Anti-dandruff efficacy of ayurvedic scalp leave-on treatment: a double-blinded, randomized placebo-controlled clinical study

Machavolu Soubhagya Lakshmi Madhavi; Ravi Kant Shukla; Susmita Gudulkar; Saurabh Mathur; Supriya Punyani

doi:10.18203/issn.2455-4529.IntJResDermatol20252548

Authors

Machavolu Soubhagya Lakshmi Madhavi Research and Development, Hindustan Unilever Ltd., Mumbai, Maharashtra, India
Ravi Kant Shukla Research and Development, Hindustan Unilever Ltd., Mumbai, Maharashtra, India
Susmita Gudulkar Research and Development, Hindustan Unilever Ltd., Mumbai, Maharashtra, India
Saurabh Mathur Research and Development, Hindustan Unilever Ltd., Mumbai, Maharashtra, India
Supriya Punyani Research and Development, Hindustan Unilever Ltd., Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20252548

Keywords:

Anti-dandruff, Ayurvedic, Indulekha Svetakutaja

Abstract

Background: This study aimed to evaluate the efficacy and safety of ayurvedic leave on treatment product in the management of dandruff through a randomized, double-blind, placebo-controlled study.

Methods: A total of 112 subjects with clinically diagnosed moderate dandruff were randomly assigned to group A (ayurvedic leave-on treatment group) and group B (placebo group), where 110 subjects completed the study. The treatment phase was for 4 weeks, followed by a regression phase of 1 week. Subjects applied the allotted product on their scalp and massaged. It’s a leave on product so the subjects were asked not to wash off.

Results: After 4 weeks of treatment, test product group A demonstrated a significantly greater reduction in dandruff severity compared to group B (p<0.05). The adherent dandruff scores in group A showed a significant reduction of 17.56 units/41% while in group B, it was noted to be 29.4%/12.4 units. Additionally, 100% of subjects in group A reported a subjective perception improvement in symptoms of dandruff within 2 weeks when compared to group B which is only by 81%.

Conclusions: Indulekha Svetakutaja scalp leave-on treatment is a safe and highly effective solution designed to combat dandruff while simultaneously enhancing the overall health of the scalp and hair.

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References

Harding CR, Moore AE, Rogers SJ, Meldrum H, Scott AE, McGlone FP. Dandruff: a condition characterized by decreased levels of intercellular lipids in scalp stratum corneum and impaired barrier function. Arch Dermatol Res. 2002;294(5):221-30. DOI: https://doi.org/10.1007/s00403-002-0323-1

Misery L, Rahhali N, Duhamel A, Taieb C. Epidemiology of dandruff, scalp pruritus and associated symptoms. Acta Dermato-Venereologica. 2013;93(1):80-1. DOI: https://doi.org/10.2340/00015555-1315

Schwartz JR, Messenger AG, Tosti A, Todd G, Hordinsky M, Hay RJ, et al. A comprehensive pathophysiology of dandruff and seborrheic dermatitis-towards a more precise definition of scalp health. Acta Derm Venereol. 2013;93(2):131-7. DOI: https://doi.org/10.2340/00015555-1382

Cheng Y, Cong J, Xu J, Tang L, Zhou Z, Yang X, et al. Research Progress on the Exacerbation of Lipid Metabolism by Malassezia and Its Impact on the Skin Barrier Function. Cosmetics. 2025;12(2):67. DOI: https://doi.org/10.3390/cosmetics12020067

Schwartz JR, DeAngelis YM, Dawson TL. Dandruff and seborrheic dermatitis: a head scratcher. Pract Modern Hair Sci. 2012;1:389-13.

