Epidermolysis bullosa acquisita in a 53-year-old female with extensive cutaneous and mucosal involvement

Reddy Siva Sai Manikanta; K. V. T. Gopal; P. V. Krishnam Raju; N. Krishna Sagar

doi:10.18203/issn.2455-4529.IntJResDermatol20251054

Authors

Reddy Siva Sai Manikanta Department of Dermatology, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India
K. V. T. Gopal Department of Dermatology, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India
P. V. Krishnam Raju Department of Dermatology, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India
N. Krishna Sagar Department of Dermatology, Maharajah’s Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20251054

Keywords:

Epidermolysis bullosa acquisita, Autoimmune blistering disorder, Sub-epidermal blister, Direct immunofluorescence, Mucosal involvement, Type VII collagen

Abstract

Epidermolysis bullosa acquisita (EBA) is a rare autoimmune blistering disorder characterized by subepidermal blisters, typically caused by an autoimmune response against type VII collagen, a key structural component of the dermal-epidermal junction. Here, we report a case of EBA in a 53-year-old female with extensive multiple bullae, erosions over extremities, trunk, genitaila. HPE revealed a sub-epidermal blister with fibrin, neutrophils, and some eosinophils, DIF showed IgG positivity (+3) in a linear pattern along the dermal-epidermal junction. enzyme immunoassay (EIA) for anti-collagen type VII antibodies was positive. Based on clinical features and investigations patient is diagnosed as Epidermolysis Bullosa Acquisita. She was treated with systemic steroids and topical steroids with gradual tapering. This case highlights the importance of early diagnosis and treatment in managing this condition effectively.

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