Prevalence of metabolic syndrome in psoriasis vulgaris: a cross sectional study from a tertiary care hospital of South-East Rajasthan
DOI:
https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20162832Keywords:
Psoriasis, Metabolic syndrome, South-east RajasthanAbstract
Background: Psoriasis, a common skin disorder is now considered as systemic inflammatory disease. Its chronic inflammatory state is thought to predispose patients to metabolic syndrome (MetS), which is a significant predictor of cardiovascular events. The objective of the study is to investigate the prevalence of metabolic syndrome in psoriatic patients with only cutaneous involvement and to evaluate the correlation between presence of MetS and psoriasis severity
Methods: We performed hospital based, cross-sectional study on 100 adult patients with psoriasis vulgaris and equi-numbered age and sex matched controls. MetS was diagnosed by revised National Cholesterol Education Program’s Adult Panel III criteria.
Results: A higher prevalence of metabolic syndrome was found in psoriasis patients as compared to controls [28 (28%) vs 9 (9%), P value=0.0005].Impaired fasting glucose level, hypertension, hypertriglyceridemia and abdominal obesity were more prevalent in psoriasis group. No statistically significant difference was found between prevalence of low levels of HDL and presence of metabolic syndrome. Presence of metabolic syndrome was not associated with severity and duration of psoriasis. Female patients with psoriasis were more frequently having metabolic syndrome.
Conclusions: Prevalence of metabolic syndrome is higher in patients with psoriasis irrespective of its duration and severity. This stresses on the need of regular evaluation for the presence of MetS or any of its components in psoriasis patients so as to allow early detection and management.Metrics
References
Krueger G, Ellis CN. Psoriasis – recent advances in understanding its pathogenesis and treatment. J Am Acad Dermatol. 2005;53:94–100.
Davidovici BB, Sattar N, Prinz JC, Puig L, Emery P, Barker JN, et al. Psoriasis and systemic inflammatory diseases: Potential mechanistic links between skin disease and co-morbid conditions. J Invest Dermatol. 2010;130:1785–96.
Gelfand JM, Neimann AN, Shin DB, Wang X, Margolis DJ, Troxel AB. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006;296:1735-41.
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Ecke RH, Franklin BA, et al. Diagnosis and Management of the Metabolic Syndrome. Circulation. 2005;112:2735-52.
Kumar R, Sharma A, Dogra S. Prevalence and clinical patterns of psoriatic arthritis in Indian patients with psoriasis. Indian J Dermatol Venereol Leprol. 2014;80:15-23.
Padhi T, Garima. Metabolic syndrome and skin: Psoriasis and beyond. Indian J Dermatol. 2013;58:299–305.
Gisondi P, Tessari G, Conti A, Piaserico S, Schianchi S, Peserico A, et al. Prevalence of metabolic syndrome in patients with psoriasis: A hospital based case control study. Br J Dermatol. 2007;157:68 73.
Nisa N, Qazi MA. Prevalence of metabolic syndrome in patients with psoriasis. Indian J Dermatol Venereol Leprol. 2010;76:662-5.
Karoli R, Fatima J, Shukla V, Dhillon KS, Khanduri S, Maini S, et al. A study of cardio-metabolic risk profile in patients with psoriasis. The Journal of the Association of Physicians of India. 2013;61:798-803.
Lakshmi S, Nath AK, Udayashankar C. Metabolic syndrome in patients with psoriasis: A comparative study. Indian dermatol online J. 2014;5(2):132-7.
Madanagobalane S, Anandan S. Prevalence of Metabolic Syndrome In South Indian Patients with Psoriasis Vulgaris and the Relation Between Disease Severity and Metabolic Syndrome: A Hospital-Based Case-Control Study. Indian J of dermatol. 2012;57(5):353-7.
Ali N, Kuruvila M, Unnikrishnan B. Psoriasis and metabolic syndrome: A case control study. Indian journal of dermatology, venereology and leprology. 2014;80(3):255-7.
Sharma A, Gopalakrishnan D, Kumar R, Vijayvergiya R, Dogra S. Metabolic syndrome in psoriatic arthritis patients: A cross‐sectional study. International journal of rheumatic diseases. 2013;16:667-73.
Zindancı I, Albayrak O, Kavala M, Kocaturk E, Can B, Sudogan S, et al. Prevalence of metabolic syndrome in patients with psoriasis. [cited 2012 Aug 10]; Sceintific World Journal [Internet] 2012 Apr; 2012:312463. Available from: http://www. hindawi.com/journals/tswj/2012/32146.
Khunger N, Gupta D, Ramesh V. Is psoriasis a new cutaneous marker for metabolic syndrome? A study in Indian patients. Indian journal of dermatology. 2013;58:313.
Mebazaa A, El Asmi M, Zidi W, Zayani Y, CheikhRouhou R, El Ounifi S, et al. Metabolic syndrome in Tunisian psoriatic patients: Prevalence and determinants. J Eur Acad Dermatol Venereol. 2011;25:705‑9.
Choi WJ, Park EJ, Kwon IH, Kim KH, Kim KJ. Association between psoriasis and cardiovascular risk factors in Korean patients. Ann Dermatol. 2010;22:300-6.
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