DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20173138

Clinico-epidemiological profile of condylomata acuminata with special emphasis on HPV typing

A. Sarin, V. G. Binesh, Betsy Ambooken, S. Suprakasan

Abstract


Background: Condylomata acuminata (CA) or genital wart is a sexually transmitted infection (STI) caused by human papilloma virus (HPV). As there was little information about the HPV types commonly causing CA in our state, we decided to study the clinico-epidemiological profile of CA with special emphasis on HPV typing.

Methods: We did HPV typing in 25 clinically diagnosed cases of CA. The biopsied specimens were sent for HPV typing using Polymerase chain reaction (PCR) and those with high risk HPV types were histologically analyzed for any dysplastic change. We also evaluated for other STIs which can coexist with CA.

Results: Out of the 25 cases, 18 (72%) were males and 7 (28%) females. Majority of our patients belonged to 21-40 year age group (64%). Clinical types of CA were the classical fleshy exuberant type in 22 patients (88%), flat type in 2 (8%) and keratotic type in 1 (4%). HPV positivity was obtained in 21 (84%). The most common type was HPV 6 in 10 cases (40%) and HPV 11 in 8 (32%) patients. HPV 16 alone was isolated in 1 (4%) case. HPV types 6 and 16 and 11 & 18 were isolated in one case each. Dysplastic changes were observed in two cases with HPV 16 and 18. VDRL and TPHA positivity was found in 2 (8%) males and HBsAg positivity was seen in 1 (4%) male patient.

Conclusions: This study highlights the importance of HPV typing for identifying the high risk types and to assess the efficacy of HPV vaccines.


Keywords


Condylomata acuminata, HPV types, PCR, Dysplasia

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References


Lynde C, Vender R, Bourcier M, Bhatia N. Clinical features of external genital warts. J Cutan Med Surg. 2013;2:S55-60.

Chang L, Ci P, Shi J, Zhai K, Feng X, Colombara D et al. Distribution of genital wart human papillomavirus genotypes in China: a multi-center study. Med Virol. 2013;85:1765-74.

Kinghorn GR. Genital warts: incidence of associated genital infections. Br J Dermatol. 1978;99:405.

Koutsky L. Epidemiology of genital warts in Engl and and Wales: 1971-1994. Genitourin Med. 1997;73:365-7.

Kemp EA. Human papilloma virus prevalence in pregnancy. Obstet Gynecol. 1992;79:649.

Peng TC, Searle CP 3rd, Shah KV, Repke JT, Johnson TR. Prevalence of human papilloma virus infections in term pregnancy. Am J Perinatol. 1990;7:189.

Maymon R, Shulman A, Maymon B, Bekerman A, Werchow M, Faktor Joseph H, et al. Penile condylomata: a gynaecological epidemic disease: a review of the current approach and management aspects. Obstet Gynecol Sur. 1994;49(11):790.

Hippeläinen M, Syrjänen S, Hippeläinen M, Koskela H, Pulkkinen J, Saarikoski S, et al. Prevalence and risk factors of genital HPV infections in healthy males. A study of Finnish conscripts. Sex Transm Dis. 1993;20:321-8.

Tachezy R, Smahelova J, Salakova M, Arbyn M, Rob L, Skapa P, et al. Human Papillomavirus Genotype Distribution in Czech Women and Men with Diseases Etiologically Linked to HPV. PLoS One. 2011;6(7):e21913.

Zhong TY, Zhou JC, Hu R, Fan XN, Xie XY, Liu ZX, et al. Prevalence of human papillomavirus infection among 71,435 women in Jiangxi Province, China. J Infect Public Health. 2017;2:1876.

Aubin F, Prétet JL, Jacquard AC, Saunier M, Carcopino X, Jaroud F, et al. Human papillomavirus genotype distribution in external acuminata condylomata: a large French national study. Clin Infect Dis. 2008;47(5):610-5.

Wikström A, Vassilaki I, Hedblad MA, Syrjänen S. The Spectrum of Genital Human Papillomavirus Infection Among Men Attending a Swedish Sexually-transmitted Infections Clinic: Human Papillomavirus Typing and Clinical Presentation of Histopathologically Benign Lesions. Acta Derm Venereol. 2013;93:223–7.

Sturegård E, Johansson H, Ekström J, Hansson BG, Johnsson A, Gustafsson E, et al. Human papillomavirus typing in reporting of condyloma. Sex Transm Dis. 2013;40(2):123-9.

Baydar DE, Kulac I, Ozagari A, Guler Tezel G. Occurrence of dysplasia and human papilloma virus typing in penile condylomas. Urology. 2013;81(1):211-5.

Loumpardia P, Bourmpos K, Loumpardias GA, Kalampoki V, Valasoulis G, Valari O, et al. Epidemiological, clinical, and virological characteristics of women with genital warts in Greece. Clin Exp Obstet Gynecol. 2015;42(2):188-90.

Ünal E, Gönül M, Çakmak S, Iyidal YA, Kılıç A, Gül Ü. Serological test results of sexually transmitted diseases in patients with condyloma acuminata. Advances Dermatol Allergol/Postȩpy Dermatol I Alergol. 2015;32(4):286–9.

Nishijima T, Nagata N, Watanabe K, Sekine K, Tanaka S, Kishida Y, et al. HIV-1 infection, but not syphilis or HBV infection, is a strong risk factor for anorectal condyloma in Asian population: A prospective colonoscopy screening study. Int J Infect Dis. 2015;37:70–6.