Efficacy and tolerability of a multi-ingredient nutraceutical on facial skin ageing parameters and self-reported wellbeing: a prospective, open-label and single-arm pilot study

Shalini Thukral; Shikha Singh; Anjali Salvi

doi:10.18203/issn.2455-4529.IntJResDermatol20263696

Authors

Shalini Thukral Svista India Private Limited, Bengaluru, Karnataka, India
Shikha Singh Fresenius Kabi Oncology Limited, Gurugram, India
Anjali Salvi C.L.A.I.M.S. Private Limited, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20263696

Keywords:

Skin ageing, Nutraceutical, Nutricosmetics, Skin hydration, Healthy ageing

Abstract

Background: Skin ageing involves interconnected changes in extracellular matrix integrity, hydration, oxidative stress and cellular resilience. This study evaluated the efficacy and tolerability of RESET by IQ HEALTH™, a multi-ingredient oral nutraceutical, in adults with visible facial skin ageing.

Methods: This prospective, open-label, single-arm clinical study enrolled healthy adults aged 35-55 years with facial skin ageing. Participants consumed one sachet daily for 60 days. Facial firmness (Cutometer R0), elasticity (Cutometer R7), and hydration [MoistureMeter SC (MMSC)] were assessed at baseline, day 30, and day 60. Participant-reported skin and wellness outcomes and tolerability were assessed descriptively.

Results: Thirty-four participants-initiated supplementation and 33 completed the study. At day 60, firmness improved by 38.9%, elasticity by 8.9%, and hydration by 19.2% from baseline (all p<0.001). Significant changes were observed at day 30. At day 60, 84.9% reported firmer/tighter facial skin, 81.8% reported a younger appearance, and 90.9% reported improved moisturization and hydration. Exploratory improvements were also reported in energy, joint comfort, sleep quality, fatigue, relaxation, and muscle soreness. The product was generally well tolerated; gastrointestinal symptoms were mild and infrequent, with no serious adverse events or treatment-related discontinuations.

Conclusions: Daily supplementation with RESET by IQ HEALTH™ for 60 days was associated with improvements in facial skin firmness, elasticity, and hydration, together with favourable participant-reported skin and wellness outcomes. These findings are preliminary given the single-arm, open-label design and small sample size and require confirmation in randomized, placebo-controlled studies.

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References

Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol. 2012;4(3):308-19. DOI: https://doi.org/10.4161/derm.22804

Shin JW, Kwon SH, Choi JY, Na JI, Huh CH, Choi HR, et al. Molecular Mechanisms of Dermal Aging and Antiaging Approaches. Int J Mol Sci. 2019;20(9):2126. DOI: https://doi.org/10.3390/ijms20092126

Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: a key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253-8. DOI: https://doi.org/10.4161/derm.21923

Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 1997;337(20):1419-28. DOI: https://doi.org/10.1056/NEJM199711133372003

Kammeyer A, Luiten RM. Oxidation events and skin aging. Ageing Res Rev. 2015;21:16-29. DOI: https://doi.org/10.1016/j.arr.2015.01.001

Fligiel SE, Varani J, Datta SC, Kang S, Fisher GJ, Voorhees JJ. Collagen degradation in aged/photodamaged skin in vivo and after exposure to matrix metalloproteinase-1 in vitro. J Invest Dermatol. 2003;120(5):842-8. DOI: https://doi.org/10.1046/j.1523-1747.2003.12148.x

Woodby B, Penta K, Pecorelli A, Lila MA, Valacchi G. Skin Health from the Inside Out. Annu Rev Food Sci Technol. 2020;11:235-54. DOI: https://doi.org/10.1146/annurev-food-032519-051722

Hsu TF, Su ZR, Hsieh YH, Wang MF, Oe M, Matsuoka R, et al. Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study. Nutrients. 2021;13(7):2220. DOI: https://doi.org/10.3390/nu13072220

Gueniche A, Castiel-Higounenc I. Efficacy of glucosamine sulphate in skin ageing: results from an ex vivo anti-ageing model and a clinical trial. Skin Pharmacol Physiol. 2017;30(1):36-41. DOI: https://doi.org/10.1159/000450832

Bissett DL. Glucosamine: an ingredient with skin and other benefits. J Cosmet Dermatol. 2006;5(4):309-15. DOI: https://doi.org/10.1111/j.1473-2165.2006.00277.x

Salo AM, Myllyharju J. Prolyl and lysyl hydroxylases in collagen synthesis. Exp Dermatol. 2021;30(1):38-49. DOI: https://doi.org/10.1111/exd.14197

Selvarajah B, Azuelos I, Platé M, Guillotin D, Forty EJ, Contento G, et al. mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis. Sci Signal. 2019;12(582):eaav3048. DOI: https://doi.org/10.1126/scisignal.aav3048

Jang YA, Kim SG. Inhibitory activity of blueberries on UVB-induced oxidative stress and matrix metalloproteinase expression in human skin fibroblasts. J Life Sci. 2019;29(12):1321-8.

