Hypopyon sign: a half full or half empty scenario

Authors

  • K. Manoharan Department of Dermatology, Venereology & Leprosy, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India
  • Vignesh N. R. Department of Dermatology, Venereology & Leprosy, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India
  • Sukanya G. Department of Dermatology, Venereology & Leprosy, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India
  • Ashna Jaffrey Department of Dermatology, Venereology & Leprosy, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20233879

Keywords:

Pemphigus foliaceous, Pemphigus vulgaris, Hypopyon sign, Subcorneal pustular dermatosis, Sneddon-Wilkinson disease, Direct immunofluorescence test

Abstract

The term "half-half blister" or the "hypopyon sign" refers to small vesicles that evolve into pustules, with the pus typically concentrating in the lower half of the vesicle. There is typically a transverse fluid level with purulent material at the bottom. This sign is usually not exclusive to a particular dermatological condition as it is seen in cases of subcorneal pustular dermatosis (Sneddon-Wilkinson disease), pyodermas and secondary infected vesicobullous disorders (such as pemphigus, bullous pemphigoid, and linear IgA dermatosis).

References

Danish M, Patel VM, Gaurav V. Hypopyon sign in dermatology. Indian J Dermatol Venereol Leprol. 2023;27:1-5.

Singh S, Gupta S, Chaudhary R. Hypopyon sign in pemphigus vulgaris and pemphigus foliaceus. Int J Dermatol. 2009;48(10):1100-2.

Taneja N, Arava S, Gupta V. Hypopyon sign in pemphigus vulgaris. Indian J Dermatol Venereol Leprol. 2023;89(3):463.

Madke B, Nayak C. Eponymous signs in dermatology. Indian Dermatol J. 2012;3(3):159-65.

Rather S, Yaseen A, Hassan I. Half and half blisters in pemphigus vulgaris: A diagnostic quandary. Indian Dermatol J. 2016;7(4):331-2.

Pacheco D, Lopes L, Soares-Almeida L, Marques MS, Filipe P. Half-half blisters in bullous pemphigoid successfully treated with adjuvant high-dose intravenous immunoglobulin. Acta Dermatovenerol Alp Panonica Adriat. 2012;21:59-61.

Sussman M, Napodano A, Huang S, Are A, Hsu S, Motaparthi K. Pustular psoriasis and acute generalized exanthematous pustulosis. Medicina. 2021;57(10):1004.

Gorris A, Weiss D, Kogler H, Szépfalusi Z, Karlhofer F, Handisurya A, et al. Hypopyon sign as an unusual complication of varicella infection in a girl with atopic dermatitis. Wiener Medizinische Wochenschrift. 2021;171(3):61.

Chandwar K, Dogga P, Dixit J, Ekbote D, Sahoo RR, Wakhlu A. Half-filled or half-empty: Conundrum of “Hypopyon Sign” in pustular psoriasis. Indian J Rheumatol. 2022;17(3):318-9.

Amrani A, Sil A, Das A. Cutaneous signs in infectious diseases. Indian J Dermatol Venereol Leprol. 2022;88(4):569-75.

Taudorf EH, Jemec GB, Hay RJ, Saunte DM. Cutaneous candidiasis–an evidence‐based review of topical and systemic treatments to inform clinical practice. J Eur Acad Dermatol Venereol. 2019; 33(10):1863-73.

James KA, Culton DA, Diaz LA. Diagnosis and clinical features of pemphigus foliaceus. Dermatol Clin. 2011;29(3):405-12.

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Published

2023-12-22