Growth factor concentrate therapy for management of hair loss: a prospective, real-world study
DOI:
https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20223341Keywords:
Androgenetic alopecia, Growth factor concentrate, Platelet-rich plasma technique, Global macroscopic photographs, Trichoscopic photomicrographs, Hair pull testAbstract
The present pilot study was conducted to determine the role of growth factor concentrate (GFC) therapy, a modified platelet-rich plasma (PRP) technique for the management of androgenetic alopecia. In this study, patients diagnosed with androgenic alopecia were treated with subcutaneous injections of GFC in the scalp. A total of 3 injections were administered 4 weeks apart, and the patients were followed up for 24 weeks. The treatment outcomes were assessed by taking global macroscopic photographs, trichoscopic photomicrographs, and by performing a hair pull test after 24 weeks of therapy and compared to the baseline. To determine the safety of the treatment, the incidence of any adverse event was recorded throughout the study period. The patient’s self-satisfaction was assessed using a survey-based questionnaire at the end of the study period. The global macroscopic photographs showed a significant improvement in hair growth post-GFC therapy in all 5 patients. These findings were supported by trichoscopic photomicrographs, in which a pronounced improvement in hair density along with a decrease in the shaft diameter variability and number of yellow dots were observed. Hair pull test was found to be negative in 100% of patients 4 months post-therapy. The therapy was found to be well tolerated with high patient satisfaction (80%). GFC therapy was found to have a promising role in the management of androgenetic alopecia in both male and female patients.
References
Phillips TG, Slomiany WP, Allison R. Hair Loss: Common Causes and Treatment. Am Fam Physician. 2017;96(6):371-8.
Al Aboud AM ZP. Alopecia. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing. 2022. Available at: https://wwwncbinlmnihgov/books/NBK538178/. Accessed on 12 October 2022.
Rinaldi F, Marzani B, Pinto D, Sorbellini E. Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of alopecia areata. J Dermatolog Treat. 2019;30(6):588-93.
Mysore V, Parthasaradhi A, Kharkar RD, Ghoshal AK, Ganjoo A, Ravichandran G, et al. Expert consensus on the management of Androgenetic Alopecia in India. Int J Trichol. 2019;11(3):101-6.
Qi J, Garza LA. An overview of alopecias. Cold Spring Harb Perspect Med. 2014;4(3).
Wolff H, Fischer TW, Blume-Peytavi U. The Diagnosis and Treatment of Hair and Scalp Diseases. Dtsch Arztebl Int. 2016;113(21):377-86.
Adil A, Godwin M. The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis. J Am Acad Dermatol. 2017;77(1):136-41.
Gentile P, Cole JP, Cole MA, Garcovich S, Bielli A, Scioli MG, et al. Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems. Int J Mol Sci. 2017;18(2).
Cervelli V, Garcovich S, Bielli A, Cervelli G, Curcio BC, Scioli MG, et al. The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int. 2014;760709.
Xu L, Liu KX, Senna MM. A Practical Approach to the Diagnosis and Management of Hair Loss in Children and Adolescents. Front Med (Lausanne). 2017;4:112.
Kobayashi E, Flückiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016;20(9):2353-60.
de Boer HC, van Oeveren-Rietdijk AM, Rotmans JI, Dekkers OM, Rabelink TJ, van Zonneveld AJ. Activated platelets correlate with mobilization of naïve CD34(+) cells and generation of CD34(+) /KDR(+) cells in the circulation. A meta-regression analysis. J Thromb Haemost. 2013;11(8):1583-92.
Takakura N, Yoshida H, Kunisada T, Nishikawa S, Nishikawa SI. Involvement of platelet-derived growth factor receptor-alpha in hair canal formation. J Invest Dermatol. 1996;107(5):770-7.
Hou C, Miao Y, Wang J, Wang X, Chen CY, Hu ZQ. Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression. Drug Des Devel Ther. 2015;9:5373-83.
Zhang H, Nan W, Wang S, Zhang T, Si H, Yang F, et al. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling. Cellular Physiology and Biochemistry. 2016;39(1):360-70.
Trüeb RM. Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia. Skin Appendage Disorders. 2018;4(2):90-5.
Tan P-C, Xie Y, Wu W, Zhang P, Gao Y, Liu K, et al. Concentrated Growth Factor from Autologous Platelet Promotes Hair Growth in Androgenetic Alopecia. J Biomed Sci Eng. 2019;12(03):201-11.
Bhoite KS CS, Mishra SN, Kharkar VD. Injectable platelet rich fibrin therapy for androgenetic alopecia: a series of 15 cases. Int J Res Dermatol. 2022;8:398-402.
Steward EN, Patel H, Pandya H, Dewan H, Bhavsar B, Shah U, et al. Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia - A Retrospective Study. Ann Maxillofac Surg. 2020;10(2):409-16.
Khatu SS, More YE, Gokhale NR, Chavhan DC, Bendsure N. Platelet-rich plasma in androgenic alopecia: myth or an effective tool. J Cutan Aesthet Surg. 2014;7(2):107-10.