SB-NASHA: a review on scientific differentiation and skin quality enhancement

Chiranjiv Chhabra; Chaithra Shenoy; Anirban Ghosh; Meghna Mour; Dyotona Sen; Sameer Jadhwar

doi:10.18203/issn.2455-4529.IntJResDermatol20263752

Authors

Chiranjiv Chhabra Skin Alive Clinics, Delhi, India, M.P, India
Chaithra Shenoy CUTIS Academy of Cutaneous Sciences, Bangalore, India
Anirban Ghosh Anirvana Clinic, Kolkata, India
Meghna Mour SKUCCII Supercliniq, Mumbai, India
Dyotona Sen Department of Medical Affairs, Galderma India
Sameer Jadhwar Department of Medical Affairs, Galderma India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20263752

Keywords:

Aging, ECM, Fillers, NASHA

Abstract

Skin aging is a multifactorial process driven by intrinsic biological changes and extrinsic environmental factors, leading to reduced hydration, collagen degradation, loss of elasticity, and the development of fine lines and wrinkles. Hyaluronic acid (HA), due to its superior hydrating, viscoelastic, and biocompatible properties, plays a central role in minimally invasive skin rejuvenation strategies. HA-based skin booster non-animal stabilized hyaluronic acid (SB-NASHA) 20 mg Skinboosters™ represent a novel therapeutic approach that improves skin quality through intradermal microinjections, restoring hydration, stimulating fibroblast activity, and promoting extracellular matrix remodelling. A structured literature review was conducted using PubMed, Scopus, Web of Science, and Google Scholar to identify studies published between 2007 and 2025 evaluating the mechanisms, clinical efficacy, and safety of SB-NASHA 20 mg hyaluronic acid skinboosters for skin rejuvenation. Eligible studies included clinical trials and observational studies reporting outcomes related to skin hydration, elasticity, texture, or patient satisfaction. Relevant data were qualitatively synthesized. Additionally, their adjunctive use with aesthetic procedures such as botulinum toxin injections or laser resurfacing has shown synergistic effects. With a favourable safety profile and minimal downtime, SB-NASHA provides healthcare professionals with an effective, evidence-based option for managing early and advanced signs of skin aging. This review offers consolidated, practice-oriented insights and expert panel perspectives to support the optimal clinical use of SB-NASHA 20 mg in aesthetic dermatology.

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