Cetyl alcohol, stearyl alcohol and colloidal oatmeal-based gentle skin cleanser in management of dry and sensitive skin: a cross-sectional study
Keywords:Dry skin, Sensitive skin, Moisturizing, Itchiness, Pollutant, Irritation
Background: Effective skin cleansing is vital for maintaining skin health and appearance. An ideal skin cleaner retains moisture, removes oils, sweat, and dirt without causing irritation or dehydration. This study was designed to evaluate the efficacy, safety, tolerability and usage trends of a gentle skin cleanser containing cetyl alcohol, stearyl alcohol and colloidal oatmeal for individuals having dry and sensitive skin.
Methods: We conducted a retrospective review at 102 centres, focusing on individuals aged 18 to 65 years with atopic dermatitis and dry skin conditions who required the use of gentle skin cleanser. Total 568 cases were taken; 488 cases of dry and sensitive skin were further analysed over a 2-week study period.
Results: Gentle skin cleanser exhibited significant reduction (p<0.0001) in skin dryness, itchiness and irritation by 4.42±1.92 (63.38%), 4.03±2.71 (49.38%) and 4.44±2.07 (65.58%) respectively in participants with dry skin and by 4.25±1.48 (58.49%), 3.26±3.22 (18.02%) and 4.42±1.56 (63.23%) in participants with sensitive skin after its regular usage. Participants provided positive feedback and expressed overall satisfaction with the study product.
Conclusions: Skin cleanser was efficacious and well-tolerable in participants in providing moisturizing, soothing, exfoliating, and antioxidant effects making it a preferred primary choice for managing dry and sensitive skin. The cleanser effectively cleansed excess oil, dirt, dead cells, microorganisms, and sweat providing a gentle and mild experience, in daily skin care.
Duarte I, Silveira JEPS, Hafner MFS, Toyota R, Pedroso DMM. Sensitive skin: review of an ascending concept. An Bras Dermatol. 2017;92(4):521-5.
Farage MA, Katsarou A, Maibach HI. Sensitive skin. Sensory, clinical, and physiological factors. In: Borel AO, Paye M, Maibach HI, editors. Handbook of Cosmetic Science and Technology. 4th ed. Boca Raton: CRC Press/Taylor and Francis Grou. 2014;59-69.
Farage MA. The prevalence of sensitive skin. Front Med. 2019;6:98.
Misery L, St€ander S, Szepietowski JC et al. Definition of sensitive skin: an expert position paper from the special interest group on sensitive skin of the international forum for the Study of Itch. Acta Derm Venereol 2017; 97: 4–6.
Draelos ZD. Sensitive skin: perceptions, evaluation, and treatment. Am J Contact Dermat. 1997;8(1):67-78.
Mukhopadhyay P. Cleansers and their role in various dermatological disorders. Indian J Dermatol. 2011;56(1):2-6.
Kuehl BL, Fyfe KS, Shear NH. Cutaneous cleansers. Skin Therapy Lett. 2003;8(3):1-4.
Kligman AM, Sadiq I, Zhen Y, Crosby M. Experimental studies on the nature of sensitive skin. Skin Res Technol. 2006;12(2):217-22.
Wellner K, Wohlrab W. Quantitative evaluation of urea in stratum corneum of human skin. Arch Dermatol Res. 1993;285(4):239-40.
Lode´n M, Boström P, Kneczke M. The distribution and keratolytic effect of salicylic acid and urea in human skin. Skin Pharmacol. 1995;8(4):173-8.
Batt MD, Fairhurst E. Hydration of the stratum corneum. Int J Cosmet Sci. 1986;8(6):253-6.
Lechner A, Lahmann N, Lichterfeld-Kottner A. Dry skin and the use of leave-on products in nursing care: A prevalence study in nursing homes and hospitals. Nursing Open. 2019;6(1):189-96.
Keen MA, Hassan I. Vitamin E in Dermatology. Indian Dermatol Online J. 2016;7(4):311-5.
Spencer TS. Dry skin and skin moisturizers. Clin Dermatol. 1988;6(3):24-8.
Castoryl Maleate CAS. Zhonglan Industry. Zhonglan Industry. Available at: https://zhonglanindustry.com/product/castoryl-maleate-cas-241153-84-4/. Accessed on 25 February, 2023.
Buraczewska I, Berne B, Lindberg M. Changes in skin barrier function following long-term treatment with moisturizers, a randomized controlled trial. Brit J Dermatol. 2007;156:492-8.
Verdier-Sévrain S, Bonté F. Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol. 2007;6(2):75-82.
Choi EH, Man MQ, Wang F. Is endogenous glycerol a determinant of stratum corneum hydration in humans? J Invest Dermatol. 2005;125:288-93.
Breternitz M, Kowatzki D, Langenauer M. Placebo-controlled, double-blind, randomized, prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: biophysical and clinical evaluation. Skin Pharmacol Physiol. 2007;21:39-45.
Pinar O, Kasar SD, Ekiz O, Zennure T, Ilknur B, Göknur K. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutaneous Ocular Toxicol. 2014;33(2):99-102.
Kamimura M. Anti-inflammatory activity of vitamin E. J Vitaminol. 1972;18:204-9.
Djerassi D. Machlin kJ, Nocka C. Vitamin E: biochemical function and its role in cosmetics. Drug Cosmet. 1986;1:29-34.
Furuse K. Vitamin E: biological and clinical aspects of topical treatment. Cosmetics Toiletries. 1987;102:99-116.
Michaelsson G, Edqvist LE. Erythrocyte glutathione peroxidase activity in acne vulgaris and effect of selenium and vitamin E treatment. Acta Dermatol Venerol. 1984;64:9-14.
Cerio R, Dohil M, Jeanine D, Magina S, Mahe E, Stratigos AJ. Mechanism of action and clinical benefits of colloidal oatmeal for dermatologic practice. J Drugs Dermatol. 2010;9(1):1116-20.
Sooyoung K, Baochau KL, Judy HH, Kathryn AC, Stacy H, Sewon K et al. A consistent skin care regimen leads to objective and subjective improvements in dry human skin: investigator-blinded randomized clinical trial. J Dermatolog Treat. 2022;33(1):300-5.
Wahlgren CF. Itch and atopic dermatitis: clinical and experimental studies. Acta Derm Venereol Suppl (Stockh). 1991;165:1-53.
Reynertson KA, Garay M, Nebus J. Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin. J Drugs Dermatol. 2015;14:43-8.
Dick LA. Colliodal emollient baths in pediatric dermatoses. Arch Pediatr. 1958;75:506-8.
Grais ML. Role of colloidal oatmeal in dermatologic treatment of the aged. AMA Arch Derm Syphilol. 1953;68:402-7.
Smith GC. The treatment of various dermatoses associated with dry skin. J S C Med Assoc. 1958;54:282-3.