Herbal conjugation for increased binding of zinc pyrithione on hair: new treatment approach


  • Amruthavalli G. V. R&D, Dr. JRK’s Research and Pharmaceuticals Pvt Ltd, Chennai, Tamil Nadu
  • Satarupa Mukherjee Department of Microbiology, Dr. JRK’s Research and Pharmaceuticals Pvt Ltd, Chennai, Tamil Nadu
  • Gayathri Rajagopal Dr. JRK’s Research and Pharmaceuticals Pvt Ltd, Chennai, Tamil Nadu




Dandruff, Zinc pyrithione, Hair perforation test, Fungal colonization, Herbal, Fungal infections, Anti-dandruff shampoo


Background: Fungal infections of scalp and hair are common now-a-days and emerging. There are various medicaments for scalp mycosis. Shampoos attained importance due ease of use. But they underperform or perform poorly due to the likely short contact time as most of them are wash off products. Selective binding of the anti-fungal agents over hair in short contact time alone can address the problem of scalp mycosis.

Methods: AAS was done to establish the adhesion of anti-fungal agents over hair and the rate of fungal colonization over hair and the extent of hair perforation were used to establish the effect of herbal conjugation in providing anti-fungal activity and blocking the parasitic conversion of fungi.

Results: Zinc adhesion was significant in Verdura anti scaling scalp shampoo and zinc pyrithione treated and no colonization and perforation was observed in Verdura anti scaling scalp shampoo and zinc pyrithione treated hair samples.

Conclusions: Present study deals with the importance of herbal conjugation technology in enhancing the targeted delivery of zinc pyrithione over hair. The present technology is important for achieving greater anti-fungal benefits from wide range of toiletry preparations due to their short contact time. 


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Original Research Articles