Herbal conjugation for increased binding of zinc pyrithione on hair: new treatment approach

Authors

  • Amruthavalli G. V. R&D, Dr. JRK’s Research and Pharmaceuticals Pvt Ltd, Chennai, Tamil Nadu
  • Satarupa Mukherjee Department of Microbiology, Dr. JRK’s Research and Pharmaceuticals Pvt Ltd, Chennai, Tamil Nadu
  • Gayathri Rajagopal Dr. JRK’s Research and Pharmaceuticals Pvt Ltd, Chennai, Tamil Nadu

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20180140

Keywords:

Dandruff, Zinc pyrithione, Hair perforation test, Fungal colonization, Herbal, Fungal infections, Anti-dandruff shampoo

Abstract

Background: Fungal infections of scalp and hair are common now-a-days and emerging. There are various medicaments for scalp mycosis. Shampoos attained importance due ease of use. But they underperform or perform poorly due to the likely short contact time as most of them are wash off products. Selective binding of the anti-fungal agents over hair in short contact time alone can address the problem of scalp mycosis.

Methods: AAS was done to establish the adhesion of anti-fungal agents over hair and the rate of fungal colonization over hair and the extent of hair perforation were used to establish the effect of herbal conjugation in providing anti-fungal activity and blocking the parasitic conversion of fungi.

Results: Zinc adhesion was significant in Verdura anti scaling scalp shampoo and zinc pyrithione treated and no colonization and perforation was observed in Verdura anti scaling scalp shampoo and zinc pyrithione treated hair samples.

Conclusions: Present study deals with the importance of herbal conjugation technology in enhancing the targeted delivery of zinc pyrithione over hair. The present technology is important for achieving greater anti-fungal benefits from wide range of toiletry preparations due to their short contact time. 

References

Isaiah S, Karthikeyan S. Review on scientific insight of dandruff/seborrheic dermatitis: a common skin disorder. Int J Pharm Bio Sci. 2015;6(1):742-9.

Manuel F, Ranganathan S. A New Postulate on Two Stages of Dandruff: A Clinical Perspective. Int J Trichol. 2011;3(1):3-6

Ranganathan S, Mukhopadhyay. Dandruff: The most commercially exploited skin disease. T. Indian J Dermatol. 2010;55:130–4.

Draelos ZD, Kenneally DC, Hodges LT, Billhimer W, Copas M, Margraf C. A Comparison of Hair Quality and Cosmetic Acceptance Following the Use of Two Anti-Dandruff Shampoos. J Investig Dermatol Symp Process. 2005;10:201–4.

Mutap A, Huremović J, Nuhanović M. Analysis of Some Metals in Human Hair by the AAS Method. Bulletin of the Chemists and Technologists of Bosnia and Herzegovina. 2016;46:19-26.

Sinski JT, Avermaete DV, Kelley LM. Analysis of Tests Used to differentiate Trichophyton rubrum from Trichophyton mentagrophytes. Journal of Clinical Microbiology. 1981:13(1):62-5.

Leyden JJ, McGinley KJ, Klingman AM. Role of microorganisms in dandruff. Arch Dermatol. 1976;112:333–8.

Piérard-Franchimont C, Goffin V, Decroix J, Piérard GE. A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis. Skin Pharmacol Physiol. 2002;15:434–41.

Shin H, Kwon OS, Won CH, Kim BJ, Lee YW, Choe YB. Clinical efficacies of topical agents for the treatment of seborrheic dermatitis of the scalp: a comparative study. J Dermatol. 2009;36(3):131-7.

Aruna V, Rajagopal G. Secret Behind the Safety of the Siddha Products: An Insight from Metal Chelation. Research and Reviews: A Journal of Unani, Siddha and Homeopathy. 2016;3(2):24–7.

Hughes GJ, Patel PN, Saxena N. Effect of acetaminophen on international normalized ratio in patients receiving warfarin therapy. Pharmacotherapy. 2011;31(6):591-7.

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Published

2018-01-23

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Section

Original Research Articles