Efficacy and tolerability of a multi-ingredient nutraceutical on facial skin ageing parameters and self-reported wellbeing: a prospective, open-label and single-arm pilot study

Shalini Thukral; Shikha Singh; Anjali Salvi

doi:10.18203/issn.2455-4529.IntJResDermatol20263696

Authors

Shalini Thukral Svista India Private Limited, Bengaluru, Karnataka, India
Shikha Singh Fresenius Kabi Oncology Limited, Gurugram, India
Anjali Salvi C.L.A.I.M.S. Private Limited, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20263696

Keywords:

Skin ageing, Nutraceutical, Nutricosmetics, Skin hydration, Healthy ageing

Abstract

Background: Skin ageing involves interconnected changes in extracellular matrix integrity, hydration, oxidative stress and cellular resilience. This study evaluated the efficacy and tolerability of RESET by IQ HEALTH™, a multi-ingredient oral nutraceutical, in adults with visible facial skin ageing.

Methods: This prospective, open-label, single-arm clinical study enrolled healthy adults aged 35-55 years with facial skin ageing. Participants consumed one sachet daily for 60 days. Facial firmness (Cutometer R0), elasticity (Cutometer R7), and hydration [MoistureMeter SC (MMSC)] were assessed at baseline, day 30, and day 60. Participant-reported skin and wellness outcomes and tolerability were assessed descriptively.

Results: Thirty-four participants-initiated supplementation and 33 completed the study. At day 60, firmness improved by 38.9%, elasticity by 8.9%, and hydration by 19.2% from baseline (all p<0.001). Significant changes were observed at day 30. At day 60, 84.9% reported firmer/tighter facial skin, 81.8% reported a younger appearance, and 90.9% reported improved moisturization and hydration. Exploratory improvements were also reported in energy, joint comfort, sleep quality, fatigue, relaxation, and muscle soreness. The product was generally well tolerated; gastrointestinal symptoms were mild and infrequent, with no serious adverse events or treatment-related discontinuations.

Conclusions: Daily supplementation with RESET by IQ HEALTH™ for 60 days was associated with improvements in facial skin firmness, elasticity, and hydration, together with favourable participant-reported skin and wellness outcomes. These findings are preliminary given the single-arm, open-label design and small sample size and require confirmation in randomized, placebo-controlled studies.

References

Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol. 2012;4(3):308-19.

Shin JW, Kwon SH, Choi JY, Na JI, Huh CH, Choi HR, et al. Molecular Mechanisms of Dermal Aging and Antiaging Approaches. Int J Mol Sci. 2019;20(9):2126.

Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: a key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253-8.

Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 1997;337(20):1419-28.

Kammeyer A, Luiten RM. Oxidation events and skin aging. Ageing Res Rev. 2015;21:16-29.

Fligiel SE, Varani J, Datta SC, Kang S, Fisher GJ, Voorhees JJ. Collagen degradation in aged/photodamaged skin in vivo and after exposure to matrix metalloproteinase-1 in vitro. J Invest Dermatol. 2003;120(5):842-8.

Woodby B, Penta K, Pecorelli A, Lila MA, Valacchi G. Skin Health from the Inside Out. Annu Rev Food Sci Technol. 2020;11:235-54.

Hsu TF, Su ZR, Hsieh YH, Wang MF, Oe M, Matsuoka R, et al. Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study. Nutrients. 2021;13(7):2220.

Gueniche A, Castiel-Higounenc I. Efficacy of glucosamine sulphate in skin ageing: results from an ex vivo anti-ageing model and a clinical trial. Skin Pharmacol Physiol. 2017;30(1):36-41.

Bissett DL. Glucosamine: an ingredient with skin and other benefits. J Cosmet Dermatol. 2006;5(4):309-15.

Salo AM, Myllyharju J. Prolyl and lysyl hydroxylases in collagen synthesis. Exp Dermatol. 2021;30(1):38-49.

Selvarajah B, Azuelos I, Platé M, Guillotin D, Forty EJ, Contento G, et al. mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis. Sci Signal. 2019;12(582):eaav3048.

Jang YA, Kim SG. Inhibitory activity of blueberries on UVB-induced oxidative stress and matrix metalloproteinase expression in human skin fibroblasts. J Life Sci. 2019;29(12):1321-8.

Ivarsson J Jr, Pecorelli A, Lila MA, Valacchi G. Blueberry Supplementation and Skin Health. Antioxidants 2023;12:1261.

Halliwell B, Tang RMY, Cheah IK. Diet-Derived Antioxidants: The Special Case of Ergothioneine. Annu Rev Food Sci Technol. 2023;14:323-45.

Sengupta A, Lichti UF, Carlson BA, Ryscavage AO, Gladyshev VN, Yuspa SH, et al. Selenoproteins are essential for proper keratinocyte function and skin development. PLoS One. 2010;5(8):e12249.

Benedikt Justus Beine, Melissa Castellano, Jarlei Fiamoncini, Karsten Hiller; Taurine supplementation at the crossroads of metabolism, inflammation and aging: mechanistic and nutritional perspectives. Food Funct. 2026;17(13):5880-904.

Virmani MA, Cirulli M. The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation. Int J Mol Sci. 2022;23(5):2717.

Chen Z. L-citrulline as a nitric oxide-modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women. Amino Acids. 2026.

Barbagallo M, Veronese N, Dominguez LJ, Magnesium in Aging, Health and Diseases. Nutrients. 2021;13:463.

Arribas-López E, Zand N, Ojo O, Snowden MJ, Kochhar T. A Systematic Review of the Effect of Centella asiatica on Wound Healing. Int J Environ Res Public Health. 2022;19(6):3266.

Hillier RA, Gibson R, Maruthappu T, Whelan K, Prpa EJ, Neill HR, et al. Probiotics, Prebiotics, and Synbiotics as Oral Supplements for Skin Health, Function, and Disease Throughout the Life Course: A Scoping Review. Nutr Rev. 2025;nuaf205.

Kim H, Bang WY, Jeong KH, Jung YH, Yang J, Moon JS. Effects of Heat-Killed Lactobacillus acidophilus IDCC 3302 on Skin Aging Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Adults. Nutrients. 2026;18(4):596.

Fernstrom JD, Fernstrom MH. Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. J Nutr. 2007;137(6-1):1539S-47S.

Segger D, Schönlau F. Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. J Dermatolog Treat. 2004;15(4):222-6.

Udompataikul M, Sripiroj P, Palungwachira P. An oral nutraceutical containing antioxidants, minerals and glycosaminoglycans improves skin roughness and fine wrinkles. Int J Cosmet Sci. 2009;31(6):427-35.

Murad H, Tabibian MP. The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: A preliminary study. J Dermatolog Treat. 2001;12(1):47-51.

Di Cerbo A, Laurino C, Palmieri B, Iannitti T. A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins. J Photochem Photobiol B. 2015;144:94-103.

Stephens TJ, Sigler ML, Hino PD, Moigne AL, Dispensa L. A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin. J Clin Aesthet Dermatol. 2016;9(4):25-32.

Nobile V, Dudonné S, Kern C, Roveda G, Garcia C. Antiaging, brightening, and antioxidant efficacy of fermented bilberry extract (Vaccinium myrtillus): A randomized, double-blind, placebo-controlled trial. Nutrients. 2024;16(14):2203.

Yang Q, Li H, Zhang H, Ma L, Zhang X and Wu J. Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials. Front Med. 2025;12:1582946.

Czajka A, Kania EM, Genovese L, Corbo A, Merone G, Luci C, et al. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res. 2018;57:97-108.