The evaluation of serum vitamin D3 in androgenetic alopecia:  a case-control study

Raj Kumar; Swale Iftikhar; Durga Prasad Dubey; Urjasweta Singh; Anil Kumar Gupta

doi:10.18203/issn.2455-4529.IntJResDermatol20241284

Authors

Raj Kumar Department of Dermatology Venereology and Leprology, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India
Swale Iftikhar Department of Dermatology Venereology and Leprology, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India
Durga Prasad Dubey Department of Dermatology Venereology and Leprology, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India
Urjasweta Singh Department of Dermatology Venereology and Leprology, Autonomous State Medical College, Kaushambi, Uttar Pradesh, India
Anil Kumar Gupta Department of Dermatology Venereology and Leprology, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20241284

Keywords:

Vitamin D, AGA, Non-scarring alopecia, Alopecia

Abstract

Background: Androgenetic alopecia (AGA) is a common hereditary condition characterized by progressive hair loss influenced by androgens. Vitamin D has been implicated in various hair disorders, yet its association with AGA, particularly in South Asian populations, remains inconclusive.

Methods: We conducted a case-control study involving 100 male subjects from eastern Uttar Pradesh, India, comprising 50 AGA cases and 50 age-matched controls. Serum vitamin D levels were measured, and participants underwent clinical evaluations. Statistical analyses were performed using unpaired t tests and chi-square tests.

Results: Vitamin D deficiency (<20 ng/ml) was significantly more prevalent in AGA cases (56%) compared to controls (24%) (p<0.001), with an odds ratio of 4.0303. Mean serum vitamin D levels were significantly lower in cases (33.1±10.6 ng/ml) than controls (40.3±9.51 ng/ml) (p=0.0005). Severe AGA cases exhibited lower vitamin D levels compared to mild to moderate cases, although the difference was not statistically significant (p=0.32).

Conclusions: This study highlights the importance of vitamin D in AGA pathogenesis and suggests the need for routine monitoring of serum vitamin D levels in AGA patients. Further large-scale studies are warranted to confirm these findings and investigate the efficacy of vitamin D supplementation as a therapeutic intervention for AGA.

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