Davis MG, Piliang MP, Bergfeld WF, Caterino TL, Fisher BK, Sacha JP, et al. Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8‐week randomized, double‐blind, placebo‐controlled clinical study. Int J Cosmet Sci. 2021;43:26-33. DOI: https://doi.org/10.1111/ics.12737

Schwartz JR, Henry JP, Kerr KM, Mizoguchi H, Li L. The role of oxidative damage in poor scalp health: ramifications to causality and associated hair growth. Int J Cosmet Sci. 2015;37:9-15. DOI: https://doi.org/10.1111/ics.12289

Nakagawa K, Shibata A, Maruko T, Sookwong P, Tsuduki T, Kawakami K, et al. γ-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes. Lipids. 2010;45:833-41. DOI: https://doi.org/10.1007/s11745-010-3458-4

Balkrishna A, Ngpoore NK, Jonwal H, Lochab S, Varshney A. Anti-furfurative comparison of Kesh Kanti-Herbal Shampoos and synthetic shampoos against Malassezia furfur for dandruff management. AMB Express. 2025;13;15(1):8. DOI: https://doi.org/10.1186/s13568-024-01818-w

Park M, Cho YJ, Lee YW, Jung WH. Understanding the mechanism of action of the anti-dandruff agent zinc pyrithione against Malassezia restricta. Sci Rep. 2018;8(1):12086. DOI: https://doi.org/10.1038/s41598-018-30588-2

Reeder NL, Xu J, Youngquist RS, Schwartz JR, Rust RC, Saunders CW. The antifungal mechanism of action of zinc pyrithione. Br J Dermatol. 2011;165(s2):9-12. DOI: https://doi.org/10.1111/j.1365-2133.2011.10571.x

Panchaxarimath M, Kadlimatti SM. A comparative clinical study to evaluate the efficacy of Malatyadi Taila Shiro Abhyanga over Dhurdhuradi Taila Shiro Abhyanga in the management of Darunaka (Dandruff). J Ayurved Integr Med Sci. 2023;28;8(6):07-12. DOI: https://doi.org/10.21760/jaims.8.6.2

Park M, Park S, Jung WH. Skin commensal fungus Malassezia and its lipases. J Microbiol Biotechnol. 2021;31(5):637. DOI: https://doi.org/10.4014/jmb.2012.12048

Kerr K, Schwartz JR, Filloon T, Fieno A, Wehmeyer K, Szepietowski JC, et al. Scalp stratum corneum histamine levels: novel sampling method reveals association with itch resolution in dandruff/seborrhoeic dermatitis treatment. Acta dermato-venereologica. 2011;91(4):404-8. DOI: https://doi.org/10.2340/00015555-1073

Jourdain R, Moga A, Vingler P, El Rawadi C, Pouradier F, Souverain L, et al. Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in dandruff condition. Arch Dermatol Res. 2016;308(3):153-63. DOI: https://doi.org/10.1007/s00403-016-1623-1

Trüeb RM, Henry JP, Davis MG, Schwartz JR. Scalp condition impacts hair growth and retention via oxidative stress. Int J Trichol. 2018;10(6):262-70. DOI: https://doi.org/10.4103/ijt.ijt_57_18

Iwai I, Hirao T. Protein carbonyls damage the water-holding capacity of the stratum corneum. Skin Pharmacol Physiol. 2008;21(5):269-73. DOI: https://doi.org/10.1159/000148042

Yoon JS, Shim J, Lim JM, Park SG. Biophysical characteristics of dandruff‐affected scalp categorized on the basis of sebum levels. J Cosmet Dermatol. 2021;3:1002-8. DOI: https://doi.org/10.1111/jocd.13626

Ge L, Liu Z, Xu S, Li C, Jin M, Luo Y, et al. A Cohort Clinical Study on the Efficacy of Topical Salicylic Acid/Piroctone Olamine Dandruff Pre‐Gel and Cleanser in Improving Symptoms of Moderate to Severe Seborrheic Dermatitis of the Scalp. J Cosmet Dermatol. 2025;(1):e16742. DOI: https://doi.org/10.1111/jocd.16742

Narshana M, Ravikumar P. An overview of dandruff and novel formulations as a treatment strategy. Int J Pharm Sci Res. 2018;1;9(2):417-31.

Srivastava R. A review on phytochemical, pharmacological, and pharmacognostical profile of Wrightia tinctoria: Adulterant of kurchi. Pharmacognosy Rev. 2014;15:36. DOI: https://doi.org/10.4103/0973-7847.125528

Khyade MS, Vaikos NP. Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile. J Coastal Life Med. 2014;2(10):826-40.

