Correlation between disease activity and markers of coagulation cascade in patients of chronic spontaneous urticaria: a hospital based cross-sectional study


  • Ayesha Sharmeen Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
  • Mohammad Adil Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
  • Ravi Kumar Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India



Coagulation cascade, Extrinsic coagulation pathway, Intrinsic coagulation pathway, d-Dimer, Activated partial thromboplastin time, Prothrombin time, Urticaria activity score


Background: Both extrinsic as well as intrinsic coagulation cascade are involved in the pathogenesis of Chronic spontaneous urticaria. This study was done to correlate the disease activity and markers of coagulation cascade in patients of CSU.

Methods: A hospital-based, cross-sectional, descriptive study was carried out in 100 patients of chronic urticaria. Baseline D-Dimer, prothrombin time, activated partial thromboplastin time was performed. Disease activity was assessed using Urticaria activity score over 7 days.

Results: Of total 100 patients, d-dimer was raised in 72 (72%) patients. Correlation between D-dimer and UAS-7 days showed significant covariance between D-dimer and UAS-7 (p<0.001, r=0.93). Prothrombin time was raised in 55 (55%) patients. Significant correlation was found between PT and UAS-7 (p<0.001, r=0.76). Raised APTT was observed in 61(61%) patients. Correlation between APTT and UAS-7 showed that there was a significant covariance between APTT and UAS-7 (p<0.001, r=0.59).

Conclusions: A significant correlation between markers of coagulation cascade and the disease activity in patients of CSU was seen. These markers can help predict the disease severity and possibly monitor therapeutic response.


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