An approach to treatment modalities of keloids: a comparative study

Authors

  • Sweta S. Parmar Department of Dermatology, GMERS Medical College, Vadnagar, Gujarat, India
  • Avani Modi Department of Dermatology, GMERS Medical College, Vadnagar, Gujarat, India

DOI:

https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20214911

Keywords:

Keloid, Intralesional injection, Treatment, Triamcinolone acetonide

Abstract

Background: In spite of the presence of such an array of treatment modalities, none of these can be claimed to be an ideal treatment option as most of them have limited efficacy, significant side effects or increased chances of recurrence. Hence the study was undertaken to search an ideal treatment for keloids which is safe, effective, and with low rate of recurrence.

Methods: Total of 200 patients were recruited out of which only 160 patients were included in study. The patients were divided into three groups and administered with different modes of treatment. Patients in all the groups were followed up at 3 weekly intervals for evaluation of response. At the end of the study, the data was compiled and analysed using appropriate statistical tests.

Results: In only 32 patients completed study in group 1, 2 and 3 respectively. Group 1, 2 and 3 were more or less equally efficacious with clearance rate. Complete clearance was seen in 24 patients in group 1 patients, in group 2 there were 22 patients with complete clearance and in group 3 there were 24 patients.

Conclusions: Intralesional triamcinolone acetonide, intralesional triamcinolone acetonide with hyaluronidase and intralesional radiofrequency with intralesional triamcinolone acetonide are almost equally effective modalities for the treatment of keloids. But, intralesional triamcinolone acetonide with hyaluronidase fares better than other two as far as safety is concerned with least side effects.

 

References

Muir I. On the nature of keloid and hypertrophic scars. Br J Plastic Surg. 1990;43:61-9.

Juckett G, Hartman-Adams H. Management of keloids and hypertrophic scars. Am Fam Physician. 2009;80:253-60.

Betarbet U, Blalock TW. Keloids: A review of etiology, prevention, and treatment. J Clin Aesthetic Dermatol. 2020;13:33.

Srinivasan G. Clinico-pathological study of Cutaneous Tumours of Head and Neck. Chengalpattu Medical College, Chengalpattu. 2011.

Berman B, Maderal A, Raphael B. Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg. 2017;43:3-18.

Darzi MA, Chowdri NA, Kaul SK, Khan M. Evaluation of various methods of treating keloids and hypertrophic scars: a 10-year follow-up study. Br J Plastic Surg. 1992;45:374-9.

Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med. 2011;17:113-25.

El Mcherqui I. Management of keloids and hypertrophic scars. University of Zagreb. School of Medicine. 2019.

Onyenyirionwu E, Agu A. Keloids: A review. J Med Investig Practice. 2015;10:24.

Koc E, Arca E, Surucu B, Kurumlu Z. An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids. Dermatol Surg. 2008;34:1507-14.

Ahuja RB, Chatterjee P. Comparative efficacy of intralesional verapamil hydrochloride and triamcinolone acetonide in hypertrophic scars and keloids. Burns. 2014;40:583-8.

Goyal NN, Gold MH: A novel triple medicine combination injection for the resolution of keloids and hypertrophic scars. J Clin Aesth Dermatol. 2014;7:31.

Fruth K, Gouveris H, Kuelkens C, Mann WJ. Radiofrequency tissue volume reduction for treatment of auricle keloids. The Laryngoscope. 2011;121:1233-6.

Klockars T, Bäck L, Sinkkonen S. Radiofrequency ablation for treatment of auricular keloids: our experience in eleven patients. Clin Otolaryngol. 2013;38:381-5.

Weshay AH, Hay RMA, Sayed K, El Hawary MS, Nour-Edin F: Combination of radiofrequency and intralesional steroids in the treatment of keloids: a pilot study. Dermatol Surg. 2015;41:731-5.

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Published

2021-12-24

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Original Research Articles