Vijayakumar R, Muthukumar C, Kumar T, Saravanamuthu R. Characterization of Malassezia furfur and its control by using plant extracts. Indian J Dermatol. 2006;51(2):145-8. DOI: https://doi.org/10.4103/0019-5154.26942

Jose B, Jesy EJ, Nedumpara RJ. Evaluation of the DPPH free radical scavenging activity of Wrightia tinctoria R. Br. leaf, bark and seed extracts. World J Pharm Res. 2014;3(3):5041-8.

Kumari S, Khurana S. Cosmeceuticals: Current trends and market preparations. IOSR J Pharm Biol Sci. 2013;8:45-8. DOI: https://doi.org/10.9790/3008-0834548

Jain A, Garg N. Therapeutic and Medicinal uses of Amalaki: A Review. World J Pharm Res. 2017;6(02):512-24.

Nair RM, Hameed AS. A critical review on Vasaguduchyadi Kwatha. Kerala J Ayurveda. 2024;4;3(1). DOI: https://doi.org/10.55718/kja.219

Hassan SM, Mughal SS, Aslam AS, Mushtaq MA, Munir MU, Pervez SU, et al. Emblica officinalis (Amla): A prospective review on distinctive properties and therapeutic applications of Amla. Biomed. Nurs. 2020;6:22-30.

Pingili M, Vanga S, Raparla R, Raparla RK. Antifungal activity of plant extracts against dandruff causing organism Malassezia furfur. Int J Bioassays. 2016;5(11):5047-9. DOI: https://doi.org/10.21746/ijbio.2016.11.0010

Bhat PM, Umale H, Lahankar M. Amalaki: A review on functional and pharmacological properties. J Pharmacognosy Phytochemistry. 2019;8(3):4378-82.

Vyjayanthi G, Kulkarni C, Abraham A, Kolhapure SA. Evaluation of anti-dandruff activity and safety of polyherbal hair oil: An open pilot clinical trial. The Antiseptic. 2004;101(9):368-72.

Shukla RK, Punyani S, Gudulkar S, Sachdev M, Kumari R, Sachdev A, et al. Assessment of the efficacy and safety of Indulekha Svetakutaja hair oil in management of dandruff: a randomized, double-blind, placebo-controlled study. Int J Res Dermatol. 2024;10:254-60. DOI: https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20242358

Gavle KP, Ghotankar AM. A Therapeutic Review of Medicinal Potential of Nimba (Azadirachta Indica) In Treatment of Skin Diseases. Aayushi Int Interdisciplin Res J. 2019;6:19-25.

Mishra I, Kumar Ph. Analytical study of nimbadi taila-an ayurvedic formulation. World J Pharm Res. 2022;11(2):2430-6.

Umber M, Sultana R, Ijaz T, Aala A. Leaf extract of Azadirachta indica (neem) as herbal cure of dandruff. IJCBS. 2020;17:116-8.

Dani PB, Ghorpade VK. Effect of Neem Leaf Paste Application on Dandruff. Cureus. 2025;16;17(3). DOI: https://doi.org/10.7759/cureus.80685

Hashem MM, Attia D, Hashem YA, Hendy MS, AbdelBasset S, Adel F, et al. Rosemary and neem: an insight into their combined anti-dandruff and anti-hair loss efficacy. Sci Rep. 2024;14(1):7780. DOI: https://doi.org/10.1038/s41598-024-57838-w

Patil Trupti K, Gadekar SS. To study the antidandruff activity of rosemary oil, basil oil, coleus oil over selenium sulfide. J Pharm Biosci. 2018;6(2):36-9. DOI: https://doi.org/10.31555/jpbs/2018/6/2/36-39

Rašković A, Milanović I, Pavlović N, Ćebović T, Vukmirović S, Mikov M. Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential. BMC Complement Alternat Med. 2014;14:1-9. DOI: https://doi.org/10.1186/1472-6882-14-225

Khalil DY, Hassan OM. Anti-inflammatory and Antioxidant Activity of Rosemary Essential Oil. J Angiother. 2024;8(4):1-6. DOI: https://doi.org/10.25163/angiotherapy.849609