Comparative real world clinical assessment of fixed dose combination of mometasone and fusidic acid cream versus fluticasone and mupirocin ointment in the management of atopic dermatitis with secondary bacterial infection


  • Indur Ramchandani KEMPS corner, Mumbai, Maharashtra, India
  • Namrata Mahadkar Global Medical Affairs, Glenmark Pharmaceuticals Ltd. Mumbai, Maharashtra, India
  • Dhiraj S. Dhoot Global Medical Affairs, Glenmark Pharmaceuticals Ltd. Mumbai, Maharashtra, India
  • Hanmant Barkate Global Medical Affairs, Glenmark Pharmaceuticals Ltd. Mumbai, Maharashtra, India



Mometasone, Fluticasone, FDC, Secondary bacterial infections


Background: Bacterial skin infections caused by gram positive bacteria are mostly encountered in paediatric age group. These infections are found to commonly complicate atopic dermatitis with prevalence of 80-100%, and are treated with fixed dose combination (FDC) of topical corticosteroids and antibiotics.

Methods: This retrospective study was conducted in patients ≥2 years of age with a diagnosis of atopic dermatitis with secondary bacterial infections and having investigator’s global assessment score of 2 or 3. Patient’s clinical outcomes were analysed on the basis of skin infection rating scale (SIRS) wherein each of signs/symptom were rated on scale of 0 to 3.

Results: The 206 patients had received FDC of mometasone and fusidic acid (MF) and 159 patients had received fluticasone and mupirocin (FM). Percentage of patients achieving complete clearance of symptoms/signs was higher in MF group as compared to FM. Percentage of patients achieving clinical success were significantly higher with mometasone. Recurrences and percentage of patients with clinical failure were higher in FP group. 

Conclusions: Effectiveness of MF FDC was significant as compared to FM, FDC in terms of complete clearance of lesions, increased number of patients achieving clinical success and less number of recurrences.



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