Assessing disease severity by hsCRP as a biochemical marker for psoriasis


  • Kriti Jain Department of Dermatology, Subharti Medical College, Meerut, Uttar Pradesh, India
  • Arvind Krishna Department of Dermatology, Subharti Medical College, Meerut, Uttar Pradesh, India
  • B. S. Rathore Department of Dermatology, Subharti Medical College, Meerut, Uttar Pradesh, India



Psoriasis, PASI, BSA. High sensitivity CRP


Background: For a complex chronic disease like psoriasis, having a biomarker to objectively assess the clinical severity can be very helpful in disease management.

Methods: In a hospital based prospective study, 70 patients of psoriasis diagnosed clinically, were studied. The extent of disease severity was assessed using PASI and BSA and patients were grouped into having mild, moderate and severe disease using these scores. Serum high sensitivity C-reactive protein (hsCRP) levels were then estimated for each group.

Results: Of the 70 psoriasis cases enrolled, 46 patients were male and 24 females. Patients with early onset psoriasis were associated with higher values of hsCRP than those with late onset (r=-0.063; p=0.012). A positive correlation was seen between the PASI score and hsCRP levels (r=0.891; p≤0.001). On comparing mean PASI and mean hsCRP in severity groups (mild, moderate and severe), hsCRP was higher in the group with maximum severity (p≤0.001).

Conclusions: A negative correlation between the age of onset and hsCRP implies that, earlier the age of onset, higher is the value of hsCRP. Our study shows a positive correlation between the body surface area and PASI score both of which varied linearly with hsCRP values. The findings also suggest that patients with severe psoriasis have higher mean serum hsCRP levels than patients with mild psoriasiss.We proposed hsCRP as a useful marker of psoriasis severity that could be used to monitor psoriasis and, together with PASI, as a global index of disease severity.


Author Biography

Kriti Jain, Department of Dermatology, Subharti Medical College, Meerut, Uttar Pradesh, India

department of Dermatology

Subharti Medical College


Spah F. Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. British J Dermatol. 2008;159(2):10-7.

Fredriksson T, Pettersson U. Severe psoriasis—oral therapy with a new retinoid. Dermatologica. 1978;157:238–44.

Pepys MB, Hirschfield GM. C-reative protein: a critical update. J Clin Invest. 2003;111:1805–12.

Paller D, Petrou I. Pediatric psoriasis: C-reactive protein levels associated with disease severity. J Invest Dermatol. 2009;102:219–27.

Prodanovich S, Kirsner RS, K revetez JD Association of Psoriasis with coronery artery disease, cerebrovascular & peripheral vascular disease & mortality. Arch Dermatol. 2009;20(470):197413.

Rocha-Pereira P, Santos-Silva A, Rebelo I, Figueiredo, Quintanilha A, Teixeira F. The Inflammatory Response in Mild and in Severe Psoriasis. British J Dermatol. 2004;150(5):917-28.

Christopher Ritchlin T, Abrar A, Kurt de Vlam Q, Pitzalis C, Helliwell P. Biomarkers in Psoriasis and Psoriatic Arthritis: GRAPPA. J Rheumatol. 2010;37(2):462-7.

Long CC, Finlay AY, Averill RW: The rule of hand: 4handareas=2FTU=1g. Arch Dermatol. 1992;128:1129–30.

He Z, Lu C, Ou A, Fang J, Wang D, Deng J, et al. Reliability and validity of the Chinese version of the Psoriasis Disability Index (PDI) in Chinese patients with psoriasis. Health Qual Life Outcomes. 2012;10:37

Jagannath S. Study of High Sensitive C Reactive Protein and Lipid Profile in Psoriasis. Int J Clinical Biochem Res. 2014;1(1):1-6.

Keerthana B, Kumar T. Serum biomarkers for diagnosis and assessment of severity in psoriasis. Int J Biomed Adv Res. 2016;7(1):17.

Agravatt AM, Sirajwala HB. A Study of serum hsCRP levels to assess severity in patients with Psoriasis. Int J Biomed Advance Res. 2013;4(7):460-6.






Original Research Articles