DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20175702

Study of profile of polymorphous light eruption at a tertiary referral center

Amruta A. Kulkarni, Yoganand J. Phulari

Abstract


Background: Polymorphous light eruption (PMLE) is the most common endogenous photodermatosis.But only few studies are available from India regarding this photodermatosis. It is common in women, often worse in spring. The lesions are usually monomorphous in an individual patient but polymorphic in different patients.

Methods: The study was conducted between October 2010 and March 2012. 78 patients with clinical diagnosis of PMLE, who attended Dermatology OPD at Dr. D. Y. Patil Hospital and Research Institute, Kolhapur were included in present study. Detailed history, clinical examination and relevant investigations were done. The collected data were tabulated and analyzed.

Results: The age group of the patients ranged from 3 years to 58 years. Maximum number of patients were seen in the age group of 21-30 years. The female to male ratio was found to be 1.78:1.Onset of PMLE lesions was maximum in the month of March. Majority of patients were housewives. Itching was the most common symptom. In 32.05% of patients, lesions developed within 30 minutes of sun exposure. Family history of PMLE was present in 6 (7.69%) cases.

Conclusions: PMLE was found most commonly in second and third decades of life since people in this age group are more exposed to sun, more in women probably because of hormonal differences.The maximum number of cases was noted in the month of March when the sun exposure is high. The maximum cases in housewives, as they have short intermittent sun exposure and absence of hardening phenomenon. Higher incidence was noted with cotton clothing as it has lower UV protection. Most of the patients developed lesions within 30 minutes of sun exposure. History of recurrence of PMLE was noted in 30 patients. Only 6 patients gave family history of PMLE because of milder nature of the disease along with difference in clothing and working environment.


Keywords


Polymorpohous light eruption, Photodermatoses, Photosensitivity

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References


Yashar SS, Lim HW. Classification and evaluation of photodermatoses. Dermatol Ther. 2003;16(1):1-7.

Honigsmann H. Polymorphous light eruption. Photodermatol Photoimmunol Photomed. 2008;24:155-61.

Wolf P, Byrne SN, Gruber-Wackernagel A. New insights into the mechanisms of polymorphic light eruption: resistance to ultraviolet radiation-induced immune suppression as an aetiological factor. Experimental Dermatol. 2009;18:350–6.

Fotiades J. Soter NA, Lum HW. Result of evaluation of 203 patients for photosensitivity in 3 years period. J Am Acad Dermatol. 1995;33:597-602.

Khoo SW, Tay YK, Tham SN. Photodermatoses in a Singapore skin referral centre. Clin Exp Dermatol. 1996;21:263-8.

Sharma L, Basnet A. A clinicoepidemiological study of polymorphic light eruption. Indian J Dermatol Venereol Leprol. 2008;74:15-7.

Millard TP, Bataille V, Snieder H, Spector TD, McGregor JM. The heritability of polymorphic light eruption. J Invest Dermatol. 2000;115:467-70.

McGregor JM, Grabczynska S, Vaughan R, Hawk JL, Lewis CM. Genetic modeling of abnormal photosensitivity in families with polymorphic light eruption and actinic prurigo. J Invest Dermatol. 2000;115:471-6.

Hawk JLM, Young AR, Ferguson J. Cutaneous Photobiology. In: Burns T, Breathnach S, Cox N, Griffiths C. Rook’s textbook of dermatology. 8th edition. West Sussex Wiley-Blackwell publications; 2010: 29.9-29.13.

Jansen CT. Heredity of chronic polymorphous light eruptions. Arch Dermatol. 1979;115:165-9.

Epstein JH. Polymorphous light eruption. Dermatol Clin. 1986;4:243–51.

Jansen CT. The natural history of polymorphous light eruptions. Arch Dermatol. 1979;115:165–9.

Naleway AL, Greenlee RT, Melski JW. Characteristics of diagnosed polymorphous light eruption. Photodermatol Photoimmunol Photomed. 2006;22:205–7.

Holzle E. Polymorphous light eruption. In: Krutmann J, Elmets CA, editors. Photoimmunology. London: Blackwell Science; 1995: 167-174.

Boonstra HE, van Weelden H, Toonstra J, van Vloten WA. Polymorphous light eruption: a clinical, photobiologic, and follow-up study of 110 patients. J Am Acad Dermatol. 2000;42:199–207.

Mastalier U, Kerl H, Wolf P. Clinical, laboratory, phototest and phototherapy findings in polymorphic light eruptions: A retrospective study of 133 patients. Eur J Dermatol. 1998;8(8):554-9.

Pullabatla P, Kaliyaperumal KP, Sidhu U. A Clinico-Pathological Study of Polymorphous Light Eruption. J Cosmetics, Dermatological Sci Applications. 2012;2:219-223.

Battie C, Verschoore M. Cutaneous solar ultraviolet exposure and clinical aspects of photodamge. Indian J Dermatol Venereol Leprol. 2012;78:9-14.

Rhodes LE, Bock M, Janssens AS, Ling TC, Anastasopoulou L, Antoniou C, et al. Polymorphic light eruption occurs in 18% of Europeans and does not show higher prevalence with increasing latitude: multicenter survey of 6895 individuals residing from Mediterranean to Scandinavia. J Invest Dermatol. 2010;130:626–8.

Aubin F. Why Is Polymorphous Light Eruption so Common in Young Women? Arch Dermatological Res. 2004;296(5):240-1.

Jansen CT, Darvonen J. Polymorphous light eruption. A seven year follow up evaluation of 114 patients. Arch Dermatol. 1984;120:862-4.

Guarrera M, Cardo P, Rebora AE, Schena D. Polymorphous light eruption and benign summer light eruption in Italy. Photodermatol Photoimmunol Photomed. 2010;27:35–9.

Millard TP, Bataille V, Snieder H, Spector TD, McGregor JM. The heritability of polymorphic light eruption. J Invest Dermatol. 2000;115:467-70.

Ros AM, Wennersten G. Current aspects of Polymorphous light eruptions in Sweden. Photodermatol. 1986;3:298-302.