Integrating Ayurvedic therapies with minoxidil: a randomized, single-blinded, parallel-controlled trial assessing the efficacy and safety of Traya's customized approach for treating male androgenetic alopecia

Sonia Tekchandani; Kalyani Deshmukh; Shuchi Arora; Lymraina Dsilva; Mukta Sachdev; Dhamini P. Murali; Ritambhara; Raghava G. Bhat

doi:10.18203/issn.2455-4529.IntJResDermatol20251017

Authors

Sonia Tekchandani Department of Dermatology, Tender Skin International, Mumbai, Maharashtra, India
Kalyani Deshmukh Dr Deshmukh’s The Skin Clinic, Nashik, Maharashtra, India
Shuchi Arora Department of Product Development, Traya Health, Mumbai, Maharashtra, India
Lymraina Dsilva Department of Product Development, Traya Health, Mumbai, Maharashtra, India
Mukta Sachdev Department of Dermatology, MS Clinical Research, Bangalore, Karnataka, India
Dhamini P. Murali Department of Dermatology, MS Clinical Research, Bangalore, Karnataka, India
Ritambhara Department of Dermatology, MS Clinical Research, Bangalore, Karnataka, India
Raghava G. Bhat Department of Dermatology, MS Clinical Research, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20251017

Keywords:

Male androgenetic alopecia, Holistic hair treatment regimen, Hair growth

Abstract

Background: Male androgenetic alopecia (MAA) is the most common form of hair loss in men, influenced by genetics, hormonal imbalances, nutritional deficiencies, and stress. While treatments like minoxidil address symptoms, they do not target underlying causes. This study compares the effectiveness of a customized regimen versus minoxidil in treating male pattern hair loss (MPHL) in men with MAA stages 2-4.

Methods: A 6-month, single-blinded, randomized, controlled study with 135 adult males (stages 2-4 MAA) was conducted. Participants were assigned to group A (holistic hair treatment regimen), group B (minoxidil), or group C (placebo). Baseline and follow-up assessments (2, 4, and 6 months) included dermatological and Trichoscan® assessments, imaging, and self-assessment questionnaires.

Results: 6 months of TrichoScan® assessment showed a 3.16-fold increase in hair density for group A compared to group B and 5.82-fold compared to group C. Groups A and B showed significant improvements over group C.

Conclusions: The holistic hair treatment regimen proved to be more effective than minoxidil for treating MAA stages 2-4, offering a promising alternative to traditional treatments.

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References

York K, Meah N, Bhoyrul B, Sinclair R. A review of treatments for male pattern hair loss. Expert Opin Pharmacother. 2020;21(5):603-12. DOI: https://doi.org/10.1080/14656566.2020.1721463

Oiwoh SO, Enitan AO, Adegbosin OT, Akinboro AO, Onayemi EO. A review of androgenetic alopecia. Niger Postgrad Med J. 2024;31(2):85-92. DOI: https://doi.org/10.4103/npmj.npmj_47_24

Liu LP, Wariboko MA, Hu X, Wang ZH, Wu Q, Li YM. A scoping review of factors associated with early-onset androgenetic alopecia. PLoS One. 2024;19(3):e0299212. DOI: https://doi.org/10.1371/journal.pone.0299212

Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial on the effectiveness of botanically derived 5-alpha-reductase inhibitors in treating androgenetic alopecia. J Altern Complement Med. 2002;8(2):143-52. DOI: https://doi.org/10.1089/acm.2002.8.143

Bin Rubaian NF, Alzamami HFA, Amir BA. An overview of commonly used natural alternatives for treating androgenetic alopecia, with a focus on rosemary oil. Clin Cosmet Investig Dermatol. 2024;17:2495-503. DOI: https://doi.org/10.2147/CCID.S470989

Dhariwala MY, Ravikumar P. An overview of herbal alternatives for treating androgenetic alopecia. J Cosmet Dermatol. 2019;18(4):966-75. DOI: https://doi.org/10.1111/jocd.12930

Gupta AK, Talukder M, Venkataraman M, Bamimore MA. A comprehensive review of minoxidil. J Dermatol Treat. 2022;33(4):1896-906.

Messenger AG, Rundegren J. Minoxidil: mechanisms of action on hair growth. Br J Dermatol. 2004;150(2):186-94. DOI: https://doi.org/10.1111/j.1365-2133.2004.05785.x

Gupta AK, Talukder M, Venkataraman M, Bamimore MA. Minoxidil: a comprehensive review. J Dermatol Treat. 2021;33(4):1896-906.

