Unveiling the clinical profiles and triggers of adverse cutaneous drug reactions at Jagakarsa general hospital
DOI:
https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20250431Keywords:
ACDR, Antibiotics, RetrospectiveAbstract
Background: Adverse cutaneous drug reactions (ACDR) are common side effects of drug use. This study aims to analyze the characteristics of patients, clinical profiles and risk factors associated with ACDR in patients visiting the Emergency Department of RSUD Jagakarsa.
Methods: This study is a retrospective study by analyzing medical records of patients who experienced ACDR from November 2023 to October 2024. Variables analyzed included demographic data, clinical profiles, causative drugs, onset time and risk factors.
Results: There were 40 cases of ACDR with a higher prevalence in females. Patient age varied with a mean of 35.80±16.54 years. The most common clinical presentation was urticaria (42.5%), followed by angioedema (22.5%) and maculopapular rash (17.5%). The most common drugs causing ACDR were antibiotics (32.5%), NSAIDs (25%) and antihypertensives (12.5%). Most cases (70%) had an onset of less than 24 hours. Associated risk factors included a previous history of drug allergy and comorbidities such as diabetes mellitus and hypertension.
Conclusions: Increased awareness of ACDR and preventive efforts are needed to reduce the incidence and impact of ACDR.
Metrics
References
Modi A, Desai M, Shah S, Shah B. Analysis of Adverse Cutaneous Drug Reactions reported at the regional ADR monitoring Center. Indian J Dermatol. 2019;64:250. DOI: https://doi.org/10.4103/ijd.IJD_682_16
Del BR, Liy-Wong C. Drugs and the skin: A concise review of cutaneous adverse drug reactions. Br J Clin Pharmacol. 2024;90(8):1838–55. DOI: https://doi.org/10.1111/bcp.15490
Valinciute-Jankauskiene A, Kubiliene L. Adverse drug reaction reporting by patients in 12 european countries. Int J Environ Res Public Health. 2021;18(4):1–8. DOI: https://doi.org/10.3390/ijerph18041507
Maharani L, Yugatama A. Prevalence of adverse drug reaction in Indonesia: A systematic review. J Appl Pharm Sci. 2023;13(8):55–67. DOI: https://doi.org/10.7324/JAPS.2023.91550
Budianti WK, Pradana P, Ramadhiani M. The role and procedure of skin testing to identify the cause in cases of adverse drug reactions. MDVI. 2019;45(3):1-9 https://doi.org/10.33820/mdvi.v45i3.34 DOI: https://doi.org/10.33820/mdvi.v45i3.34
Oktarina DAM, Sophiati M, Moha EMR, Waskito F, Soebono H. A Five-Year Review of Adverse Cutaneous Drug Reaction in a Tertiary Care Hospital in Yogyakarta, Indonesia. Berk Ilmu Kesehatan Kulit dan Kelamin. 2021;33(3):150. DOI: https://doi.org/10.20473/bikk.V33.3.2021.150-155
Khot AM, Chaukimath SP, Ajit J, Leela H. A study of cutaneous adverse drug reactions; clinical/ morphological pattern & causative agents reported in an ADR monitoring centre in a tertiary care Hospital of North Karnataka. Biomed Pharmacol J. 2020;13(3):1549–54. DOI: https://doi.org/10.13005/bpj/2029
Sari, Agnes RP. Skin reactions to drug use. Fakultas Kedokteran Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada. 2024. Available at: https://fkkmk.ugm.ac.id. Accessed on 21 August 2024.
Vora RV, Patel TB, Tandel JJ, Patel JK, Polra RV. Adverse cutaneous drug reactions at a rural-based tertiary health-care center in Gujarat: An eleven-year study. Indian Dermatol Online J. 2022;14(1):50-4. DOI: https://doi.org/10.4103/idoj.idoj_85_22
Marsh DES. Risk factors for adverse drug reactions. MSD Manual. 2023. Available from: https://www.msdmanuals.com. Accessed on 21 September 2024.
Mortazavi H, Mortazavi A, Rostami A. A study of severe Adverse Cutaneous Drug Reactions in Iranian patients. Iran J Dermatol. 2021;24(4):267-73.
Ashifha S, Vijayashree J, Vudayana K. A study of Adverse Cutaneous Drug Reactions at a tertiary care center in Andhra Pradesh, India. Cureus. 2023;15(4):56-9. DOI: https://doi.org/10.7759/cureus.37596
Yang F, Chen Z, Chen Sa, Zhu Q, Wang L, Xiong H, et al. Clinical profile of cutaneous adverse drug reactions: a retrospective study of 1883 hospitalized patients from 2007 to 2016 in Shanghai, China. Eur J Dermatol. 2020;30(1):24-31. DOI: https://doi.org/10.1684/ejd.2020.3713
Zucker I, Prendergast BJ. Sex differences in pharmacokinetics predict adverse drug reactions in women. Biol Sex Differ. 2020;11:32. DOI: https://doi.org/10.1186/s13293-020-00308-5
Kowalska J, Wrześniok D. Skin-related adverse reactions induced by oral antidiabetic drugs—a review of literature and case reports. Pharmaceuticals. 2024;17(7):847. DOI: https://doi.org/10.3390/ph17070847
Hidajat D, Lindriati NL, Purwaningsih NW. Hypersensitivity reactions of the skin due to non-steroidal anti-inflammatory drugs. Journal of Medicine. 2019;8(3):6.
Makmur O, Anggraini YE, Nugraha DP. Allergic drug eruption in the dermatology and venereal disease polyclinic of Arifin Achmad Regional Hospital. Malay Health J. 2018;1(2):53-9. DOI: https://doi.org/10.26891/jkm.v1i2.2018.51-59
Castro CF, Teixeira CA, Fernandes NC, Matos GC. Severe cutaneous adverse reactions to drugs: a case series study. Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde. 2020;11(3):471-6. DOI: https://doi.org/10.30968/rbfhss.2020.113.0471
Naidu S, Rani V. Profile of adverse drug reactions in a tertiary care hospital: a cross sectional study. department of pharmacology, pes university institute of medical sciences, electronic city campus, bengaluru, karnataka, india. Asian J Pharm Clin Res. 2024;17(6):178-9. DOI: https://doi.org/10.22159/ajpcr.2024v17i6.52049
Kushwaha V, Agrawal P, Kumar A, Kumar P, Shoraisham BK, Goel S. Analysis of the pattern of adverse drug reactions at a tertiary care hospital: a cross-sectional study. department of pharmacology, gsvm medical college, kanpur.European Journal of Pharmaceutical and Medical Research. 2023;10(12)33.
Downloads
Published
How to Cite
Issue
Section
