Symmetrical acrokeratoderma: a case series
DOI:
https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20240971Keywords:
Symmetrical acrokeratoderma, White maceration, Aqua-exacerbated symmetrical acral hyperkeratosisAbstract
Symmetrical acrokeratoderma is rare keratinization disorder which is characterized by symmetrical acral brown to black hyperpigmented keratotic plaques. In this case series, all three patients presented with asymptomatic symmetrical thick raised dark brown skin lesions with rough surface on flexural surface of wrists and dorsum of hands and feet. Palms and soles were spared in all three patients. White maceration and swelling of skin lesions were noticed after soaking in water. All Patients showed good response to oral acitretin and patients were asked for regular follow up every 4 weekly.
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Xiao Q, Zhou R, Li Y, Zhao L, Xiong L, Tang J, et al. Symmetrical Acrokeratoderma: A Case Report and Literature Review. Clin Cosmet Investig Dermatol. 2022;15:247-52.
Fan YM, Li SF, Yang YP, Chen QX, Li W. Is acquired symmetrical acrokeratoderma a new dermatosis? Two case reports and Chinese literature review. Int J Dermatol. 2010;49:647-52.
Chen W, Song Z, Young CC, Hao F. Symmetrical acral keratoderma revisited: proposal for a new term pigmented carpotarsal hyperkeratosis. J Eur Acad Dermatol Venereol. 2019;33:277-82.
Vinay K, Sawatkar GU, Saikia UN, Dogra S. Symmetrical acrokeratoderma: a case series in Indian patients. Orphanet J Rare Dis. 2016;11(1):156.
Nomura T, Takeda M, Jin TP. Symmetrical acral keratoderma: a waxing and waning scaly pigmented skin lesions on the acral extremities. J Dermatol. 2021;48:e151.
Chen SY, Liu HT, Ho JC. Acanthosis nigricans limited in acral areas-acral acanthosis nigricans. Dermatol Sinica. 1991;9:55-60.
Bishnoi A, Vinay K, Dogra S. Pigmented aqua-exacerbated symmetrical acral hyperkeratosis. J Eur Acad Dermatol Venereol. 2019;33:e187-229.
Liu Z, Zhou Y, Chen RY, Shi G, Li W, Li SJ, et al. Symmetrical acrokeratoderma: A peculiar entity in China? Clinicopathologic and immunopathologic study of 34 new cases. J Am Acad Dermatol. 2014; 70:533-8.
Li CX, Han CL, Zeng K, Zhang XB, Ma ZL. Clinical, demographic and histopathological features of symmetrical acral keratoderma. Br J Dermatol. 2014; 170:948-51.
Chen P, Sun S, Zeng K. Exome sequencing identifies a TCF4 mutation in a Chinese pedigree with symmetrical acral keratoderma. J Eur Acad Dermatol Venereol. 2018;32:1204-8.
Voss KE, Bollag RJ, Fussell N, By C, Sheehan DJ, Bollag WB. Abnormal aquaporin-3 protein expression in hyperproliferative skin disorders. Arch Dermatol Res. 2011;303:591-600.
Li CX, Wen J, Zeng K, Tian X, Li XM, Zhang XB. Ultrastructural study of symmetrical acral keratoderma. Ultrastruct Pathol. 2014;38:420-4.
Luo DQ, Li Y, Huang YB, Wu LC, He DY. Aquagenic syringeal acrokeratoderma in an adult man: case report and review of the literature. Clin Exp Dermatol. 2009;34:e907-9.
Darlenski R, Tsankov N. Aquagenic syringeal acrokeratoderma. J Dtsch Dermatol Ges. 2012;10: 198.
Chiang CY, Tsai TF. Botulinum toxin type A injection in the treatment of acquired symmetrical acrokeratoderma: One case report. Dermatol Ther. 2020;33(6):e14442.
Garayar Cantero M, Delgado Mucientes C, Muñoz Fernández-Lomana C. Use of botulinum toxin in the treatment of aquagenic keratoderma: one case report. Dermatol Ther. 2018;31:e12689.
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