Gupta AK, Talukder M, Venkataraman M, Bamimore MA. Minoxidil: a comprehensive review. J Dermatol Treat. 2022;33(4):1896-906. DOI: https://doi.org/10.1080/09546634.2021.1945527

Lowenthal DT, Affrime MB. Pharmacology and pharmacokinetics of minoxidil. J Cardiovasc Pharmacol. 1980;2(2):S93-S106. DOI: https://doi.org/10.1097/00005344-198000022-00002

Dlova NC, Jacobs T, Singh S. Pericardial, pleural effusion and anasarca: a rare complication of low-dose oral minoxidil for hair loss. JAAD Case Rep. 2022;28:94-6. DOI: https://doi.org/10.1016/j.jdcr.2022.07.044

Reichgott MJ. Minoxidil and pericardial effusion: an idiosyncratic reaction. Clin Pharmacol Ther. 1981;30:64-70. DOI: https://doi.org/10.1038/clpt.1981.128

Trüeb RM, Caballero-Uribe N, Luu NC, Dmitriev A. Serious complication of low-dose oral minoxidil for hair loss. JAAD Case Rep. 2022;30:97-8. DOI: https://doi.org/10.1016/j.jdcr.2022.09.035

Lourith N, Kanlayavattanakul M. Hair loss and herbal treatments. J Cosmet Dermatol. 2013;12(3):210-22. DOI: https://doi.org/10.1111/jocd.12051

Yerram C, Jillella A, Reddy V. Effects of Withania somnifera root extract serum application on hair health in healthy adults: A prospective, double-blind, randomized, parallel, placebo-controlled study. J Ayurveda Integr Med. 2023;14(6):100817. DOI: https://doi.org/10.1016/j.jaim.2023.100817

Wongrakpanich A, Leanpolchareanchai J, Morakul B, Parichatikanond W, Teeranachaideekul V. Phyllanthus emblica extract-loaded transfersomes for hair follicle targeting: Phytoconstituents, characterization, and hair growth promotion. J Oleo Sci. 2022;71(7):1085-96. DOI: https://doi.org/10.5650/jos.ess21425

Mysore V, Arghya A. Hair oils: Revisiting indigenous knowledge. Int J Trichol. 2022;14(3):84-90. DOI: https://doi.org/10.4103/ijt.ijt_189_20

Gottumukkala VR, Annamalai T, Mukhopadhyay T. Phytochemical investigation and hair growth studies on the rhizomes of Nardostachys jatamansi DC. Pharmacogn Mag. 2011;7(26):146-50. DOI: https://doi.org/10.4103/0973-1296.80674

Ufomadu P. A review of complementary and alternative supplements for dermatologic effectiveness in androgenetic alopecia. Proc (Bayl Univ Med Cent). 2023;37(1):111-7. DOI: https://doi.org/10.1080/08998280.2023.2263829

Teeranachaideekul V, Parichatikanond W, Junyaprasert VB, Morakul B. Pumpkin seed oil-loaded niosomes for topical application: 5α-reductase inhibition, anti-inflammatory effects, and in vivo anti-hair loss activity. Pharmaceuticals (Basel). 2022;15(8):930. DOI: https://doi.org/10.3390/ph15080930

Basch E, Ulbricht C, Hammerness P, Bevins A, Sollars D. Thyme (Thymus vulgaris L.) and thymol: A review. J Herb Pharmacother. 2004;4(1):49-67. DOI: https://doi.org/10.1080/J157v04n01_07

Oh JY, Park MA, Kim YC. Peppermint oil promotes hair growth without toxic signs. Toxicol Res. 2014;30(4):297-304. DOI: https://doi.org/10.5487/TR.2014.30.4.297

Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The role of vitamins and minerals in hair loss: A review. Dermatol Ther (Heidelb). 2019;9(1):51-70. DOI: https://doi.org/10.1007/s13555-018-0278-6

Stephens TJ, Berkowitz S, Marshall T, Kogan S, Raymond I. A Prospective Six-month Single-blind Study Evaluating Changes in Hair Growth and Quality Using a Nutraceutical Supplement in Men and Women of Diverse Ethnicities. J Clin Aesthet Dermatol. 2022;15(1):21-6.

Ablon G, Kogan S. A randomized, double-blind, placebo-controlled study of a nutraceutical supplement for promoting hair growth in perimenopausal, menopausal, and postmenopausal women with thinning hair. J Drugs Dermatol. 2021;20(1):55-61. DOI: https://doi.org/10.36849/JDD.5701

Hosking AM, Juhasz M, Atanaskova Mesinkovska N. Complementary and Alternative Treatments for Alopecia: A Comprehensive Review. Skin Appendage Disord. 2019;5(2):72-89. DOI: https://doi.org/10.1159/000492035

Majeed M, Majeed S, Nagabhushanam K, Mundkur L, Neupane P, Shah K. Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall. Clin Cosmet Investig Dermatol. 2020;13:691-700. DOI: https://doi.org/10.2147/CCID.S271013

Patel M, Tuli N, Patel N, Merja A. A Clinical Evaluation of the Safety, Efficacy, and Tolerability of the Soulflower Rosemary Redensyl Hair Growth Serum, Tetragain™, in Healthy Female Subjects for the Treatment of Alopecia: Promoting Hair Growth and Reducing Gray Hair. Cureus. 2025;17(1):e77066. DOI: https://doi.org/10.7759/cureus.77066

Thor D, Pagani A, Bukowiecki J, Houschyar KS, Kølle S-FT, Wyles SP, et al. A Novel Hair Restoration Technology Counteracts Androgenic Hair Loss and Promotes Hair Growth in A Blinded Clinical Trial. J Clin Med. 2023;12(2):470. DOI: https://doi.org/10.3390/jcm12020470

Dhurat R, Saraogi P. Hair evaluation methods: merits and demerits. Int J Trichology. 2009;1(2):108-19. DOI: https://doi.org/10.4103/0974-7753.58553