A rare case of azathioprine induced anagen effluvium and plica neuropathica

Authors

  • Manish Rijhwani Department of Dermatology, Venereology and Leprosy, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India
  • Meet D. Patel Department of Dermatology, Venereology and Leprosy, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India
  • Amrit Malik Department of Dermatology, Venereology and Leprosy, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India
  • Manisha Nijhawan Department of Dermatology, Venereology and Leprosy, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20240973

Keywords:

Anagen effluvium, Azathioprine, Plica neuropathica

Abstract

Anagen effluvium is a type of hair loss that results from a sudden decrease in the metabolic activity of the hair follicle’s matrix cells. The condition is commonly associated with cancer treatments such as chemotherapy and radiation, but can also be caused by other factors. Plica neuropathica, on the other hand, is a condition where hair on the scalp becomes irreversibly matted. It is often linked to psychiatric disturbances, poor hair care, scalp infestations, and the use of ionic surfactants in shampoos. In rare cases, it has also been associated with certain medications. Here we present a rare case of a 16-year-old female who was on azathioprine and was diagnosed with an overlap of both conditions.

Metrics

Metrics Loading ...

References

Sperling LC. Hair and systemic disease. Dermatol Clin. 2001;19(4):711-26.

Le Page JF. On Neuropathic Plica. Br Med J. 1884; 1(1204):160.

Kumar PN, Antony B, Chakravarthy A, Koyamu AM. Plica neuropathica (polonica) in schizophrenia - a case report and review of literature. Indian J Psychiatr. 2001;43(3):281-3.

Vogt A, McElvee K, Blume-Peytavi U. Biology of the hair follicle. In: Blume-Peytavi U, Tosti A, Whiting D, Trueb R, editors. Textbook on hair - From basic science to clinical application. Berlin: Springer Verlag; 2008;3:1-22.

Kanwar AJ, Narang T. Anagen effluvium. Indian J Dermatol Venereol Leprol. 2013;79(5):604-12.

Sharma R, Poddar S, Podder I. Azathioprine Induced Anagen Effluvium- An Uncommon Adverse Effect of a Commonly Used Drug. Indian J Dermatol. 2022; 67(6):815-7.

Bhokare A. Azathioprine-induced alopecia as an early clinical marker of its myelotoxicity. Indian J Drug Dermatol. 2017;3(1):40-7.

Marshall J, Parker C. Felted hair untangled. J Am Acad Dermatol. 1989;20(4):688-90.

Kwinter J, Weinstein M. Plica neuropathica: novel presentation of a rare disease. Clin Exp Dermatol. 2006;31(6):790-2.

Joshi R, Singh S. Plica Neuropathica (Plica polonica) Following Azathioprine-induced Pancytopenia. Int J Trichol. 2010;2(2):110-2.

Downloads

Published

2024-04-24

Issue

Section

Case Reports