Epidermodysplasia verruciformis associated with cutaneous malignancy: a rare inherited genodermatosis in a mother and daughter

Authors

  • Anne Cinthia Ashwin Department of Dermatology, Shri Sathya Sai Medical College & Research Institute, Chennai, Tamil Nadu, India
  • Jayakar Thomas Department of Dermatology, Chettinad Hospital and Research Institute, Chennai, Tamil Nadu, India
  • Irene Thomas Department of Dermatology, Shri Sathya Sai Medical College & Research Institute, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20252072

Keywords:

Epidermodysplasia verruciformis, Cutaneous malignancies, HPV

Abstract

Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis marked by a heightened risk of developing non-melanoma skin cancers due to a unique vulnerability to specific HPV genotypes. This susceptibility is often due to mutations in the EVER-1 or EVER-2 genes located on chromosome 17q25. Individuals with EV typically present with plane warts and pityriasis versicolor-like lesions early in life, which may evolve into malignant lesions such as Bowen’s disease, squamous cell carcinoma (SCC), and basal cell carcinoma after decades of sun exposure. EV is predominantly inherited as an autosomal recessive pattern, and several reports of EV occur in siblings. However, autosomal dominant and X-linked patterns have been sporadically recorded. This report details the rare occurrence of EV in a mother and daughter, both of whom developed cutaneous malignancies in sun-exposed areas.

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References

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Published

2025-06-27

How to Cite

Ashwin, A. C., Thomas, J., & Thomas, I. (2025). Epidermodysplasia verruciformis associated with cutaneous malignancy: a rare inherited genodermatosis in a mother and daughter. International Journal of Research in Dermatology, 11(4), 327–330. https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20252072

Issue

Section

Case Reports