199–204.

Malhotra SK, Dhaliwal GS, Puri KJPS, Gambhir ML, Mahajan M. An insight into relationship between psoriasis and metabolic syndrome. Egyptian dermatology Online Journal 2011;7(2):5.

Cohen AD, Sherf M, Vidavsky L, Vardy DA, Shapiro J, Meyerovitch J. Association between psoriasis and metabolic syndrome. Dermatology. 2008;216:152-5.

Nigam P, Dayal SG. Diabetic status in psoriasis. Indian J Dermatol Venereol Leprol. 1979;4(5):171–4.

Madanagobalane S, Anandhan S. Prevalence of metabolic syndrome in south Indian patients with psoriasis and relation between disease severity and metabolic syndrome: A hospital based case-control study. Indian Journal of Dermatology. 2012;57:353-7.