Management of skin and soft-tissue infections and acne with topical nadifloxacin: a comprehensive review

Authors

  • Snehal Muchhala Medical GG India, Dr. Reddy’s Laboratories Limited, Hyderabad, Telangana, India http://orcid.org/0000-0002-5827-2012
  • Rashmi Sarkar Department of Dermatology, Lady Hardinge Medical College and Associated SSK Hospital and KSC Hospital, New Delhi, India
  • Koushik Lahiri Department of Dermatology, Apollo Gleneagles Hospitals, Kolkata, West Bengal, India
  • Rajendra D. Kharkar Department of Dermatology and Cosmetology, Dr Kharkar Clinic, Suchak Hospital, Malad, Mumbai, Maharashtra, India
  • Rahul Rathod Ideation and Clinical Research GG India, Dr. Reddy’s Laboratories Limited, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20222726

Keywords:

Acne vulgaris, SSTI, Nadifloxacin, Antibiotic resistance, Biofilm, Topical

Abstract

Skin and soft tissue infections (SSTIs) and acne are multi-factorial skin conditions that involve microbial invasion of the skin and underlying soft tissues; though, both have different pathogenesis. Most of these infections are caused by bacteria, affecting all age groups. Early diagnosis and appropriate antimicrobial therapy remain the cornerstone of management of SSTIs and acne. Over the years, an increase in antibiotic resistance has been reported with mupirocin and fusidic acid that makes the management of SSTIs and acne increasingly challenging. Further, these antibiotics are unable to penetrate biofilms and show their action on the microorganisms embedded deep in the polymeric matrix. In this review, we have discussed the current evidence on the efficacy and safety profile of nadifloxacin compared to other currently available antimicrobial agents. An extensive search was performed through PubMed and Medline using relevant key words. This article has highlighted nadifloxacin’s broad antimicrobial spectrum, unique dual mechanism of action, distinct characteristics like ability to retain efficacy in acidic pH, low antibiotic resistance and superior action against biofilms. This review concludes that nadifloxacin, could be a potential empirical therapy in the management of SSTIs and acne.

Author Biographies

Snehal Muchhala, Medical GG India, Dr. Reddy’s Laboratories Limited, Hyderabad, Telangana, India

Team Lead – Medical

Rashmi Sarkar, Department of Dermatology, Lady Hardinge Medical College and Associated SSK Hospital and KSC Hospital, New Delhi, India

Director Professor, Department of Dermatology

Koushik Lahiri, Department of Dermatology, Apollo Gleneagles Hospitals, Kolkata, West Bengal, India

Professor and Senior Consultant Dermatologist

 

Rajendra D. Kharkar, Department of Dermatology and Cosmetology, Dr Kharkar Clinic, Suchak Hospital, Malad, Mumbai, Maharashtra, India

Senior Consultant Dermatologist and cosmetologist

Rahul Rathod, Ideation and Clinical Research GG India, Dr. Reddy’s Laboratories Limited, Hyderabad, Telangana, India

Head – Ideation & Clinical Research

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Published

2022-10-27

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Section

Systematic Reviews