Serious complication associated with mesotherapy: case report of atypical cutaneous mycobacteriosis and literature analysis
DOI:
https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20252068Keywords:
Mycobacterium abscessus, Mycobacterium abscessus massiliense, Atypical mycobacteria, PCR, Mesotherapy, Aesthetic procedures, Skin infectionsAbstract
Mycobacterium abscessus is an opportunistic pathogen that is part of the fast-growing non-tuberculous mycobacteria. It is found in the environment, such as soil and water, and represents a risk of infection. In the dermatological field, mesotherapy is used to treat various skin conditions and various medications are used. It is also used in aesthetics, but hygiene and safety standards are often not followed, which can cause complications such as infections. Skin lesions may be the first or only sign of infection. Its diagnosis is based on clinical criteria and the response to treatment. Treatment is not well established and it shows resistance to medications. This article reviews the classification, epidemiology, etiopathogenesis, transmission route, diagnostic methods, clinical presentations, histology and current therapeutic options of this group of mycobacteria.
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References
Canzona F, Mammucari M, Tuzi A, Maggiori E, Grosso MG, Antonaci L, et al. Intradermal Therapy (mesotherapy) in Dermatology. J Dermatol Skin Sci. 2020;2(1):22-5.
Schcolnik-Cabrera A, Vega-Memije E, Hernández-Castro R, Arenas R, Fernández-Martínez R. El costo de la belleza: Comunicación de seis casos clínicos con infección por micobacterias atípicas secundario a inyecciones intradérmicas y reacción a un dermoimplante de origen desconocido. Rev Chilena Infectol. 2019;36(6):778-83. DOI: https://doi.org/10.4067/S0716-10182019000600778
García-Martos P, García-Agudo L. Infecciones por micobacterias de crecimiento rápido. Enferm Infecc Microbiol Clin. 2012;30;192-200.
Mougari F, Guglielmetti L, Raskine L, Sermet-Gaudelus I, Veziris N, Cambau E. Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. Expert Rev Anti Infect Ther. 2016;(12):1139-54.
Wentworth AB, Drage LA, Wengenack NL, Wilson JW, Lohse CM. Increased incidence of cutaneous nontuberculous mycobacterial infection, 1980 to 2009: A population-based study. Mayo Clin Proc. 2013;88(1):38-45.
Contla-Martínez II, Vega-Memije ME, Arenas-Guzmán R, Boeta-Ángeles L. Micobacteriosis no tuberculosa por Mycobacterium abscessus secundaria a rasguño de gato. Dermatología Rev Mex. 2020;64(4):411-7.
Ramírez A, Araque M. Patógenos emergentes multirresistentes: complejo Mycobacterium abscessus Ana Ramírez, María Araque. Avances Biomed. 2017;6(3):203-15.
Rodríguez-Cerdeira C, Hernández-Castro R, Sánchez-Cárdenas CD, Arenas R, Meza-Robles A, Toussaint-Caire S, et al. Atypical Mycobacteriosis Due to Mycobacterium abscessus subsp. massiliense: Our Experince. Pathogens. 2022;11(12):1399. DOI: https://doi.org/10.3390/pathogens11121399
Wang X-Y, Jia Q-N, Li J. Treatment of non-tuberculosis mycobacteria skin infections. Front Pharmacol. 2023;14:1242156. DOI: https://doi.org/10.3389/fphar.2023.1242156
Estrada-Moreno BE, Sánchez-Tadeo MT, Barrios-Pérez KV, González-Angulo MN. Infección cutánea por micobacterias atípicas del complejo M. abscessus. Dematol Rev Mex. 2022;66(1):100-7.
Chung J, Ince D, Ford BA, Wanat KA. Cutaneous infections due to nontuberculosis Mycobacterium: Recognition and management. Am J Clin Dermatol. 2018;19(6):867-78. DOI: https://doi.org/10.1007/s40257-018-0382-5
Wentworth AB, Drage LA, Wengenack NL, Wilson JW, Lohse CM. Increased incidence of cutaneous nontuberculous mycobacterial infection, 1980 to 2009: A population-based study. Mayo Clin Proc. 2013;88(1):38-45. DOI: https://doi.org/10.1016/j.mayocp.2012.06.029
Jin J, Jia J, Ding XI, Chen X. Sporadic cutaneous infections due to nontuberculous mycobacteria: a retrospective study of 37 cases. Beijing Da Xue Xue Bao Yi Xue Ban. 2015;47(6):939-44.
Houben EN, Nguyen L, Pieters J. Interaction of pathogenic mycobacteria with the host immune systems. Curr Opin Microbiol. 2006;9:76-85. DOI: https://doi.org/10.1016/j.mib.2005.12.014
Garza R, Monroy F y Perea L. Micobacterias no tuberculosas: actual importancia clínica y principales factores de virulencia. 2010. Available at: http://depa.pquim.unam.mx/bacteriologia/pdfs/micobacterias.pdf. Accessed on 12 April 2025.
Cosma CL, Sherman DR, Ramakrishnan M e secret lives of the pathogenic mycobacteria. Annu Rev Microbiol 2003;57:641-76. DOI: https://doi.org/10.1146/annurev.micro.57.030502.091033
Majlessi L, Combaluzier B, Albrecht I, Garcia JE, Nouze C, Pieters J, et al. Inhibition of phagosome maturation by mycobacteria does not interfere with presentation of mycobacterial antigens by MHC molecules. J Immunol 2007;179:1825-33. DOI: https://doi.org/10.4049/jimmunol.179.3.1825
Mougari F, Guglielmetti L, Raskine L, Sermet-Gaudelus I, Veziris N, Cambau E. Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. Expert Rev Anti Infect er. 2016;14:1139-54.