Ivarsson J Jr, Pecorelli A, Lila MA, Valacchi G. Blueberry Supplementation and Skin Health. Antioxidants 2023;12:1261. DOI: https://doi.org/10.3390/antiox12061261

Halliwell B, Tang RMY, Cheah IK. Diet-Derived Antioxidants: The Special Case of Ergothioneine. Annu Rev Food Sci Technol. 2023;14:323-45. DOI: https://doi.org/10.1146/annurev-food-060822-122236

Sengupta A, Lichti UF, Carlson BA, Ryscavage AO, Gladyshev VN, Yuspa SH, et al. Selenoproteins are essential for proper keratinocyte function and skin development. PLoS One. 2010;5(8):e12249. DOI: https://doi.org/10.1371/journal.pone.0012249

Benedikt Justus Beine, Melissa Castellano, Jarlei Fiamoncini, Karsten Hiller; Taurine supplementation at the crossroads of metabolism, inflammation and aging: mechanistic and nutritional perspectives. Food Funct. 2026;17(13):5880-904. DOI: https://doi.org/10.1039/D6FO01808D

Virmani MA, Cirulli M. The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation. Int J Mol Sci. 2022;23(5):2717. DOI: https://doi.org/10.3390/ijms23052717

Chen Z. L-citrulline as a nitric oxide-modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women. Amino Acids. 2026. DOI: https://doi.org/10.1007/s00726-026-03541-1

Barbagallo M, Veronese N, Dominguez LJ, Magnesium in Aging, Health and Diseases. Nutrients. 2021;13:463. DOI: https://doi.org/10.3390/nu13020463

Arribas-López E, Zand N, Ojo O, Snowden MJ, Kochhar T. A Systematic Review of the Effect of Centella asiatica on Wound Healing. Int J Environ Res Public Health. 2022;19(6):3266. DOI: https://doi.org/10.3390/ijerph19063266

Hillier RA, Gibson R, Maruthappu T, Whelan K, Prpa EJ, Neill HR, et al. Probiotics, Prebiotics, and Synbiotics as Oral Supplements for Skin Health, Function, and Disease Throughout the Life Course: A Scoping Review. Nutr Rev. 2025;nuaf205. DOI: https://doi.org/10.1017/S0029665125100724

Kim H, Bang WY, Jeong KH, Jung YH, Yang J, Moon JS. Effects of Heat-Killed Lactobacillus acidophilus IDCC 3302 on Skin Aging Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Adults. Nutrients. 2026;18(4):596. DOI: https://doi.org/10.3390/nu18040596

Fernstrom JD, Fernstrom MH. Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. J Nutr. 2007;137(6-1):1539S-47S. DOI: https://doi.org/10.1093/jn/137.6.1539S

Segger D, Schönlau F. Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. J Dermatolog Treat. 2004;15(4):222-6. DOI: https://doi.org/10.1080/09546630410033772

Udompataikul M, Sripiroj P, Palungwachira P. An oral nutraceutical containing antioxidants, minerals and glycosaminoglycans improves skin roughness and fine wrinkles. Int J Cosmet Sci. 2009;31(6):427-35. DOI: https://doi.org/10.1111/j.1468-2494.2009.00513.x

Murad H, Tabibian MP. The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: A preliminary study. J Dermatolog Treat. 2001;12(1):47-51. DOI: https://doi.org/10.1080/095466301750163590

Di Cerbo A, Laurino C, Palmieri B, Iannitti T. A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins. J Photochem Photobiol B. 2015;144:94-103. DOI: https://doi.org/10.1016/j.jphotobiol.2014.12.025

Stephens TJ, Sigler ML, Hino PD, Moigne AL, Dispensa L. A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin. J Clin Aesthet Dermatol. 2016;9(4):25-32.

Nobile V, Dudonné S, Kern C, Roveda G, Garcia C. Antiaging, brightening, and antioxidant efficacy of fermented bilberry extract (Vaccinium myrtillus): A randomized, double-blind, placebo-controlled trial. Nutrients. 2024;16(14):2203. DOI: https://doi.org/10.3390/nu16142203

Yang Q, Li H, Zhang H, Ma L, Zhang X and Wu J. Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials. Front Med. 2025;12:1582946. DOI: https://doi.org/10.3389/fmed.2025.1582946

Czajka A, Kania EM, Genovese L, Corbo A, Merone G, Luci C, et al. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res. 2018;57:97-108. DOI: https://doi.org/10.1016/j.nutres.2018.06.001