A real-world data analysis on the usage of paraphenylenediamine and ammonia free hair dye


  • Manas Chatterjee Department of Dermatology, Command Hospital, Kolkata, West Bengal, India
  • Vijaya Mallela Department of Dermatology, Omni Hospital, Hyderabad, Andhra Pradesh, India
  • Gaurav Bhaskar BSD Hospital, Karnal, Haryana, India
  • Vidya T. S. Sagar Hospital, Bangalore, Karnataka, India
  • Bhagyashree Mohod Zydus Healthcare limited, Mumbai, Maharashtra, India
  • Ashok Jaiswal Zydus Healthcare limited, Mumbai, Maharashtra, India




Hair dye, PPD, Ammonia, TDS


Background: Dyeing of hair for various reasons is a common practice across a broad age group. Most hair dyes available in the market contain para-phenylenediamine (PPD) and/or ammonia, which are proven skin and scalp irritants. A quest for better tolerable hair dyes has led to emergence of toluene-2, 5-diamine sulfate (TDS) and monoethanolamine (MEA), as a substitute to PPD and ammonia, respectively.

Methods: This retrospective study was conducted on 35 participants from four centers across India to evaluate the efficacy, and tolerance of ammonia-free and PPD-free permanent hair dye.

Results: A PPD-free and ammonia-free cream-based hair dye showed promising results. The color uptake following 35 minutes of application was 100% in 54.2% of the participants. The color retention was more than 95% in 74.3% participants after 8-10 shampoo washes. The adverse effects were noted to be markedly less with only a few cases experiencing itching. The participants' feedback obtained showed a conclusively high satisfaction rate. The Physicians' assessment of efficacy and safety recorded favorable scores.

Conclusions: A TDS and MEA based cream hair color can be an effective and safe alternative to PPD and ammonia-based hair dye.


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