Valdés F, Cid A. Micobacterias atípicas. Actas Dermosifiliogr. 2004;95:331-57. DOI: https://doi.org/10.1016/S0001-7310(04)76833-7
García-Martos P, García-Agudo L. Infecciones por micobacterias de crecimiento rápido. Enferm Infecc Microbiol Clin. 2012;30;192-200. DOI: https://doi.org/10.1016/j.eimc.2011.09.017
Da Mata O, Hernández-Pérez R,Corrales H, Cardoso-Leao S, de Waard JH. Seguimiento de un brote de infección en tejido blando causado por Mycobacterium abscessus posterior a la mesoterapia en Venezuela. Enferm Infecc Microbiol Clin. 2010;28:596-601.
Wu TS, Yang CH, Brown-Elliott BA, Chao AS, Leu HS, Wu TL, et al. Postcesarean section wound infection caused by Mycobacterium massiliense. J Microbiol Immunol Infect. 2016;49:955-61. DOI: https://doi.org/10.1016/j.jmii.2015.06.010
Gnatta JR, Sato-Kurebayashi L, Paes-da Silva M. Micobacterias atípicas asociadas a la acupuntura: revisiónintegral. Rev Latino-Am Enfermagem. 2013;21:1-10. DOI: https://doi.org/10.1590/S0104-11692013000100022
Picinin Safe I, Macedo V, Marcelo W, Baia-Da-Silva D, Monique F, Renata S, et al. Nontuberculous mycobacterial infections after aesthetic procedures: comparison of clinical features and treatment. J Clin Aesthet Dermatol. 2021;14(3):46-9.
García-Harana C, Aguilar-Bernier M, Segura-Palacios JM, de Troya-Martín M. Paniculitis por micobacterias atípicas tras mesoterapia. Actas Dermosifiliogr. 2018;109:747. DOI: https://doi.org/10.1016/j.ad.2017.03.027
Ramos A, Roustan G, Lucena JL, Daza RM. Aparición de nódulos subcutáneos después de aplicación de mesoterapia. Enferm Infecc Microbiol Clin. 2011;29:775-7. DOI: https://doi.org/10.1016/j.eimc.2011.05.008
Correa NE, Catano JC, Mejía GI, Teresa R, Beatriz O, Santiago E, et al. Outbreak of mesotherapy-associated cutaneous infections caused by Mycobacterium chelonae in Colombia. Jpn J Infect Dis. 2010;63(2):143-5. DOI: https://doi.org/10.7883/yoken.63.143
Rivera-Olivero IA, Guevara A, Escalona A, Oliver M, Pérez-Alfonzo R, Piquero J, et al. Infecciones en tejidos blandos por micobacterias no tuberculosas secundarias a mesoterapia. ¿Cuánto vale la belleza? Enferm Infecc Microbiol Clin. 2006;24:302-6. DOI: https://doi.org/10.1157/13089664
Zhang X, Liu W, Liu W, Jiang H, Zong W, Zhang G, et al. Cutaneous infections caused by rapidly growing mycobacteria: Case reports and review of clinical and laboratory aspects. Acta Derm Venereol. 2015;95:985-9. DOI: https://doi.org/10.2340/00015555-2105
Mougari F, Guglielmetti L, Raskine L, Sermet-Gaudelus I, Veziris N, Cambau E. Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. Expert Rev Anti Infect Ther. 2016;14(12):1139-54. DOI: https://doi.org/10.1080/14787210.2016.1238304
Franco-Paredes C, Marcos LA, Henao-Martínez AF, Rodríguez-Morales AJ, Villamil-Gómez WE, Gotuzzo E, et al. Cutaneous mycobacterial infections. Clin Microbiol Rev. 2019;32(1):1-25. DOI: https://doi.org/10.1128/CMR.00069-18
Lee MR, Sheng WH, Hung CC, Chong-Jen Y, Li-Na L, Po-Ren H. Mycobacterium abscessus complex infections in humans. Emerg Infect Dis. 2015;21(9):1638-46. DOI: https://doi.org/10.3201/2109.141634
Rébora I, Busso C, Jacob N. Infección cutánea por Mycobacterium chelonae asociada a lipoaspiración. Der matol Argent. 2007;13:195-8.
Schnabel D, Esposito DH, Gaines J, Alison Rh, Barry MA, Feldman KA, et al. Multisite US outbreak of rapidly growing mycobacterial infections as sociated with medical tourism to the Dominican Republic, 2013-2014. Emerg Infect Dis. 2016;22(8):1340-7. DOI: https://doi.org/10.3201/eid2208.151938
Da Mata Jardín O, Hernández-Pérez R, Corrales H, Cardoso-Leao S, De Waard JH. Seguimiento de un brote de infección en tejido blando causado por Mycobacterium abscessus posterior a la mesoterapia en Venezuela. Enferm Infecc Microbiol Clin. 2010;28(9):596-601. DOI: https://doi.org/10.1016/j.eimc.2009.08.003
Galmés-Truyols A, Giménez-Duran J, Bosch-Isabel C. An outbreak of cutaneous infection due to Mycobacterium abscessus associated to mesotherapy. Enferm Infecc Microbiol Clin. 2011;29:510-4. DOI: https://doi.org/10.1016/j.eimc.2011.03.006
Veraldi S, Spigariolo CB, Cusini M. Skin infections by Mycobacterium chelonae following mesotherapy: A report of two cases and review of the literature. J Cosmet Dermatol. 2020;19:1915-7. DOI: https://doi.org/10.1111/jocd.13441
Bae JY, Yun IS, Roh TS, Kim YS. Treatment strategy for skin and soft tissue infections caused by nontuberculous mycobacteria following various procedures. Arch Aesthet Plast Surg. 2021;27(1):3-11. DOI: https://doi.org/10.14730/aaps.2020.02327
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