The effect of topical retinoids in treatment of acne vulgaris in Khartoum Teaching Dermatological Hospital

Rania A. S. Ahmed Ali; Zainab M. R. Mohamed

doi:10.18203/issn.2455-4529.IntJResDermatol20243338

Authors

Rania A. S. Ahmed Ali Aljazeera Medical Center, Doha, Qatar
Zainab M. R. Mohamed Dermatology Department, Medical Services, Qatar

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20243338

Keywords:

Acne vulgaris, Topical retinoid, Propionibacterium acnes, Acne scarring

Abstract

Background: Acne vulgaris is a chronic inflammatory skin disease affecting approximately 80% of young adults and adolescents. Prolonged therapy is often required for satisfactory results. Topical retinoids play a central role in acne treatment, with evidence supporting their efficacy in achieving significant improvements in acne symptoms. This study aimed to assess the effectiveness of topical retinoids in treating acne vulgaris among patients at Khartoum Dermatology and Venereal Teaching Hospital from August 2019 to August 2020.

Methods: A non-randomized interventional study was conducted at Khartoum Dermatology Teaching Hospital, covering patients diagnosed with mild to moderate acne vulgaris. Data were entered, cleaned, and analysed using statistical package for the social sciences (SPSS) version 25.0.

Results: The study included 100 patients. Of these, 38% were aged 25-35 years, and 70% were female. 92% had experienced acne symptoms for more than six months. Regarding treatment duration, 87% used topical retinoids for more than three months. Clinical improvement was observed in 83% of patients, while 14% showed no improvement, and 3% experienced worsened symptoms.

Conclusions: Topical retinoids are effective in treating mild and moderate acne vulgaris.

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References

Gold MH, Baldwin H, Lin T. Management of comedonal acne vulgaris with fixed‐combination topical therapy. J Cosmet Dermatol. 2018;17(2):227-31.

Strauss JS, Krowchuk DP, Leyden JJ, Lucky AW, Shalita AR, Siegfried EC, et al. Guidelines of care for acne vulgaris management. J Am Acad Dermatol. 2007;56(4):651-63.

Tan X, Al-Dabagh A, Davis SA, Lin HC, Balkrishnan R, Chang J, Feldman SR. Medication adherence, healthcare costs and utilization associated with acne drugs in Medicaid enrollees with acne vulgaris. Am J Clin Dermatol. 2013;14(3):243-51.

Thiboutot D, Gollnick H, Bettoli V, Dréno B, Kang S, Leyden JJ, et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol. 2009;60(5):S1-50.

Gollnick HP, Bettoli V, Lambert J, Araviiskaia E, Binic I, Dessinioti C, et al. A consensus‐based practical and daily guide for the treatment of acne patients. J Eur Acad Dermatol Venereol. 2016;30(9):148090.

Plewig GK. A. Acne and Rosacea. New York: Springer. 2000.

Thielitz A, Abdel‐Naser MB, Fluhr JW, Zouboulis CC, Gollnick H. Topical retinoids in acne–an evidence‐based overview. J German Soc Dermatol. 2008;6(12):1023-31.

Thielitz A, Helmdach M, Röpke EM, Gollnick H. Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents. Br J Dermatol. 2001;145(1):19-27.

Czernielewski J, Michel S, Bouclier M, Baker M, Hensby C. Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne. J Eur Acad Dermatol Venereol. 2001;15:5-12.

Michel S, Jomard A, Demarchez M. Pharmacology of adapalene. Br J Dermatol. 1998;139:3-7.

Lavker RM, Leyden JJ, Thorne EG. An ultrastructural study of the effects of topical tretinoin on microcomedones. Clin Ther. 1992;14(6):773-80.

Fabbrocini G, Annunziata MC, D'arco V, De Vita V, Lodi G, Mauriello MC, et al. Acne scars: pathogenesis, classification and treatment. Dermatol Res Pract. 2010;14:2010.

Pandya AG, Guevara IL. Disorders of hyperpigmentation. Dermatol Clin. 2000;18(1):91-8.

Leyden JJ, Shalita A, Thiboutot D, Washenik K, Webster G. Topical retinoids in inflammatory acne: a retrospective, investigator-blinded, vehicle controlled, photographic assessment. Clin Ther. 2005;27(2):216-24.

Shalita AA, Weiss JS, Chalker DK, Ellis CN, Greenspan A, Katz HI, et al. A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris: a multicenter trial. J Am Acad Dermatol. 1996;34(3):482-5.

Webster GF, Berson D, Stein LF, Fivenson DP, Tanghetti EA, Ling M. Efficacy and tolerability of once-daily tazarotene 0.1% gel versus once-daily tretinoin 0.025% gel in the treatment of facial acne vulgaris: a randomized trial. Cutis. 2001;67(6):4.

Webster GF, Guenther L, Poulin YP, Solomon BA, Loven K, Lee J. A multicenter, double-blind, randomized comparison study of the efficacy and tolerability of once-daily tazarotene 0.1% gel and adapalene 0.1% gel for the treatment of facial acne vulgaris. Cutis. 2002;69(2):4.

Purdy S, de Berker D. Acne vulgaris. BMJ Clin Evid. 2011;2011:1714.

Gebauer K. Acne in adolescents. Aust Fam Phys. 2017;46(12):892.

Leyden JJ, Shalita A, Thiboutot D, Washenik K, Webster G. Topical retinoids in inflammatory acne: a retrospective, investigator-blinded, vehicle controlled, photographic assessment. Clin Ther. 2005;27(2):216-24.

Kolli SS, Pecone D, Pona A, Cline A, Feldman SR. Topical retinoids in acne vulgaris: a systematic review. Am J Clin Dermatol. 2019;23:1-21.

Thielitz A, Abdel‐Naser MB, Fluhr JW, Zouboulis CC, Gollnick H. Topical retinoids in acne–an evidence‐based overview. J Dtsch Dermatol Ges. 2008;6(12):1023-31.