Localized pustular psoriasis in a child treated successfully with topical dapsone gel
DOI:
https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20214784Keywords:
Localized pustular psoriasis, Palmoplantar pustular psoriasis, Acrodermatitis continua of Halloppeau, dapsone, G6PD, ChildrenAbstract
Psoriasis is a chronic inflammatory, immune mediated dermatosis in children and adults. About one third of cases affected with psoriasis have their onset in first and second decade of life. Of paediatric population, about 0.5-2% is affected, infants are rarely affected. Overall plaque psoriasis is most common type followed by guttate and pustular psoriasis. Treating severe forms of psoriasis such as pustular psoriasis and erythrodermic psoriasis can pose difficulties, especially in paediatric population. Hence paediatric psoriasis needs to be managed effectively, however effective therapy also poses the risk of producing adverse effects, more so in paediatric age group. We report a case of localized pustular psoriasis, with an antineutrophil agent which is much safer and may target directly the pathophysiology of pustular psoriasis.
Metrics
References
Augustin M, Glaeske G, Radtke MA, Christophers E, Reich K, Schafer I. Epidemiology and comorbidity of psoriasis in children. Br J Dermat. 2010;162(3):633-6.
2.Patrizi A, Neri I, Ricci G, Cipriani F, Ravaioli GM. Advances in pharmacotherapeutic management of common skin diseases in neonates and infants. Expert Opin Pharmacother. 2017;18:717 25.
Mahé E. Childhood psoriasis. Eur J Dermatol. 2016;26:537 48.
Kravvas G, Gholam K. Use of topical therapies for pediatric psoriasis: A systematic review. Pediatr Dermatol. 2018;35:296 302.
Dogra S, Kaur I. Childhood psoriasis. Indian J Dermatol Venereol Leprol. 2010;76:357 65.
Cassandra M, Conte E, Cortez B. Childhood pustular psoriasis elicited by the streptococcal antigen: a case report and review of the literature. Pediatr Dermatol. 2003;20:506-10.
Kopp T, Karlhofer F, Sze´pfalusi Z. Succesful use of acitretin in conjunction with narrowband ultraviolet B phototherapy in a child with severe pustular psoriasis, von Zumbusch type. Br J Dermatol. 2004;151:912-6.
Augey F, Renaudier P, Nicolas JF. Generalized pustular psoriasis (Zumbusch): a French epidemiological survey. Eur J Dermatol. 2006;16:669-73.
Dogra S, Kaur I. Childhood psoriasis. Indian J Dermatol Venereol Leprol. 2010;76:357 65.
Kim HS, Kim GM, Kim SY. Two-stage therapy for childhood generalized pustular psoriasis: low-dose cyclosporine for induction and maintenance with acitretin ⁄ narrowband ultraviolet B phototherapy. Pediatr Dermatol. 2006;23:306-8.
. Marcoux D, Prost Y. Pediatric psoriasis revisited. J Cutan Med Surg. 2002;6:22-8.
Macmillan AL, Champion RH: Generalized pustular psoriasis treated with dapsone. Br J Dermatol. 1973;88:183-5.
Wozel G. Dapsone hydroxylamine inhibits the LTB4-induced chemotaxis of polymorphonuclear leukocytes into human skin: results of a pilot study. Inflamm Res. 1997;46:420-2.
Pfeiffer C, Wozel G. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol. 2003;48:308-9.
Zhu KJ. Complete atrioventricular block associated with dapsone therapy: a rare complication of dapsone-induced hypersensitivity syndrome. J Clin Pharm Ther. 2009;34:489-92.
Lorenz M, Wozel G, Schmitt J. Hypersensitivity reactions to dapsone: a systematic review. Acta Derm Venereol. 2012;92:194-9.
Dapsone: Administration/Monitoring. Micromedex 2.0. Truven Health Analytics, I.G.V., CO. Available at: http://www.micromedexsolutions.com. Accessed on 30 September 2014.
Stotland M, Shalita AR, Kissling RF. Dapsone 5% gel: a review of its efficacy and safety in the treatment of acne vulgaris. Am J Clin Dermatol. 2009;10:221-7.