Skin: mirror of marrow- case of POEMS syndrome
Keywords:POEMS syndrome, Hypergammaglobulinopathies, Skin disorder
Monoclonal gammopathy is clonal proliferation and accumulation of immunoglobulin producing B-cells. A variety of skin disorders are associated with an increased level of monoclonal immunoglobulin proteins. Synonyms such as monoclonal gammopathies, paraproteinemias, plasma cell dyscrasias and dysproteinemias are used to designate gammaglobinopathies. Here in we report a case of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome presenting with sclerodermoid features.
Dispenzieri A, Kyle RA, Lacy MQ, Rajkumar SV, Therneau TM, Larson DR, et al. POEMS syndrome: Definitions and long-term outcome. Blood. 2003;101(7):2496–506.
Bardwick PA, Zvaifler NJ, Gill GN, Newman D, Greenway GD, Resnick DL. Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature. Med. 1980;59(4):311–22.
Driedger H, Pruzanski W. Plasma Cell Neoplasia With Osteosclerotic Lesions. Arch Intern Med. 1979;139(8):892.
Nakanishi T, Sobue I, Toyokura Y, Nishitani H, Kuroiwa Y, Satoyoshi E, et al. The Crow-Fukase syndrome: a study of 102 cases in Japan. Neurol. 1984;34(6):712–20.
Plasma Cell Neoplasia with Peripheral Polyneuropathy: A STUD. Medicine. Available at: http://journals.lww.com/md-journal/Citation/1980/ 07000/Plasma_Cell_Neoplasia_with_Peripheral.5.aspx. Assessed on 23 March 2017.