A multicentric, prospective, observational study evaluating the practice pattern and use of fixed dose topical regimen for hyperpigmentation in intimate and high friction areas
Keywords:Hyperpigmentation, Intimate areas, High-friction areas, Study, Pigmentbio sensitive areas
Background: Hyperpigmentation is the third most common dermatological disorder and has major psychosocial impairment. It comes in a variety of forms. The most well-known are age spots, freckles, melasma and post-inflammatory hyperpigmentation. Hyperpigmentation in friction-prone areas (armpits, inner thighs, elbows, knees, groin, etc.) has a significant impact on affected individuals. Unfortunately, there are currently no well-tolerated options available that are intended particularly for these sensitive areas.
Methods: Dermatologists across India were provided a questionnaire consisting of questions related to number of the patients seen with hyperpigmentation in intimate & high friction areas every week and their clinical experience regarding the use of Pigmentbio Sensitive areas containing active ingredients (Andrographolide+Glabridin+Lysine azelate+Laminaria ochroleuca extract). The results were analyzed using a visual analogue scale.
Results: The study included a total of 1402 patients, and 75 dermatologists provided complete responses. The majority (96%) of the dermatologists recommended Pigmentbio Sensitive areas for intimate & high friction areas. These dermatologists also rated tolerability and safety of Pigmentbio Sensitive areas as "excellent" to "good" based on various criteria. These included tolerability after waxing and shaving the bikini line, soothing effect after mechanical erythema from taking off tight clothing, hydrating power when compared to other products, cosmetic acceptability for frictional and intimate areas, and safety on intimate areas.
Conclusions: This study findings indicated that Pigmentbio Sensitive areas is a preferred formulation by dermatologists across India for the management of hyperpigmentation in intimate & high friction areas with proven tolerability and safety.
Iozumi K, Hoganson GE, Pennella R, Everett MA, Fuller BB. Role of tyrosinase as the determinant of pigmentation in cultured human melanocytes. J Invest Dermatol. 1993;100:806-11.
Ranu H, Thng S, Goh BK, Burger A, Goh CL. Periorbital hyperpigmentation in Asians: an epidemiologic study and a proposed classification. Dermatol Surg. 2011;37:1297-303.
Nouveau S, Agrawal D, Kohli M, Bernerd F, Misra N, Nayak CS. Skin Hyperpigmentation in Indian Population: Insights and Best Practice. Indian J Dermatol. 2016;61(5):487-95.
Hourblin V, Nouveau S, Roy N, de Lacharrière O. Skin complexion and pigmentary disorders in facial skin of 1204 women in 4 Indian cities. Indian J Dermatol Venereol Leprol. 2014;80:395-401.
Taylor SC, Cook-Bolden F, Rahman Z, Strachan D. Acne vulgaris in skin of color. J Am Acad Dermatol. 2002;46(2):S98-106.
Jablonski NG, Chaplin G. The evolution of human skin coloration. J Hum Evol. 2000;39:57-106
Arora G, Khandpur S, Bansal A, Shetty B, Aggarwal S, Saha S, et al. Current understanding of frictional dermatoses: A review. Indian J Dermatol Venereol Leprol. 2008.
Anekohji K, Maeda K, Shigemoto K, et al. A peculiar pigmentation of the skin over bony regions (Japanese). Rinsho Dermatol. 1983;25:1259-62.
Hidano A, Mizuguchi M, Higaki Y. Friction melanosis. Ann Dermatol Venereol. 1984;111:1063-71.
Sarkar R, Arora P, Garg KV. Cosmeceuticals for Hyperpigmentation: What is Available? J Cutan Aesthet Surg. 2013;6(1):4-11.
Grace R. Cosmeceuticals: Functional food for the skin. Natural Foods Merch. 2002;23:92-9.
Eves P. Anti-inflammatory and anti-invasive effects of alpha-melanocyte-stimulating hormone in human melanoma cells. Br J Cancer. 2003;89:2004-15.
Yokota T, Nishio H, Kubota Y, Mizoguchi M. The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. Pigment Cell Res. 1998;11:355‐61.
Chen J, Yu X, Huang Y. Inhibitory mechanisms of glabridin on tyros‐ inase. Spectrochim Acta Mol Biomol Spectrosc. 2016;168:111‐7.
Zhu PY, Yin WH, Wang MR, Dang YY, Ye XY. Andrographolide sup‐ presses melanin synthesis through Akt/GSK3β/β‐catenin signal pathway. J Dermatol Sci. 2015;79:74‐83.
Lgotherm A. Laminaria ochroleuca. Available at: https://algotherm.ua/en/algae/laminaria-ochroleuca. Accessed on 20 February 2023.
Arora G, Khandpur S, Bansal A, Shetty B, Aggarwal S, Saha S, et al. Current understanding of frictional dermatoses: A review. Indian J Dermatol Venereol Leprol. 2023;89(2):170-88.
Vilhena L, Ramalho A. Friction of human skin against different fabrics for medical use. Lubricants. 2016;4:6.
Safety Assessment of Brown Algae-Derived Ingredients as Used in Cosmetics. Available at: https://www.cir-safety.org/sites/default/files/Brown %20Algae_1.pdf. Accessed on 20 February 2023.
Algotherm. Laminaria ochroleuca. Available at: https://algotherm.ua/en/algae/laminaria-ochroleuca. Accessed on 20 February 2023.
Yokota T, Nishio H, Kubota Y, Mizoguchi M. The Inhibitory Effect of Glabridin from Licorice Extracts on Melanogenesis and Inflammation. Pigment Cell Res. 1998;11:355-61.
Bayazid AB, Jang YA. The Role of Andrographolide on Skin Inflammations and Modulation of Skin Barrier Functions in Human Keratinocyte. Biotechnol Bioproc. 2021;26:804-13.